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Rs1801133
C677T or rs1801133 is a genetic variation—a single nucleotide polymorphism (SNP)—in the ''MTHFR'' gene. Among Americans the frequency of T-homozygosity ranges from 1% or less among people of sub-Saharan African descent to 20% or more among Italians and Hispanics. It has been related to * schizophrenia * Alzheimer's disease * depression * autism * spina bifida. In 2000 association studies on oral clefts, Down syndrome, and fetal anticonvulsant syndrome were either unreplicated or had yielded conflicting results. Related genetic variants A1298C A1, A-1, A01 or A.1. may refer to: Education * A1, the Basic Language Certificate of the Common European Framework of Reference for Languages * Language A1, the former name for "Language A: literature", one of the IB Group 1 subjects * A1, a ... is a SNP in the same gene. Studies have investigated the combined effect of C677T and A1298C. References {{Reflist SNPs on chromosome 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MTHFR
Methylenetetrahydrofolatereductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the ''MTHFR'' gene. Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Natural variation in this gene is common in otherwise healthy people. Although some variants have been reported to influence susceptibility to occlusive vascular disease, neural tube defects, Alzheimer's disease and other forms of dementia, colon cancer, and acute leukemia, findings from small early studies have not been reproduced. Some mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. Complex I deficiency with recessive spastic paraparesis has also been linked to ''MTHFR'' variants. In addition, the aberrant promoter hypermethylation of this gene is associated with male infertility and recurrent spontaneous abortion. Bio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single Nucleotide Polymorphism
In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, at a specific base position in the human genome, the G nucleotide may appear in most individuals, but in a minority of individuals, the position is occupied by an A. This means that there is a SNP at this specific position, and the two possible nucleotide variations – G or A – are said to be the alleles for this specific position. SNPs pinpoint differences in our susceptibility to a wide range of diseases, for example age-related macular degeneration (a common SNP in the CFH gene is associated with increased risk of the disease) or nonalcoholic fatty liver disease (a SNP in the PNPLA3 gene is associated with incr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Y
Michael may refer to: People * Michael (given name), a given name * Michael (surname), including a list of people with the surname Michael Given name "Michael" * Michael (archangel), ''first'' of God's archangels in the Jewish, Christian and Islamic religions * Michael (bishop elect), English 13th-century Bishop of Hereford elect * Michael (Khoroshy) (1885–1977), cleric of the Ukrainian Orthodox Church of Canada * Michael Donnellan (1915–1985), Irish-born London fashion designer, often referred to simply as "Michael" * Michael (footballer, born 1982), Brazilian footballer * Michael (footballer, born 1983), Brazilian footballer * Michael (footballer, born 1993), Brazilian footballer * Michael (footballer, born February 1996), Brazilian footballer * Michael (footballer, born March 1996), Brazilian footballer * Michael (footballer, born 1999), Brazilian footballer Rulers =Byzantine emperors= *Michael I Rangabe (d. 844), married the daughter of Emperor Nikephoros ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feng Yang
Feng may refer to: *Feng (surname), one of several Chinese surnames in Mandarin: **Féng (surname) ( wikt:冯 féng 2nd tone "gallop"), very common Chinese surname **Fèng (surname) ( wikt:鳳 fèng 4th tone "phoenix"), relatively common Chinese family name **Fēng (surname) ( wikt:風 fēng 1st tone "wind"), rare Chinese surname **Fèng ( wikt:奉 fèng 4th tone "offer"), rare Chinese surname *Feng (chieftain), legendary Jutish chieftain and the prototype for William Shakespeare's King Claudius *FEng, Fellow of Royal Academy of Engineering *Fengjing, the former capital of the duchy of Zhou during the late Shang dynasty *Feng County, Shaanxi, in China *Feng County, Jiangsu, in China *Fenghuang, mythological birds of East Asia *Feng (mythology), Chinese legendary creature that resembles a lump of meat and regenerates after being eaten *Cardinal Feng, in Monty Python's Spanish Inquisition * Feng Office (web application), open source team collaboration software * Feng (program), openso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ömer Aras
Omar/Umar ( ar, عمر) is a masculine given name that has different origins in three languages across the world (Arabic, Hebrew and Germanic) even though it is best known as an Arabic name and the name Omar was mentioned in the Old Testament. Omar is represented in Islamic traditions. The name means "flourishing, long lived". After the emergence and military success of Islam, which was partly due to the second caliph Umar ibn al-Khattab (also spelled Omar, ), Umar or Omar became a common name in Muslim Arab and Muslim populations in general. The name is also used in Spanish-speaking countries. There was a biblical figure by the name of Omar. In the Middle Ages, there was a large population of Jews and Muslims in Spain, therefore the name could have spread because of this. The name Omar (spelled as Ómar) is also popular as a man's name in Iceland, and to a much lesser extent in Nordic countries. The name can also be a variant of Ottomar or Othmar, a Germanic name consi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naomi Q
Naomi or Naomie may refer to: People and biblical figures * Naomi (given name), a female given name and a list of people with the name * Naomi (biblical figure), Ruth's mother-in-law in the Old Testament Book of Ruth * Naomi (Romanian singer) (born 1977), a.k.a. Naomy * Naomi (wrestler) (born 1987), professional wrestler * Terra Naomi, American indie folk singer-songwriter Arts and entertainment Fictional entities * Naomi, a character in the 2009 American fantasy comedy movie '' 17 Again'' * Naomi Bohannon, a character in the TV series ''Hell on Wheels'' * Naomi, Florida, a fictional town in the Kate DiCamillo novel ''Because of Winn-Dixie'' * Naomi Turner, a character in the American animated television series ''Elena of Avalor'' Music * Naomi Awards, a former British music award * ''Naomi'' (album), by American band The Cave Singers * "Naomi" (song), by Neutral Milk Hotel Other uses in arts and entertainment * ''Naomi'' (novel), a 1924 novel by Jun'ichirō Tanizaki * ''Na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A1298C
A1, A-1, A01 or A.1. may refer to: Education * A1, the Basic Language Certificate of the Common European Framework of Reference for Languages * Language A1, the former name for "Language A: literature", one of the IB Group 1 subjects * A1, a secondary school subdivision in the Congolese education system * A1, a baccalauréat series in the education system of some parts of France * A1, a baccalaureate in the Gabonese education system, see Education in Gabon * A1, the highest category of Qualified Flying Instructor in the Central Flying School of the UK Royal Air Force Grades * A1, a grade for the Leaving Certificate, a qualification in the education system of Ireland * A1, the highest obtainable grade for the Sijil Pelajaran Malaysia examination in Malaysia * A1, a grade for the Senior Secondary Certificate Examination in Nigeria, see Education in Nigeria * A1, a grade for the Singaporean GCE 'O' Level, an examination in the education system of Singapore * A-1, an Academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fetal Anticonvulsant Syndrome
A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal development begins from the ninth week after fertilization (or eleventh week gestational age) and continues until birth. Prenatal development is a continuum, with no clear defining feature distinguishing an embryo from a fetus. However, a fetus is characterized by the presence of all the major body organs, though they will not yet be fully developed and functional and some not yet situated in their final anatomical location. Etymology The word ''fetus'' (plural ''fetuses'' or '' feti'') is related to the Latin '' fētus'' ("offspring", "bringing forth", "hatching of young") and the Greek "φυτώ" to plant. The word "fetus" was used by Ovid in Metamorphoses, book 1, line 104. The predominant British, Irish, and Commonwealth spelling is ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Down Syndrome
Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an eight- or nine-year-old child, but this can vary widely. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45. The extra chromosome is believed to occur by chance, with no known behavioral activity or environmental factor that changes the probability. Down syndrome can be identified during pregnancy by prenatal screening followed by diagnostic testing or after birth by direct observation and genetic testing. Since the introduction of screening, Down syndrome pregnancies are often abor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral Cleft
The word oral may refer to: Relating to the mouth * Relating to the mouth, the first portion of the alimentary canal that primarily receives food and liquid **Oral administration of medicines ** Oral examination (also known as an oral exam or oral test), a practice in many schools and disciplines in which an examiner poses questions to the student in spoken form ** Oral hygiene, practices involved in cleaning the mouth and preventing disease **Oral medication **Oral rehydration therapy, a simple treatment for dehydration associated with diarrhea **Oral sex, sexual activity involving the stimulation of genitalia by use of the mouth, tongue, teeth or throat. **Oral stage, a human development phase in Freudian developmental psychology **Oral tradition, cultural material and tradition transmitted orally from one generation to another **Oralism, the education of deaf students through oral language by using lip reading, and mimicking of mouth shapes and breathing patterns **Speech communi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidemiology (journal)
''Epidemiology'' is a bi-monthly, peer-reviewed journal for epidemiologic research, published by Lippincott Williams & Wilkins. The journal publishes original research from all fields of epidemiology, as well as review articles, meta-analyses, novel hypotheses, descriptions and applications of new methods and discussions of research theory and public health policy. It is the official journal of the International Society for Environmental Epidemiology (ISEE). In 2020, Epidemiology had an impact factor of 4.822, ranking 35th among 203 journals in the field of public, environmental and occupational health. Epidemiology was founded by Ken Rothman in 1990. Allen Wilcox Allen James Wilcox is an American epidemiologist who heads the reproductive epidemiology group at the National Institute of Environmental Health Sciences (NIEHS). Education Wilcox received his BA degree from the University of Michigan in 1968 and ... has been Editor-in-Chief since 2001. Its editorial offices are i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spina Bifida
Spina bifida (Latin for 'split spine'; SB) is a birth defect in which there is incomplete closing of the spine and the membranes around the spinal cord during early development in pregnancy. There are three main types: spina bifida occulta, meningocele and myelomeningocele. Meningocele and myelomeningocele may be grouped as spina bifida cystica. The most common location is the lower back, but in rare cases it may be in the middle back or neck. Occulta has no or only mild signs, which may include a hairy patch, dimple, dark spot or swelling on the back at the site of the gap in the spine. Meningocele typically causes mild problems, with a sac of fluid present at the gap in the spine. Myelomeningocele, also known as open spina bifida, is the most severe form. Problems associated with this form include poor ability to walk, impaired bladder or bowel control, accumulation of fluid in the brain (hydrocephalus), a tethered spinal cord and latex allergy. Learning problems are rela ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
