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Polyphyodont
A polyphyodont is any animal whose tooth (animal), teeth are continually replaced. In contrast, diphyodonts are characterized by having only two successive sets of teeth. Polyphyodonts include most toothed fishes (most notably sharks), many reptiles such as crocodiles and geckos, and most other vertebrates, with mammals being the main exception (though Polyphyodont#Evolution in mammals, not absolute). Growth New, permanent teeth grow in the jaws, usually under or just behind the old tooth, from stem cells in the dental lamina. Young animals typically have a full set of teeth when they hatch; there is no tooth change in the egg. Within days, tooth replacement begins, usually in the back of the jaw continuing forward like a wave. On average a tooth is replaced every few months. Crocodilia Crocodilia are the only non-mammalian vertebrates with tooth sockets. Alligators grow a successional tooth (a small replacement tooth) under each mature functional tooth for replacement once a y ...
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Regeneration (biology)
Regeneration in biology is the process of renewal, restoration, and tissue growth that makes genomes, cell (biology), cells, organisms, and ecosystems Resilience (ecology), resilient to natural fluctuations or events that cause disturbance or damage. Every species is capable of regeneration, from bacteria to humans. Regeneration can either be complete where the new tissue is the same as the lost tissue, or incomplete after which the necrotic tissue becomes Fibrosis, fibrotic. At its most elementary level, regeneration is mediated by the molecular processes of gene regulation and involves the cellular processes of cell proliferation, morphogenesis and cell differentiation. Regeneration in biology, however, mainly refers to the Morphogenesis, morphogenic processes that characterize the phenotypic plasticity of Phenotypic trait, traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. Above the genetic level, rege ...
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Tooth (animal)
A tooth (: teeth) is a hard, calcified structure found in the jaws (or mouths) of many vertebrates and used to break down food. Some animals, particularly carnivores and omnivores, also use teeth to help with capturing or wounding prey, tearing food, for defensive purposes, to intimidate other animals often including their own, or to carry prey or their young. The roots of teeth are covered by gums. Teeth are not made of bone, but rather of multiple tissues of varying density and hardness that originate from the outermost embryonic germ layer, the ectoderm. The general structure of teeth is similar across the vertebrates, although there is considerable variation in their form and position. The teeth of mammals have deep roots, and this pattern is also found in some fish, and in crocodilians. In most teleost fish, however, the teeth are attached to the outer surface of the bone, while in lizards they are attached to the inner surface of the jaw by one side. In cartilaginous f ...
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Tooth Regeneration
Tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell, stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells. As a source of the new bioengineered teeth, somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolymer in the shape of the new tooth. History Young et al first demonstrated in 2002 that teeth could be regenerated from cells. The first clinical trial on tooth regeneration started in 2023 in Japan, for a medicine stimulating tooth regrowth by inhibition of USAG-1. In April 2025, researchers in the UK successfully grew human teeth in a lab, offering a potential alternative to dental implants and fillings. Challenges The majority of stem cell studies have stopped at the stage of animal studies and have not proceeded to clinical trials due to numerous saf ...
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Tooth Socket
Dental alveoli (singular ''alveolus'') are sockets in the jaws in which the roots of teeth are held in the alveolar process with the periodontal ligament. The lay term for dental alveoli is tooth sockets. A joint that connects the roots of the teeth and the alveolus is called a ''gomphosis'' (plural ''gomphoses''). Alveolar bone is the bone that surrounds the roots of the teeth forming bone sockets. In mammals, tooth sockets are found in the maxilla, the premaxilla, and the mandible. Etymology 1706, "a hollow", especially "the socket of a tooth", from Latin alveolus "a tray, trough, basin; bed of a small river; small hollow or cavity", diminutive of alvus "belly, stomach, paunch, bowels; hold of a ship", from PIE root *aulo- "hole, cavity" (source also of Greek aulos "flute, tube, pipe"; Serbo-Croatian, Polish, Russian ulica "street", originally "narrow opening"; Old Church Slavonic uliji, Lithuanian aulys "beehive" (hollow trunk), Armenian yli "pregnant"). The word was extended ...
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Dental Lamina
The dental lamina is a band of epithelial tissue seen in histologic sections of a developing tooth. The dental lamina is first evidence of tooth development and begins (in humans) at the sixth week in utero or three weeks after the rupture of the buccopharyngeal membrane. It is formed when cells of the oral ectoderm proliferate faster than cells of other areas. Best described as an in-growth of oral ectoderm, the dental lamina is frequently distinguished from the vestibular lamina, which develops concurrently. This dividing tissue is surrounded by and, some would argue, stimulated by ectomesenchymal growth. When it is present, the dental lamina connects the developing tooth bud to the epithelium of the oral cavity. Eventually, the dental lamina disintegrates into small clusters of epithelium and is resorbed. In situations when the clusters are not resorbed, (this remnant of the dental lamina is sometimes known as the glands of Serres) eruption cysts are formed over the devel ...
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Molar (tooth)
The molars or molar teeth are large, flat teeth at the back of the mouth. They are more developed in mammals. They are used primarily to grind food during chewing. The name ''molar'' derives from Latin, ''molaris dens'', meaning "millstone tooth", from ''mola'', millstone and ''dens'', tooth. Molars show a great deal of diversity in size and shape across the mammal groups. The third molar of humans is sometimes vestigial. Human anatomy In humans, the molar teeth have either four or five cusps. Adult humans have 12 molars, in four groups of three at the back of the mouth. The third, rearmost molar in each group is called a wisdom tooth. It is the last tooth to appear, breaking through the front of the gum at about the age of 20, although this varies among individuals and populations, and in many cases the tooth is missing. The human mouth contains upper (maxillary) and lower (mandibular) molars. They are: maxillary first molar, maxillary second molar, maxillary third mol ...
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Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differe ...
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Gecko
Geckos are small, mostly carnivorous lizards that have a wide distribution, found on every continent except Antarctica. Belonging to the infraorder Gekkota, geckos are found in warm climates. They range from . Geckos are unique among lizards for their vocalisations, which differ from species to species. Most geckos in the family Gekkonidae use chirping or clicking sounds in their social interactions. Tokay geckos (''Gekko gecko'') are known for their loud mating calls, and some other species are capable of making hissing noises when alarmed or threatened. They are the most species-rich group of lizards, with about 1,500 different species worldwide. All geckos, except species in the family Eublepharidae lack eyelids; instead, the outer surface of the eyeball has a transparent membrane, the brille. They have a fixed lens within each iris that enlarges in darkness to let in more light. Since they cannot blink, species without eyelids generally lick their own brilles whe ...
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Schultz's Rule
Schultz's rule is a rule developed by Adolph Hans Schultz, declaring a relationship between the first tooth eruption of the molar versus the permanent teeth and the progress or aging of its carrier. It states that species that live longer have more wear on deciduous teeth and as a result start replacing them relatively early in life. Which is an indicator for examining fossil data. According to research, '' Myotragus balearicus'' follows Schultz's Rule. See also * Diphyodont * Polyphyodont * Tooth development A tooth (: teeth) is a hard, calcified structure found in the jaws (or mouths) of many vertebrates and used to break down food. Some animals, particularly carnivores and omnivores, also use teeth to help with capturing or wounding prey, teari ... References Further reading * * Tooth development Animal anatomy Paleontological concepts and hypotheses {{dentistry-stub ...
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Diphyodont
A diphyodont is any animal with two sets of teeth, initially the ''deciduous'' set and consecutively the '' permanent'' set. Most mammals are diphyodonts—as to chew their food they need a strong, durable and complete set of teeth. Diphyodonts contrast with ''polyphyodonts'', whose teeth are constantly replaced. Diphyodonts also differ from '' monophyodonts'', which are animals who have only one set of teeth that does not change over a long period of growth. In diphyodonts, the number of teeth that are replaced varies from species to species. In humans, a set of twenty deciduous teeth, or "milk teeth", are replaced by a completely new set of thirty-two adult teeth. In some cases hypodontia or hyperdontia occurs, the latter in cleidocranial dysostosis and Gardner's syndrome. In the hare the anterior incisors are not replaced but the posterior smaller incisors are replaced. Not much is known about the developmental mechanisms regulating diphyodont replacement. The house shre ...
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Arthropods
Arthropods ( ) are invertebrates in the phylum Arthropoda. They possess an arthropod exoskeleton, exoskeleton with a cuticle made of chitin, often Mineralization (biology), mineralised with calcium carbonate, a body with differentiated (Metamerism (biology), metameric) Segmentation (biology), segments, and paired jointed appendages. In order to keep growing, they must go through stages of moulting, a process by which they shed their exoskeleton to reveal a new one. They form an extremely diverse group of up to ten million species. Haemolymph is the analogue of blood for most arthropods. An arthropod has an open circulatory system, with a body cavity called a haemocoel through which haemolymph circulates to the interior Organ (anatomy), organs. Like their exteriors, the internal organs of arthropods are generally built of repeated segments. They have ladder-like nervous systems, with paired Anatomical terms of location#Dorsal and ventral, ventral Ventral nerve cord, nerve cord ...
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