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Grayanotoxin
Grayanotoxins are a group of closely related neurotoxins named after '' Leucothoe grayana'', a plant native to Japan originally named for 19th century American botanist Asa Gray. Grayanotoxin I (grayanotaxane-3,5,6,10,14,16-hexol 14-acetate) is also known as andromedotoxin, acetylandromedol, rhodotoxin and asebotoxin. Grayanotoxins are produced by ''Rhododendron'' species and other plants in the family Ericaceae. Honey made from the nectar and so containing pollen of these plants also contains grayanotoxins and is commonly referred to as mad honey. Consumption of the plant or any of its secondary products, including mad honey, can cause a rare poisonous reaction called grayanotoxin poisoning, mad honey disease, honey intoxication, or rhododendron poisoning. It is most frequently produced and consumed in regions of Nepal and Turkey as a recreational drug and traditional medicine. Origin Grayanotoxins are produced by plants in the family Ericaceae, specifically members of the gener ...
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Grayanotoxins
Grayanotoxins are a group of closely related neurotoxins named after '' Leucothoe grayana'', a plant native to Japan originally named for 19th century American botanist Asa Gray. Grayanotoxin I (grayanotaxane-3,5,6,10,14,16-hexol 14-acetate) is also known as andromedotoxin, acetylandromedol, rhodotoxin and asebotoxin. Grayanotoxins are produced by ''Rhododendron'' species and other plants in the family Ericaceae. Honey made from the nectar and so containing pollen of these plants also contains grayanotoxins and is commonly referred to as mad honey. Consumption of the plant or any of its secondary products, including mad honey, can cause a rare poisonous reaction called grayanotoxin poisoning, mad honey disease, honey intoxication, or rhododendron poisoning. It is most frequently produced and consumed in regions of Nepal and Turkey as a recreational drug and traditional medicine. Origin Grayanotoxins are produced by plants in the family Ericaceae, specifically members of the ...
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Rhododendron Luteum2
''Rhododendron'' (; from Ancient Greek ''rhódon'' "rose" and ''déndron'' "tree") is a very large genus of about 1,024 species of woody plants in the heath family (Ericaceae). They can be either evergreen or deciduous. Most species are native to eastern Asia and the Himalayan region, but smaller numbers occur elsewhere in Asia, and in North America, Europe and Australia. It is the national flower of Nepal, the state flower of Washington and West Virginia in the United States, the state flower of Nagaland in India, the provincial flower of Jiangxi in China and the state tree of Sikkim and Uttarakhand in India. Most species have brightly colored flowers which bloom from late winter through to early summer. Azaleas make up two subgenera of ''Rhododendron''. They are distinguished from "true" rhododendrons by having only five anthers per flower. Species Description ''Rhododendron'' is a genus of shrubs and small to (rarely) large trees, the smallest species growing to tall ...
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Rhododendron
''Rhododendron'' (; from Ancient Greek ''rhódon'' "rose" and ''déndron'' "tree") is a very large genus of about 1,024 species of woody plants in the heath family (Ericaceae). They can be either evergreen or deciduous. Most species are native to eastern Asia and the Himalayan region, but smaller numbers occur elsewhere in Asia, and in North America, Europe and Australia. It is the national flower of Nepal, the state flower of Washington and West Virginia in the United States, the state flower of Nagaland in India, the provincial flower of Jiangxi in China and the state tree of Sikkim and Uttarakhand in India. Most species have brightly colored flowers which bloom from late winter through to early summer. Azaleas make up two subgenera of ''Rhododendron''. They are distinguished from "true" rhododendrons by having only five anthers per flower. Species Description ''Rhododendron'' is a genus of shrubs and small to (rarely) large trees, the smallest species growing to tall ...
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Honey
Honey is a sweet and viscous substance made by several bees, the best-known of which are honey bees. Honey is made and stored to nourish bee colonies. Bees produce honey by gathering and then refining the sugary secretions of plants (primarily floral nectar) or the secretions of other insects, like the honeydew of aphids. This refinement takes place both within individual bees, through regurgitation and enzymatic activity, as well as during storage in the hive, through water evaporation that concentrates the honey's sugars until it is thick and viscous. Honey bees stockpile honey in the hive. Within the hive is a structure made from wax called honeycomb. The honeycomb is made up of hundreds or thousands of hexagonal cells, into which the bees regurgitate honey for storage. Other honey-producing species of bee store the substance in different structures, such as the pots made of wax and resin used by the stingless bee. Honey for human consumption is collected from w ...
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Kalmia
''Kalmia'' is a genus of about ten species of evergreen shrubs from 0.2–5 m tall, in the family Ericaceae. They are native to North America (mainly in the eastern half of the continent) and Cuba. They grow in acidic soils, with different species in wet acid bog habitats (''K. angustifolia, K. polifolia'') and dry, sandy soils (''K. ericoides, K. latifolia''). ''Kalmia'' was named by Linnaeus to honour his friend the botanist Pehr Kalm, who collected it in eastern North America during the mid-18th century. Earlier, Mark Catesby saw it during his travels in Carolina, and after his return to England in 1726, imported seeds. He described it, a costly rarity, in his ''Natural History of Carolina'', as ''Chamaedaphne foliis tini'', that is to say "with leaves like the Laurustinus"; the botanist and plant-collector Peter Collinson, who had begged some of the shrub from his correspondent John Custis in Virginia, wrote, when his plants flowered, that "I Really Think it exceeds the ...
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Asa Gray
Asa Gray (November 18, 1810 – January 30, 1888) is considered the most important American botanist of the 19th century. His ''Darwiniana'' was considered an important explanation of how religion and science were not necessarily mutually exclusive. Gray was adamant that a genetic connection must exist between all members of a species. He was also strongly opposed to the ideas of hybridization within one generation and special creation in the sense of its not allowing for evolution. He was a strong supporter of Darwin, although Gray's theistic evolution was guided by a Creator. As a professor of botany at Harvard University for several decades, Gray regularly visited, and corresponded with, many of the leading natural scientists of the era, including Charles Darwin, who held great regard for him. Gray made several trips to Europe to collaborate with leading European scientists of the era, as well as trips to the southern and western United States. He also built an extensive n ...
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Labrador Tea
Labrador tea is a common name for three closely related plant species in the genus ''Rhododendron'' as well as an herbal tea made from their leaves. All three species are primarily wetland plants in the heath family. The herbal tea has been a favorite beverage among Athabaskan First Nations and Inuit. Description All three species used to make Labrador tea are low, slow-growing shrubs with evergreen leaves: * ''Rhododendron tomentosum'' (northern Labrador tea, previously ''Ledum palustre''), * ''Rhododendron groenlandicum'', (bog Labrador tea, previously ''Ledum groenlandicum'' or ''Ledum latifolium'') and * ''Rhododendron neoglandulosum'', (western Labrador tea, or trapper's tea, previously ''Ledum glandulosum'' or ''Ledum columbianum''). The leaves are smooth on top with often wrinkled edges, and fuzzy white to red-brown underneath. ''R. tomentosum'', ''R. groenlandicum'', and ''R. neoglandulosum'' can be found in wetlands and peat bogs. Uses The Athabaskans and other ind ...
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Leucothoe (plant)
''Leucothoe'' is a genus of about 6 species of flowering plants in the family Ericaceae, native to Asia and the Americas. Many species have the common name doghobble. ''Leucothoe'' species contain grayanotoxins, a group of closely related neurotoxins named after ''Leucothoe grayana'', native to Japan. They are shrubs growing to 1–3 m tall, either deciduous or evergreen depending on species. The leaves are alternate, oblong-lanceolate, 2–15 cm long. The flowers are produced in racemes 3–15 cm long, each flower bell-shaped, 4–20 mm long, white or occasionally pink. ;Selected species *'' Leucothoe axillaris'' (coastal doghobble; southeastern United States) *'' Leucothoe davisiae'' (black laurel; Sierra Nevada, northern California & Oregon) *'' Leucothoe fontanesiana'' (highland doghobble or drooping leucothoe; southeastern United States) *''Leucothoe grayana'' (Japan) *'' Leucothoe griffithiana'' (eastern Himalaya, southwest China) *'' Leucothoe keiskei ...
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Agarista (plant)
''Agarista'' is a genus of plants in the family Ericaceae. ''Agarista'' species contain grayanotoxins, a group of closely related neurotoxins named after ''Leucothoe grayana'', native to Japan. Species * ''Agarista boliviensis'' - from South America, * ''Agarista buxifolia'' - from Réunion * ''Agarista eucalyptoides'' * ''Agarista populifolia'' (Lam.) Judd—Florida hobblebush * ''Agarista salicifolia'' - from Réunion There are also about 10 species endemic to Madagascar which are to be transferred to this genus from ''Agauria''. Plants of the World Online, accepts 32 species, as of January 2022. Taxonomy The genus name of ''Agarista'' is in honour of Agariste of Sicyon Agariste (; grc, Ἀγαρίστη) (fl. 6th century BC, around 560 BC) was the daughter, and possibly the heiress, of the tyrant of Sicyon, Cleisthenes. Her father wanted to marry her to the "best of the Hellenes" and organized a competition whose ... (fl. 6th century BC, around 560 BC). It was first des ...
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Nitrogen
Nitrogen is the chemical element with the symbol N and atomic number 7. Nitrogen is a nonmetal and the lightest member of group 15 of the periodic table, often called the pnictogens. It is a common element in the universe, estimated at seventh in total abundance in the Milky Way and the Solar System. At standard temperature and pressure, two atoms of the element bond to form N2, a colorless and odorless diatomic gas. N2 forms about 78% of Earth's atmosphere, making it the most abundant uncombined element. Nitrogen occurs in all organisms, primarily in amino acids (and thus proteins), in the nucleic acids ( DNA and RNA) and in the energy transfer molecule adenosine triphosphate. The human body contains about 3% nitrogen by mass, the fourth most abundant element in the body after oxygen, carbon, and hydrogen. The nitrogen cycle describes the movement of the element from the air, into the biosphere and organic compounds, then back into the atmosphere. Many indus ...
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Voltage Gated Sodium Channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel; also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel ( ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states. Even though the resting and inactive states would not allow the ions to flow through the channels the difference exists with respect to their structural conformation. Selectivity Sodium channels are highly selective for the transport of ions across cell memb ...
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