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Pallidum
The globus pallidus (GP), also known as paleostriatum or dorsal pallidum, is a major component of the subcortical basal ganglia in the brain. It consists of two adjacent segments, one external (or lateral), known in rodents simply as the globus pallidus, and one internal (or medial). It is part of the telencephalon, but retains close functional ties with the subthalamus in the diencephalon – both of which are part of the extrapyramidal motor system. The globus pallidus receives principal inputs from the striatum, and principal direct outputs to the thalamus and the substantia nigra. The latter is made up of similar neuronal elements, has similar afferents from the striatum, similar projections to the thalamus, and has a similar synaptology. Neither receives direct cortical afferents, and both receive substantial additional inputs from the intralaminar thalamic nuclei. Globus pallidus is Latin for "pale globe". Structure Pallidal nuclei are made up of the same neuronal compo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Striatopallidonigral Bundle
The basal ganglia form a major brain system in all vertebrates, but in primates (including humans) there are special differentiating features. The basal ganglia include the striatum, globus pallidus, substantia nigra and subthalamic nucleus. In primates the pallidus is divided into an external and internal globus pallidus, the external globus pallidus is present in other mammals but not the internal globus pallidus. Also in primates, the dorsal striatum is divided by a large nerve tract called the internal capsule into two masses named the caudate nucleus and the putamen. These differences contribute to a complex circuitry of connections between the striatum and cortex that is specific to primates, reflecting different functions in primate cortical areas. Corticostriatal connection A major output from the cortex, with axons from most of the cortical regions connecting to the striatum, is called the corticostriatal connection, part of the cortico-basal ganglia-thalamo-cortical loo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basal Ganglia
The basal ganglia (BG) or basal nuclei are a group of subcortical Nucleus (neuroanatomy), nuclei found in the brains of vertebrates. In humans and other primates, differences exist, primarily in the division of the globus pallidus into external and internal regions, and in the division of the striatum. Positioned at the base of the forebrain and the top of the midbrain, they have strong connections with the cerebral cortex, thalamus, brainstem and other brain areas. The basal ganglia are associated with a variety of functions, including regulating voluntary motor control, motor movements, procedural memory, procedural learning, habituation, habit formation, conditional learning, eye movements, cognition, and emotion. The main functional components of the basal ganglia include the striatum, consisting of both the dorsal striatum (caudate nucleus and putamen) and the ventral striatum (nucleus accumbens and olfactory tubercle), the globus pallidus, the ventral pallidum, the substa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleus Accumbens
The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the ''nucleus accumbens septi'', Latin for ' nucleus adjacent to the septum') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus. The nucleus accumbens and the olfactory tubercle collectively form the ventral striatum. The ventral striatum and dorsal striatum collectively form the striatum, which is the main component of the basal ganglia. The dopaminergic neurons of the mesolimbic pathway project onto the GABAergic medium spiny neurons of the nucleus accumbens and olfactory tubercle. Each cerebral hemisphere has its own nucleus accumbens, which can be divided into two structures: the nucleus accumbens core and the nucleus accumbens shell. These substructures have different morphology and functions. Different NAcc subregions (core vs shell) and neuron subpopulations within each region ( D1-type vs D2-type medium spiny neurons) are responsible fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ventral Pallidum
The ventral pallidum (VP) is a structure within the basal ganglia of the brain. It is an output nucleus whose fibres project to thalamic nuclei, such as the ventral anterior nucleus, the ventral lateral nucleus, and the medial dorsal nucleus. The VP is a core component of the reward system which forms part of the limbic loop of the basal ganglia, a pathway involved in the regulation of motivational salience, behavior, and emotions. It is involved in addiction. The VP contains one of the brain's pleasure centers, which mediates the subjective perception of pleasure that results from "consuming" certain rewarding stimuli (e.g., palatable food). Anatomy The ventral pallidum lies within the basal ganglia, a group of subcortical nuclei. Along with the external globus pallidus, it is separated from other basal ganglia nuclei by the anterior commissure. The ventral pallidum contains GABAergic neurons, glutamatergic neurons, and cholinergic neurons that are well conserved ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olfactory Tubercle
The olfactory tubercle (OT), also known as the tuberculum olfactorium, is a multi-sensory processing center that is contained within the olfactory cortex and ventral striatum and plays a role in reward cognition. The OT has also been shown to play a role in locomotor and attentional behaviors, particularly in relation to social and sensory responsiveness, and it may be necessary for behavioral flexibility. The OT is interconnected with numerous brain regions, especially the sensory, arousal, and reward centers, thus making it a potentially critical interface between processing of sensory information and the subsequent behavioral responses. The OT is a composite structure that receives direct input from the olfactory bulb and contains the morphological and histochemical characteristics of the ventral pallidum and the striatum of the forebrain. The dopaminergic neurons of the mesolimbic pathway project onto the GABAergic medium spiny neurons of the nucleus accumbens and olfa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Striatum
The striatum (: striata) or corpus striatum is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia. Functionally, the striatum coordinates multiple aspects of cognition, including both motor and action planning, decision-making, motivation, reinforcement, and reward perception. The striatum is made up of the caudate nucleus and the lentiform nucleus. However, some authors believe it is made up of caudate nucleus, putamen, and ventral striatum. The lentiform nucleus is made up of the larger putamen, and the smaller globus pallidus. Strictly speaking the globus pallidus is part of the striatum. It is common practice, however, to implicitly exclude the globus pallidus when referring to striatal structures. In pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substantia Innominata
The substantia innominata, also innominate substance or substantia innominata of Meynert (Latin for unnamed substance), is a series of layers in the human brain consisting partly of gray and partly of white matter, which lies below the anterior part of the thalamus and lentiform nucleus. It is included as part of the anterior perforated substance (as it appears to be perforated by many holes which are actually blood vessels). It is part of the basal forebrain structures and includes the nucleus basalis. A portion of the substantia innominata, below the globus pallidus is considered as part of the extended amygdala. Layers It consists of three layers, superior, middle, and inferior. * The ''superior layer'' is named the ansa lenticularis, and its fibers, derived from the medullary lamina of the lentiform nucleus, pass medially to end in the thalamus and subthalamic region, while others are said to end in the tegmentum and red nucleus. * The ''middle layer'' consists of nerve cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain
The brain is an organ (biology), organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head (cephalization), usually near organs for special senses such as visual perception, vision, hearing, and olfaction. Being the most specialized organ, it is responsible for receiving information from the sensory nervous system, processing that information (thought, cognition, and intelligence) and the coordination of motor control (muscle activity and endocrine system). While invertebrate brains arise from paired segmental ganglia (each of which is only responsible for the respective segmentation (biology), body segment) of the ventral nerve cord, vertebrate brains develop axially from the midline dorsal nerve cord as a brain vesicle, vesicular enlargement at the rostral (anatomical term), rostral end of the neural tube, with centralized control over all body segments. All vertebr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dystonia
Dystonia is a neurology, neurological Hyperkinesia, hyperkinetic Movement disorders, movement disorder in which sustained or repetitive muscle contractions occur involuntarily, resulting in twisting and repetitive movements or abnormal fixed postures. The movements may resemble a tremor. Dystonia is often intensified or exacerbated by physical activity, and symptoms may progress into adjacent muscles. The disorder may be Heredity, hereditary or caused by other factors such as birth trauma (physical), birth-related or other Injury, physical trauma, infection, poisoning (e.g., lead poisoning) or reaction to Medication, pharmaceutical drugs, particularly Antipsychotic, neuroleptics, or stress. Treatment must be highly customized to the needs of the individual and may include oral medications, chemodenervation Botulinum toxin, botulinum neurotoxin injections, physical therapy, or other supportive therapies, and surgical procedures such as deep brain stimulation. Classification The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tegmentum
The tegmentum (from Latin for "covering") is a general area within the brainstem. The tegmentum is the ventral part of the midbrain and the tectum is the dorsal part of the midbrain. It is located between the ventricular system and distinctive basal or ventral structures at each level. It forms the floor of the midbrain (mesencephalon) whereas the tectum forms the ceiling. It is a multisynaptic network of neurons that is involved in many subconscious homeostatic and reflexive pathways. It is a motor center that relays inhibitory signals to the thalamus and basal nuclei preventing unwanted body movement. The tegmentum area includes various different structures, such as the rostral end of the reticular formation, several nuclei controlling eye movements, the periaqueductal gray matter, the red nucleus, the substantia nigra, and the ventral tegmental area. The tegmentum is the location of several cranial nerve nuclei. The nuclei of CN III and IV are located in the tegmentum port ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pedunculopontine Nucleus
The pedunculopontine nucleus (PPN) or pedunculopontine tegmental nucleus (PPT or PPTg) is a collection of neurons located in the upper pons in the brainstem. It is involved in voluntary movements, arousal, and provides sensory feedback to the cerebral cortex and one of the main components of the ascending reticular activating system. It is a potential target for deep brain stimulation treatment for Parkinson's disease. It was first described in 1909 by Louis Jacobsohn-Lask, a German neuroanatomist. Structure and projections The pedunculopontine nucleus lies below the red nucleus, caudal to the substantia nigra and adjacent to the superior cerebellar peduncle. It has two divisions of subnuclei; the pars compacta, containing mainly cholinergic neurons, and the pars dissipata, containing mainly glutamatergic neurons and some non-cholinergic neurons. Its neurons project axons to a wide range of areas in the brain, particularly parts of the basal ganglia such as the subthalamic nuc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
