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Isoquercetin
Isoquercetin, isoquercitrin or isotrifoliin is a flavonoid, a type of chemical compound. It is the 3-''O''-glucoside of quercetin. Isoquercitrin can be isolated from various plant species including ''Mangifera indica'' (mango) and '' Rheum nobile'' (the Noble rhubarb). It is also present in the leaves of '' Annona squamosa'', ''Camellia sinensis'' (tea). and '' Vestia foetida'' Spectral data The lambda-max for isoquercetin is 254.8 and 352.6 nm. Potential clinical uses Isoquercetin is presently being investigated for prevention of thromboembolism in selected cancer patients and as an anti-fatigue Fatigue is a state of tiredness (which is not sleepiness), exhaustion or loss of energy. It is a signs and symptoms, symptom of any of various diseases; it is not a disease in itself. Fatigue (in the medical sense) is sometimes associated wit ... agent in kidney cancer patients treated with sunitinib. There is a single case report of its use in the successful treatment of p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vestia Foetida
''Vestia'' is a monotypic genusLas Penas, M. L., et al. (2006)Karyotypes of some species of ''Cestrum'', ''Sessea'', and ''Vestia'' (tribe Cestreae, Solanaceae).''Caryologia'' 59(2) 131-37. of flowering plants in the family (biology), family Solanaceae containing the single species ''Vestia foetida'' (synonym (taxonomy), syn. ''V. lycioides''). Its principal common names in the Mapudungun language of its native Chile are Huevil (pron. "wayfil" and sometimes redoubled Huevilhuevil) and Chuplín. Other Chilean names include Chuplí, Echuelcún and Palqui (negro) (this last being also applied to ''Cestrum parqui''),C. Brevis, M. Quezada, P. Bustamante, L. Carrasco, A. Ruiz, S. Donoso, Huevil (Vestia foetida) poisoning of cattle in Chile ''The Veterinary record'' 156(14):452-3 May 2005 https://www.researchgate.net/publication/7907806_Huevil_Vestia_foetida_poisoning_of_cattle_in_Chile Retrieved at 10.35 on 14/7/20.Chilebosque http://www.chilebosque.cl/shrb/vestia_foetida.html Retrieved ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quercitrin
Quercitrin is a glycoside formed from the flavonoid quercetin and the deoxy sugar rhamnose. Austrian chemist Heinrich Hlasiwetz (1825-1875) is remembered for his chemical analysis of quercitrin. It has also been investigated as a potential dietary supplement. Occurrence Quercitrin is a constituent of the dye quercitron. It can be found in Tartary buckwheat (''Fagopyrum tataricum'') and in oaks species like the North American white oak (''Quercus alba'') and English oak (''Quercus robur ''Quercus robur'', the pedunculate oak, is a species of flowering plant in the beech and oak family, Fagaceae. It is a large tree, native plant, native to most of Europe and western Asia, and is widely cultivated in other temperate regions. It ...'').Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry. Pirjo Mämmelä, Heikki Savolainen, Lasse Lindroos, Juhani Kangas and Terttu Vartiainen, Journal of Chromatography A, Volume 891, Issue 1, 1 Septe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pan-assay Interference Compounds
Pan-assay interference compounds (PAINS) are chemical compounds that often give false positive results in high-throughput screens. PAINS tend to react nonspecifically with numerous biological targets rather than specifically affecting one desired target. A number of disruptive functional groups are shared by many PAINS. While a number of filters have been proposed and are used in virtual screening and computer-aided drug design, the accuracy of filters with regard to compounds they flag and don't flag has been criticized. Common PAINS include toxoflavin, isothiazolones, hydroxyphenyl hydrazones, curcumin, phenol-sulfonamides, rhodanines, enones, quinones, and catechols such as luteolin and various other flavonoids. See also *Drug discovery In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prurigo Nodularis
Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic (itchy), nodular lesions, which commonly appear on the trunk, arms and legs. Patients often present with multiple excoriated nodules caused by chronic scratching. Although the exact cause of PN is unknown, PN is associated with other dermatologic conditions such as untreated or severe atopic dermatitis and systemic causes of pruritus including liver disease and end stage kidney disease. The goal of treatment in PN is to decrease itching. PN is also known as ''Hyde prurigo nodularis'', or ''Picker's nodules.'' Signs and symptoms * Nodules are discrete, generally symmetric, hyperpigmented and firm. They are greater than 0.5 cm in both width and depth (as opposed to papules which are less than 0.5 cm). * The nodules of PN can appear on any part of the body, but generally are found in areas where patients are able to reach to scratch. Patients can exhibit a 'butterfly sign ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sunitinib
Sunitinib, sold under the brand name Sutent, is an anti-cancer medication. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) in January 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications. As of August 2021, sunitinib is available as a generic medicine in the US. Medical uses Gastrointestinal stromal tumor Like renal cell carcinoma, gastrointestinal stromal tumors do not generally respond to standard chemotherapy or radiation. Imatinib was the first chemotherapeutic agent proven effective for metastatic gastrointestinal stromal tumors and represented a significant development in the treatment of this rare but challenging disease. However, approximately 20% of patients do not respond to imatinib (early or primary resistance), and among those who do respond init ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatigue (medical)
Fatigue is a state of tiredness (which is not sleepiness), exhaustion or loss of energy. It is a symptom of any of various diseases; it is not a disease in itself. Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease, organ failure, chronic pain conditions, mood disorders, heart disease, infectious diseases, and post-infectious-disease states. However, fatigue is complex and in up to a third of primary care cases no medical or psychiatric diagnosis is found. Fatigue (in the general usage sense of normal tiredness) often follows prolonged physical or mental activity. Physical fatigue results from muscle fatigue brought about by intense physical activity. Mental fatigue results from prolonged periods of cognitive activity which impairs cognitive ability, can manifest as sleepiness, lethargy, or directed attention fatigue, and can also impair physical performance. Definition Fatigue in a medical context is used to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thromboembolism
Thromboembolism is a condition in which a blood clot (thrombus) breaks off from its original site and travels through the bloodstream (as an embolus) to obstruct a blood vessel, causing tissue ischemia and organ damage. Thromboembolism can affect both the venous and arterial systems, with different clinical manifestations and management strategies. Venous thromboembolism Venous thromboembolism (VTE) comprises the following conditions: * deep vein thrombosis (DVT) , * pulmonary embolism (PE) . VTE is a common cardiovascular disorder with significant morbidity and mortality. Signs and Symptoms VTE can present with various symptoms, such as painful leg swelling, chest pain, dyspnea, hemoptysis, syncope, and even death, depending on the location and extent of the thrombus. VTE can also cause long-term complications, such as recurrent VTE, post-PE syndrome, chronic thromboembolic pulmonary hypertension (CTEPH), and post-thrombotic syndrome (PTS). Treatment The mainstay of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanometre
330px, Different lengths as in respect to the Molecule">molecular scale. The nanometre (international spelling as used by the International Bureau of Weights and Measures; SI symbol: nm), or nanometer (American spelling), is a unit of length in the International System of Units (SI), equal to one billionth ( short scale) or one thousand million (long scale) of a meter (0.000000001 m) and to 1000 picometres. One nanometre can be expressed in scientific notation as 1 × 10−9 m and as m. History The nanometre was formerly known as the "''millimicrometre''" – or, more commonly, the "''millimicron''" for short – since it is of a micrometer. It was often denoted by the symbol ''mμ'' or, more rarely, as ''μμ'' (however, ''μμ'' should refer to a ''millionth'' of a micron). Etymology The name combines the SI prefix '' nano-'' (from the Ancient Greek , ', "dwarf") with the parent unit name ''metre'' (from Greek , ', "unit of measurement"). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PubChem
PubChem is a database of Chemistry, chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH). PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be freely downloaded via FTP. PubChem contains multiple substance descriptions and small molecules with fewer than 100 atoms and 1,000 bonds. More than 80 database vendors contribute to the growing PubChem database. History PubChem was released in 2004 as a component of the Molecular Libraries Program (MLP) of the NIH. As of November 2015, PubChem contains more than 150 million depositor-provided substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results (from over 1 million assay experiments performe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flavonoid
Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a Heterocyclic compound, heterocyclic ring (C, the ring containing the embedded oxygen). This carbon structure can be abbreviated C6-C3-C6. According to the IUPAC nomenclature, they can be classified into: *flavonoids or bioflavonoids *isoflavonoids, derived from 3-phenylchromone, chromen-4-one (3-phenyl-1,4-benzopyran, benzopyrone) structure *neoflavonoids, derived from 4-phenylcoumarin (4-phenyl-1,2-benzopyran, benzopyrone) structure The three flavonoid classes above are all ketone-containing compounds and as such, anthoxanthins (flavones and flavonols). This class was the first to be termed bioflavonoids. The terms flavonoid and bioflavo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camellia Sinensis
''Camellia sinensis'' is a species of evergreen shrub or small tree in the flowering plant family Theaceae. Its leaves, leaf buds, and stems can be used to produce tea. Common names include tea plant, tea shrub, and tea tree (unrelated to ''Melaleuca alternifolia'', the source of tea tree oil, or the genus ''Leptospermum'' commonly called tea tree). White tea, yellow tea, green tea, oolong, dark tea (which includes pu-erh tea) and black tea are all harvested from two of the five varieties which form the main crops now grown, ''C. sinensis'' var. ''sinensis'' and ''C. s.'' var. ''assamica'', but are Tea processing, processed differently to attain varying levels of oxidation with black tea being the most oxidized and white being the least. Kukicha (twig tea) is also harvested from ''C. sinensis'', but uses twigs and stems rather than leaves. Description ''Camellia sinensis'' is native to East Asia, the Indian Subcontinent, and Southeast Asia, but it is today cultivated all aro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
