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Meprobamate
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious side effects. History Frank Berger was working in a laboratory of a British drug company, looking for a preservative for penicillin, when he noticed that a compound called mephenesin calmed laboratory rodents without actually sedating them. Berger subsequently referred to this “tranquilizing” effect in a now-historic article, published by the ''British Journal of Pharmacology'' in 1946. However, three major drawbacks existed to the use of mephenesin as a tranquilizer: a very short duration of action, greater effect on the spinal cord than on the brain (resulting in a very low therapeutic index), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank Berger
Frank Milan Berger (June 25, 1913 - March 18, 2008) was a Czechoslovakian pharmacologist who discovered meprobamate, carisoprodol, and felbamate, while working at Wallace Laboratories. He also discovered the 'tranquilising' effects of mephenesin in rodents while working at a laboratory in the United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the European mainland, continental mainland. It comprises England, Scotlan ..., and campaigned against the advertising of medications in the mass media. References {{DEFAULTSORT:Berger, Frank 1913 births 2008 deaths Scientists from Plzeň Czechoslovak pharmacologists Charles University alumni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbamate
In organic chemistry, a carbamate is a category of organic compounds with the general formula and structure , which are formally derived from carbamic acid (). The term includes organic compounds (e.g., the ester ethyl carbamate), formally obtained by replacing one or more of the hydrogen atoms by other organic functional groups; as well as salts with the carbamate anion (e.g. ammonium carbamate). Polymers whose units are joined by carbamate groups are an important family of plastics, the polyurethanes. Properties While carbamic acids are unstable, many carbamate esters or ionic) are stable and well known. Equilibrium with carbonate and bicarbonate In water solutions, the carbamate anion slowly equilibrates with the ammonium cation and the carbonate or bicarbonate anions: : : Calcium carbamate is soluble in water, whereas calcium carbonate is not. Adding a calcium salt to an ammonium carbamate/carbonate solution will precipitate some calcium carbonat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milltown, New Jersey
Milltown is a borough in Middlesex County, New Jersey, United States. The borough is nestled within the heart of the Raritan Valley region, with Lawrence Brook (a Raritan river tributary) flowing through the center of the community. As of the 2010 United States Census, the borough's population was 6,893,DP-1 - Profile of General Population and Housing Characteristics: 2010 for Milltown borough, Middlesex County, New Jersey , . Accessed December 19, 2011. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mephenesin
Mephenesin (INN) is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. Mephenesin was used by Bernard Ludwig and Frank Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in Italy and a few other countries. Its use has largely been replaced by the related drug methocarbamol, which is better absorbed. Mephenesin may be an NMDA receptor antagonist. Mephenesin was previously used in France as an OTC muscle relaxant called Décontractyl but was taken out of production by Sanofi Aventis and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the right upper quadrant of the abdomen, below the diaphragm. Its other roles in metabolism include the regulation of glycogen storage, decomposition of red blood cells, and the production of hormones. The liver is an accessory digestive organ that produces bile, an alkaline fluid containing cholesterol and bile acids, which helps the breakdown of fat. The gallbladder, a small pouch that sits just under the liver, stores bile produced by the liver which is later moved to the small intestine to complete digestion. The liver's highly specialized tissue, consisting mostly of hepatocytes, regulates a wide variety of high-volume biochemical reactions, including the synthesis and breakdown of small and complex molecu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Michigan
, mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As of October 25, 2021. , president = Santa Ono , provost = Laurie McCauley , established = , type = Public research university , academic_affiliations = , students = 48,090 (2021) , undergrad = 31,329 (2021) , postgrad = 16,578 (2021) , administrative_staff = 18,986 (2014) , faculty = 6,771 (2014) , city = Ann Arbor , state = Michigan , country = United States , coor = , campus = Midsize City, Total: , including arboretum , colors = Maize & Blue , nickname = Wolverines , sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbizon Plaza Hotel
Trump Parc and Trump Parc East are two adjoining buildings at the southwest corner of Central Park South and Sixth Avenue in Midtown Manhattan, New York City. Trump Parc (the former Barbizon-Plaza Hotel) is a 38-story condominium building, and Trump Parc East is a 14-story apartment and condominium building. Trump Parc: Barbizon Plaza Hotel The 38-story art deco Barbizon-Plaza Hotel opened at 106 Central Park South on May 12, 1930 with 1,400 ensuite rooms. It was built for $10 million by William H. Silk, owner of the Barbizon Hotel. The architect was Laurence Emmons. The hotel was designed to appeal to artists and musicians, with facilities including soundproof practice rooms, art studios, and two performance halls. The property was foreclosed on in 1933. At some point, likely around World War II, the top of the building was altered to its present form with a stylish design. Carter B. Horsley of ''The City Review'' said, "Its only rivals in audacity are the Chrysler Building a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the United States, and is more than twice as populous as second-place Los Angeles. New York City lies at the southern tip of New York State, and constitutes the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the world by urban landmass. With over 20.1 million people in its metropolitan statistical area and 23.5 million in its combined statistical area as of 2020, New York is one of the world's most populous megacities, and over 58 million people live within of the city. New York City is a global cultural, financial, entertainment, and media center with a significant influence on commerce, health care and life sciences, research, technology, educa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aldous Huxley
Aldous Leonard Huxley (26 July 1894 – 22 November 1963) was an English writer and philosopher. He wrote nearly 50 books, both novels and non-fiction works, as well as wide-ranging essays, narratives, and poems. Born into the prominent Huxley family, he graduated from Balliol College, Oxford, with an undergraduate degree in English literature. Early in his career, he published short stories and poetry and edited the literary magazine '' Oxford Poetry'', before going on to publish travel writing, satire, and screenplays. He spent the latter part of his life in the United States, living in Los Angeles from 1937 until his death. By the end of his life, Huxley was widely acknowledged as one of the foremost intellectuals of his time. He was nominated for the Nobel Prize in Literature nine times, and was elected Companion of Literature by the Royal Society of Literature in 1962. Huxley was a pacifist. He grew interested in philosophical mysticism, as well as universalism, addre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milton Berle
Milton Berle (born Mendel Berlinger; ; July 12, 1908 – March 27, 2002) was an American actor and comedian. His career as an entertainer spanned over 80 years, first in silent films and on stage as a child actor, then in radio, movies and television. As the host of NBC's '' Texaco Star Theatre'' (1948–1953), he was the first major American television star and was known to millions of viewers as "Uncle Miltie" and "Mr. Television" during the first Golden Age of Television. He was honored with two stars on the Hollywood Walk of Fame for his work in both radio and TV. Early life Milton Berle was born into a Jewish family in a five-story walkup at 68 W. 118th Street in the Harlem neighborhood of Manhattan. His given name was Mendel Berlinger, but he chose Milton Berle as his professional name when he was 16. His father, Moses Berlinger (1872–1938), was a paint and varnish salesman. His mother, Sarah (Sadie) Glantz Berlinger (1877–1954), changed her name to Sandra Berle wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts. It is a structure composed of nervous tissue positioned along the rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain (precursor structures exist in onychophorans, gastropods and lancelets). The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal cord are both enclosed in the meninges. The meninges provide a barrier to chemicals d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elvis Presley
Elvis Aaron Presley (January 8, 1935 – August 16, 1977), or simply Elvis, was an American singer and actor. Dubbed the "Honorific nicknames in popular music, King of Rock and Roll", he is regarded as Cultural impact of Elvis Presley, one of the most significant cultural figures of the 20th century. His energized interpretations of songs and sexually provocative performance style, combined with a singularly potent mix of influences across color lines during a civil rights movement, transformative era in race relations, led him to both great success and Cultural impact of Elvis Presley#Danger to American culture, initial controversy. Presley was born in Tupelo, Mississippi, and relocated to Memphis, Tennessee, with his family when he was 13 years old. His music career began there in 1954, recording at Sun Records with producer Sam Phillips, who wanted to bring the sound of African-American music to a wider audience. Presley, on rhythm acoustic guitar, and accompanied by lead ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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