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Prontosil
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist. The discovery and development of this first sulfonamide-containing drug opened a new era in medicine, because it greatly widened the success of antimicrobial chemotherapy in an era when many physicians doubted its still largely untapped potential. At the time, disinfectant cleaners and topical antiseptic wound care were widely used but there were very few antimicrobial drugs to use safely inside living bodies. Antibiotic drugs derived from microbes, which are relied on heavily today, did not yet exist. Prontosil was discovered in 1932 by a research team at the Bayer Laboratories of the IG Farben conglomerate in Germany led by Gerhard Domagk. Domagk received the 1939 Nobel Prize in Physiol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Domagk
Gerhard Johannes Paul Domagk (; 30 October 1895 – 24 April 1964) was a German pathologist and bacteriologist. He is credited with the discovery of Sulfonamide (medicine), sulfonamidochrysoidine (KL730) as an antibiotic for which he received the 1939 Nobel Prize in Physiology or Medicine. The drug became the first commercially available antibiotic and marketed under the brand name Prontosil. While working in the pathology department of the University of Münster, Domagk was invited to join the IG Farben branch at Elberfeld (later Wuppertal) in 1927. His duty was to test chemical compounds prepared at the IG Farben laboratory for potential drugs. A novel compound synthesised by Friedrich Mietzsch and Joseph Klarer, a benzene derivative of azo dye attached with sulphonamide group as a side chain was found to have antibacterial activity against human bacterium ''Streptococcus pyogenes.'' In 1935, Domagk's only daughter, Hildegarde, injured herself and contracted a streptococcal in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, treatment and antibiotic prophylaxis, prevention of such infections. They may either bactericide, kill or bacteriostatic agent, inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek language, Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamide (medicine)
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of medication, drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the Sulfonamide (chemistry), sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Drug allergy, Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibacterial
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard Colebrook
Leonard Colebrook FRS ( – ) was an English physician and bacteriologist. Education Colebrook was educated at the Grammar School in Guildford (1891–96), Westbourne High School in Bournemouth (1896–99) and Christ's College Blackheath in Kent (1899 - 1900). Colebrook started his medical training at the London Hospital Medical College after which he won a scholarship to St Mary's Hospital, London, graduating in 1906 with M.B. and B.S. (Lond). degrees. Career He stayed at St Mary's Hospital Medical School from 1907 - 14. he was initially appointed as an assistant to Sir Almroth Wright in the inoculation Department. He worked on vaccine therapy, tuberculosis and pneumonia. At the outbreak of the First World War he was appointed as a captain in the Royal Army Medical Corps and the Battalion Medical Officer of the Kensington Regiment. He stayed initially at St Mary's Hospital but in 1917 was transferred to France where he worked on wound infections with Sir Almroth Wright at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayer
Bayer AG (English: , commonly pronounced ; ) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world. Headquartered in Leverkusen, Bayer's areas of business include: pharmaceuticals, consumer healthcare products, agricultural chemicals, seeds and biotechnology products. The company is a component of the EURO STOXX 50 stock market index. Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer (1825–1880) and dyer Friedrich Weskott (1821–1876). The company was established as a dyestuffs producer, but the versatility of aniline chemistry led Bayer to expand its business into other areas. In 1899, Bayer launched the compound acetylsalicylic acid under the trademarked name Aspirin. Aspirin is on the World Health Organization's List of Essential Medicines. In 2021, it was the 34th most commonly prescribed medication in the United State ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral
The word oral may refer to: Relating to the mouth * Relating to the mouth, the first portion of the alimentary canal that primarily receives food and liquid **Oral administration of medicines ** Oral examination (also known as an oral exam or oral test), a practice in many schools and disciplines in which an examiner poses questions to the student in spoken form ** Oral hygiene, practices involved in cleaning the mouth and preventing disease ** Oral medication ** Oral rehydration therapy, a simple treatment for dehydration associated with diarrhea **Oral sex, sexual activity involving the stimulation of genitalia by use of the mouth, tongue, teeth or throat. ** Oral stage, a human development phase in Freudian developmental psychology **Oral tradition, cultural material and tradition transmitted orally from one generation to another **Oralism, the education of deaf students through oral language by using lip reading, and mimicking of mouth shapes and breathing patterns **Speech com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptococcus Pyogenes
''Streptococcus pyogenes'' is a species of Gram-positive, aerotolerant bacteria in the genus '' Streptococcus''. These bacteria are extracellular, and made up of non-motile and non-sporing cocci (round cells) that tend to link in chains. They are clinically important for humans, as they are an infrequent, but usually pathogenic, part of the skin microbiota that can cause group A streptococcal infection. ''S. pyogenes'' is the predominant species harboring the Lancefield group A antigen, and is often called group A ''Streptococcus'' (GAS). However, both '' Streptococcus dysgalactiae'' and the '' Streptococcus anginosus'' group can possess group A antigen as well. Group A streptococci, when grown on blood agar, typically produce small (2–3 mm) zones of beta-hemolysis, a complete destruction of red blood cells. The name group A (beta-hemolytic) ''Streptococcus'' is thus also used. The species name is derived from Greek words meaning 'a chain' () of berries ( atiniz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Gelmo
Paul Josef Jakob Gelmo (17 December 1879 – 22 October 1961) was an Austrian chemist who worked on synthetic dyes and discovered sulfanilamide in 1908, although their antibiotic properties were discovered only in 1932. Gelmo was born in Vienna and went to the Technische Hochschule where he received a diploma in 1903 and a doctorate in 1906. He then worked with Wilhelm Suida. During this period he examined azo dyes and synthesized several compounds, including sulfanilamide for applications in dyeing. From 1910 he worked as chief chemist for the Austrian Printing Office, and in 1929 he became a lecturer in chemistry at the Technische Hochschule. In 1932 Gerhard Domagk found that the dye prontosil inhibited streptococci and the active metabolite An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical. Active metabolites may produce therapeutic effects, as well as harmful e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wuppertal
Wuppertal (; ) is a city in North Rhine-Westphalia, in western Germany, with a population of 355,000. Wuppertal is the seventh-largest city in North Rhine-Westphalia and List of cities in Germany by population, 17th-largest in Germany. It was founded in 1929 by the merger of Elberfeld, Barmen, Ronsdorf, Cronenberg, Wuppertal, Cronenberg and Vohwinkel Schwebebahn, Vohwinkel, and was initially called "Barmen-Elberfeld" before adopting its present name in 1930. It is the capital and largest city of the Bergisches Land. The city straddles the densely populated banks of the River Wupper, a tributary of the Rhine. Wuppertal is located between the Ruhr (Essen) to the north, Düsseldorf to the west, and Cologne to the southwest, and over time has grown together with Solingen, Remscheid and Hagen. The stretching of the city in a long band along the narrow Wupper Valley leads to a spatial impression of Wuppertal being larger than it actually is. The city is known for its steep slope ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Vienna
The University of Vienna (, ) is a public university, public research university in Vienna, Austria. Founded by Rudolf IV, Duke of Austria, Duke Rudolph IV in 1365, it is the oldest university in the German-speaking world and among the largest institutions of higher learning in Europe. The university is associated with 17 List of Nobel laureates, Nobel Prize winners and has been the home to many scholars of historical and academic importance. History Middle Ages to the Enlightenment The university was founded on March 12, 1365, by Rudolf IV, Duke of Austria, hence the name "Alma Mater Rudolphina". After the Charles University in Prague (1347) and Jagiellonian University in Kraków (1364), the University of Vienna is the third oldest university in Central Europe and the oldest university in the contemporary German-speaking world; it remains a question of definition as the Charles University in Prague was German-speaking when founded, too. However, Pope Urban V did not ratify th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azo Dye
Azo dyes are organic compounds bearing the functional group R−N=N−R′, in which R and R′ are usually aryl and substituted aryl groups. They are a commercially important family of azo compounds, i.e. compounds containing the C−N=N−C linkage. Azo dyes are synthetic dyes and do not occur naturally. Most azo dyes contain only one azo group but there are some that contain two or three azo groups, called "diazo dyes" and "triazo dyes" respectively. Azo dyes comprise 60–70% of all dyes used in food and textile industries. Azo dyes are widely used to treat textiles, leather articles, and some foods. Chemically related derivatives of azo dyes include azo pigments, which are insoluble in water and other solvents. Classes Many kinds of azo dyes are known, and several classification systems exist. Some classes include disperse dyes, metal-complex dyes, reactive dyes, and substantive dyes. Also called direct dyes, substantive dyes are employed for cellulose-based textil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
