Mezlocillin
Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending cholangitis. Mechanism of action Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis. Susceptible organisms Gram-negative *''Bacteroides'' spp., including ''B. fragilis'' *''Enterobacter'' spp. *''Escherichia coli'' *''Haemophilus influenzae'' *''Klebsiella'' species *'' Morganella morganii'' *'' Neisseria gonorrhoeae'' *''Proteus mirabilis'' *''Proteus vulgaris'' *'' Providencia rettgeri'' *''Pseudomonas'' spp., including '' P. aeruginosa'' *''Serratia marcescens'' Gram-positive *''Enterococcus faecalis'' *'' Peptococcus'' spp.'' *''Peptostreptococcus'' spp. ...
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