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Microtia
Microtia is a congenital deformity where the auricle (external ear) is underdeveloped. A completely undeveloped pinna is referred to as anotia. Because microtia and anotia have the same origin, it can be referred to as microtia-anotia. Microtia can be unilateral (one side only) or bilateral (affecting both sides). Microtia occurs in 1 out of about 8,000–10,000 births. In unilateral microtia, the right ear is most commonly affected. It may occur as a complication of taking Accutane (isotretinoin) during pregnancy. Classification According to the Altman-classification, there are four grades of microtia: *Grade I: A less than complete development of the external ear with identifiable structures and a small but present external ear canal *Grade II: A partially developed ear (usually the top portion is underdeveloped) with a closed stenotic external ear canal producing a conductive hearing loss. *Grade III: Absence of the external ear with a small peanut-like vestige structure a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anotia
Anotia ("no ear") describes a rare congenital deformity that involves the complete absence of the pinna, the outer projected portion of the ear, and narrowing or absence of the ear canal. This contrasts with microtia, in which a small part of the pinna is present. Anotia and microtia may occur unilaterally (only one ear affected) or bilaterally (both ears affected). This deformity results in conductive hearing loss, deafness. Ear development Ear development begins in about the third week of human embryonic development, beginning with the formation of the Otic Placodes, an extension of the early hind brain. By the fourth week of development the otic placodes invaginate, or sink inward forming pits which close themselves off for the outer surface ectoderm and begin forming the inner ear labyrinthe on the inside. Outer ear development begins in about the fifth week of human embryonic development. Upon the pharyngeal arches Auricle Hillocks begin to form. By the seventh week the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Reinisch
John Reinisch is an American physician specializing in plastic surgery. He is a pioneer in the field of pediatric plastic surgery, and developed the Medpor method of ear reconstruction for treatment of microtia. He founded the division of plastic surgery at Children's Hospital Los Angeles in 1983 and was also chairman of the division of plastic surgery at the University of Southern California, where he remains on the faculty. He is currently the director of Craniofacial and Pediatric Plastic Surgery at Cedars-Sinai Medical Center and a plastic surgeon at Cedars-Sinai Medical Group. He is also director of the Center for Ear Reconstruction. He developed many of the techniques currently in use for treatment of microtia, cleft lip and palate, wound care, post operative pain relief, vascular and pigmented birth marks, and the use of tissue expansion in children. He has an international practice that was built in part on his early adoption of the use of telemedicine. Dr. Reinisch work ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Stanley
Paul Stanley (born Stanley Bert Eisen; January 20, 1952) is an American musician who is the co-founder, frontman, rhythm guitarist and co-lead vocalist of the hard rock band Kiss. He is the writer or co-writer of many of the band's most popular songs. Stanley established The Starchild character for his Kiss persona. Stanley was inducted into the Rock and Roll Hall of Fame in 2014 as a member of Kiss. In 2006, ''Hit Parader'' ranked him 18th on their list of the Top 100 Metal Vocalists of All Time. A Gibson.com readers' poll in 2010 named him 13th on their list of Top 25 Frontmen. Early life Stanley Bert Eisen was born January 20, 1952, in upper Manhattan, New York City, near 211th St. and Broadway; the Inwood neighborhood near Inwood Hill Park. Both of his parents are Jewish. He was the second of two children; his sister Julia was born two years earlier. Their mother came from a family that fled Nazi Germany to Amsterdam, Netherlands, and then to New York City. His father' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atresia
Atresia is a condition in which an orifice or passage in the body is (usually abnormally) closed or absent. Examples of atresia include: *Aural atresia, a congenital deformity where the ear canal is underdeveloped. * Biliary atresia, a condition in newborns in which the common bile duct between the liver and the small intestine is blocked or absent. * Congenital bronchial atresia, a rare congenital abnormality * Choanal atresia, blockage of the back of the nasal passage, usually by abnormal bony or soft tissue. * Esophageal atresia, which affects the alimentary tract and causes the esophagus to end before connecting normally to the stomach. *Follicular atresia, degeneration and resorption of the ovarian follicles. * Imperforate anus, malformation of the opening between the rectum and anus. * Intestinal atresia, malformation of the intestine, usually resulting from a vascular accident in utero. * Microtia, absence of the ear canal or failure of the canal to be tubular or fully fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Auricle (anatomy)
The auricle or auricula is the visible part of the ear that is outside the head. It is also called the pinna ( Latin for " wing" or "fin", plural pinnae), a term that is used more in zoology. Structure The diagram shows the shape and location of most of these components: * ''antihelix'' forms a 'Y' shape where the upper parts are: ** ''Superior crus'' (to the left of the ''fossa triangularis'' in the diagram) ** ''Inferior crus'' (to the right of the ''fossa triangularis'' in the diagram) * ''Antitragus'' is below the ''tragus'' * ''Aperture'' is the entrance to the ear canal * ''Auricular sulcus'' is the depression behind the ear next to the head * ''Concha'' is the hollow next to the ear canal * Conchal angle is the angle that the back of the ''concha'' makes with the side of the head * ''Crus'' of the helix is just above the ''tragus'' * ''Cymba conchae'' is the narrowest end of the ''concha'' * External auditory meatus is the ear canal * ''Fossa triangularis'' is the de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Treacher-Collins Syndrome
Treacher Collins syndrome (TCS) is a genetic disorder characterized by deformities of the ears, eyes, cheekbones, and chin. The degree to which a person is affected, however, may vary from mild to severe. Complications may include breathing problems, problems seeing, cleft palate, and hearing loss. Those affected generally have normal intelligence. TCS is usually autosomal dominant. More than half the time it occurs as a result of a new mutation rather than being inherited from a person's parents. The involved genes may include ''TCOF1'', '' POLR1C'', or ''POLR1D''. Diagnosis is generally suspected based on symptoms and X-rays, and potentially confirmation by genetic testing. Treacher Collins syndrome is not curable. Symptoms may be managed with reconstructive surgery, hearing aids, speech therapy, and other assistive devices. Life expectancy is generally normal. TCS occurs in about one in 50,000 people. The syndrome is named after Edward Treacher Collins, an English surg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Goldenhar Syndrome
Goldenhar syndrome is a rare congenital defect characterized by incomplete development of the ear, nose, soft palate, lip and mandible on usually one side of the body. Common clinical manifestations include limbal dermoids, preauricular skin tags and strabismus. It is associated with anomalous development of the first branchial arch and second branchial arch. The term is sometimes used interchangeably with hemifacial microsomia, although this definition is usually reserved for cases without internal organ and vertebrae disruption. It affects between 1 in 3,500 and 1 in 5,600 live births, with a male-to-female ratio of 3:2. Signs and symptoms Chief markers of Goldenhar syndrome are incomplete development of the ear, nose, soft palate, lip, and mandible on usually one side of the body. Additionally, some patients will have growing issues with internal organs, especially heart, kidneys and lungs. Typically, the organ will either not be present on one side or will be underdevel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemifacial Microsomia
Hemifacial microsomia (HFM) is a congenital disorder that affects the development of the lower half of the face, most commonly the ears, the mouth and the mandible. It usually occurs on one side of the face, but both sides are sometimes affected. If severe, it may result in difficulties in breathing due to obstruction of the trachea—sometimes even requiring a tracheotomy. With an incidence in the range of 1:3500 to 1:4500, it is the second most common birth defect of the face, after cleft lip and cleft palate. HFM shares many similarities with Treacher Collins syndrome. Presentation The clinical presentation of HFM is quite variable. The severity may depend on the extent of the area with an insufficient blood supply ''in utero'', and the gestational age of the fetus at which this occurs. In some people, the only physical manifestation may be a small and underdeveloped external ear. In more severe cases, multiple parts of the face may be affected. Some people with HFM may have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3D Bioprinting
Three dimensional (3D) bioprinting is the utilization of 3D printing–like techniques to combine cells, growth factors, and/or biomaterials to fabricate biomedical parts, often with the aim of imitating natural tissue characteristics. Generally, 3D bioprinting can utilize a layer-by-layer method to deposit materials known as bio-inks to create tissue-like structures that are later used in various medical and tissue engineering fields. 3D bioprinting covers a broad range of bioprinting techniques and biomaterials. Currently, bioprinting can be used to print tissue and organ models to help research drugs and potential treatments. Nonetheless, translation of bioprinted living cellular constructs into clinical application is met with several issues due to the complexity and cell number needed to create functional organs. However, innovations span from bioprinting of extracellular matrix to mixing cells with hydrogels deposited layer by layer to produce the desired tissue. In addition, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Various Types 2 (detail B)
Various may refer to: * Various (band), an English dubstep/electronic music duo * Various artists, a term for a compilation album containing pieces by various musicians * Various authors, a book containing works by several writers * ''The Various'', a children's fantasy novel by Steve Augarde See also * Various & Gould, a Berlin-based artist duo * '' Various Artists – Archives Vol. 4'', an album by Steve Vai * ''Various Failures'', a compilation album by American experimental rock band Swans * ''The Various Haunts of Men'', a novel by Susan Hill * '' Various Positions'', an album by Leonard Cohen ** Various Positions Tour Various may refer to: * Various (band), an English dubstep/electronic music duo * Various artists, a term for a compilation album containing pieces by various musicians * Various authors, a book containing works by several writers * ''The Various' ... * ''Various Positions'' (film), a 2002 film directed by Ori Kowarsky * Varius (other) * [Baidu] |
Titanium
Titanium is a chemical element with the Symbol (chemistry), symbol Ti and atomic number 22. Found in nature only as an oxide, it can be reduced to produce a lustrous transition metal with a silver color, low density, and high strength, resistant to corrosion in sea water, aqua regia, and chlorine. Titanium was discovered in Cornwall, Kingdom of Great Britain, Great Britain, by William Gregor in 1791 and was named by Martin Heinrich Klaproth after the Titan (mythology), Titans of Greek mythology. The element occurs within a number of minerals, principally rutile and ilmenite, which are widely distributed in the Earth's crust and lithosphere; it is found in almost all living things, as well as bodies of water, rocks, and soils. The metal is extracted from its principal mineral ores by the Kroll process, Kroll and Hunter process, Hunter processes. The most common compound, titanium dioxide, is a popular photocatalysis, photocatalyst and is used in the manufacture of white pigments ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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