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Geographic Atrophy
Geographic atrophy (GA), also known as atrophic age-related macular degeneration (AMD) or advanced dry AMD, is an advanced form of age-related macular degeneration that can result in the progressive and irreversible loss of retinal tissue (photoreceptor cell, photoreceptors, retinal pigment epithelium, choriocapillaris) which can lead to a loss of central vision over time. It is estimated that GA affects over 5 million people worldwide and approximately 1 million patients in the US, which is similar to the prevalence of neovascular (wet) AMD, the other advanced form of the disease. The incidence of advanced AMD, both geographic atrophy and neovascular AMD, increases exponentially with age. Most current clinical trials aim to reduce the progression of GA lesion enlargement. Presentation Geographic atrophy is a chronic disease, which leads to visual function loss centrally. This often results in difficulties performing daily tasks such as reading, recognizing faces, and driving, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fundus Geographic Atrophy
''Fundus'' (Latin for "bottom") is an anatomical term referring to that part of a concavity in any Organ (biology), organ, which is at the far end from its opening. It may refer to: Anatomy * Fundus (brain), the deepest part of any sulcus of the cerebral cortex * Fundus (eye), the interior surface of the eye, opposite the lens, and including the retina, optic disc, macula and fovea, and posterior pole ** Fundus camera, equipment for photographing the interior of the eye ** Fundus photography * Fundus (stomach), the portion of the stomach which bulges up past the point of entry of the oesophagus * Fundus (uterus), the top portion, opposite from the cervix * Fundus of gallbladder, the portion of the gallbladder which lies the furthest from the cystic duct * Fundus of the urinary bladder Other uses * Fundus (seabed), the seabed in a tidal river below low water mark {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drusen
Drusen, from the German word for ''node'' or ''geode'' (singular, "Druse"), are tiny yellow or white accumulations of extracellular material that build up between Bruch's membrane and the retinal pigment epithelium of the eye. The presence of a few small ("hard") drusen is normal with advancing age, and most people over 40 have some hard drusen. However, the presence of larger and more numerous drusen in the macula is a common early sign of age-related macular degeneration (AMD). Classification Drusen associated with aging and macular degeneration are distinct from another clinical entity, optic disc drusen, which is present on the optic nerve head. Both age-related drusen and optic disc drusen can be observed by ophthalmoscopy. Optical coherence tomography scans of the orbits or head, calcification at the head of the optic nerve without change in size of globe strongly suggests drusen in a middle-age or elderly patient. Whether drusen promote AMD or are symptomatic of an und ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C). However, the agency also enforces other laws, notably Section 361 of the Public Health Service Act as well as associated regulations. Much of this regulatory-enforcement work is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avacincaptad Pegol
Avacincaptad pegol, sold under the brand name Izervay, is a medication used for the treatment of age-related macular degeneration. Avacincaptad pegol is a complement inhibitor. Avacincaptad pegol was approved for medical use in the United States in August 2023. Medical uses Avacincaptad pegol is indicated for the treatment of geographic atrophy Geographic atrophy (GA), also known as atrophic age-related macular degeneration (AMD) or advanced dry AMD, is an advanced form of age-related macular degeneration that can result in the progressive and irreversible loss of retinal tissue (photore ... secondary to age-related macular degeneration. Society and culture Avacincaptad pegol is the international nonproprietary name. References External links * * Complement system Ophthalmology drugs Nucleic acids {{Pharma-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pegcetacoplan
Pegcetacoplan, sold under the brand name Empaveli, among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria and geographic atrophy of the retina. Pegcetacoplan is a complement inhibitor. The most common side effects include injection-site reactions, infections, diarrhea, abdominal pain, respiratory tract infection, viral infection, and fatigue. Paroxysmal nocturnal hemoglobinuria is characterized by red blood cell destruction, anemia (red blood cells unable to carry enough oxygen to tissues), blood clots, and impaired bone marrow function (not making enough blood cells). Pegcetacoplan is the first treatment for paroxysmal nocturnal hemoglobinuria that binds to and inhibits complement protein C3. Pegcetacoplan was approved for medical use in the United States in May 2021. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication. In 2024, the American Society of Nephrology Annual Kidney Meeting, the study group who inv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
En Face
EN or En or en may refer to: Businesses * Bouygues (stock symbol EN) * Island Rail Corridor, formerly known as the Esquimalt and Nanaimo Railway (reporting mark EN) * Euronews, a news television and internet channel Language and writing * N, 14th letter of the Roman alphabet * EN, a mark in Sumerian cuneiform script for a High priest or Priestess (meaning "lord", or "priest") *En (digraph) /‹en›/, a phoneme *En (Cyrillic), 15th letter of the Cyrillic alphabet *En (typography), a unit of typographical width ** Dash#En dash /en dash/, a dash of length 1 en * En language, a language spoken in northern Vietnam *English language (ISO language code: en) Organisations * Eastern National, a US organization providing educational products to National Park visitors * English Nature, a former UK government conservation agency * Envirolink Northwest, an environmental organization in England Religion * En (deity) in Albanian mythology Science and technology * Engineer * E''n'' (Lie a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autofluorescence
Autofluorescence is the natural fluorescence of biological structures such as mitochondria and lysosomes, in contrast to fluorescence originating from artificially added fluorescent markers (fluorophores). The most commonly observed autofluorescencing molecules are NADPH and flavin group, flavins; the extracellular matrix can also contribute to autofluorescence because of the intrinsic properties of collagen and elastin. Generally, proteins containing an increased amount of the amino acids tryptophan, tyrosine, and phenylalanine show some degree of autofluorescence. Autofluorescence also occurs in non-biological materials found in many papers and textiles. Autofluorescence from U.S. paper money has been demonstrated as a means for discerning counterfeit currency from authentic currency. Microscopy Autofluorescence can be problematic in fluorescence microscopy. Light-emitting staining, stains (such as fluorescently labelled antibody, antibodies) are applied to Sample (material ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fundus (eye)
The fundus of the eye is the interior surface of the eye opposite the lens and includes the retina, optic disc, macula, fovea, and posterior pole.Cassin, B. and Solomon, S. ''Dictionary of Eye Terminology''. Gainesville, Florida: Triad Publishing Company, 1990. The fundus can be examined by ophthalmoscopy and/or fundus photography. Variation The color of the fundus varies both between and within species. In one study of primates the retina is blue, green, yellow, orange, and red; only the human fundus (from a lightly pigmented blond person) is red. The major differences noted among the "higher" primate species were size and regularity of the border of macular area, size and shape of the optic disc, apparent 'texturing' of retina, and pigmentation of retina. Clinical significance Medical signs that can be detected from observation of eye fundus (generally by funduscopy) include hemorrhages, exudates, cotton wool spots, blood vessel abnormalities ( tortuosity, puls ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heat Map
A heat map (or heatmap) is a 2-dimensional data visualization technique that represents the magnitude of individual values within a dataset as a color. The variation in color may be by hue or intensity. In some applications such as crime analytics or website click-tracking, color is used to represent the ''density'' of data points rather than a value associated with each point. "Heat map" is a relatively new term, but the practice of shading matrices has existed for over a century. History Heat maps originated in 2D displays of the values in a data matrix. Larger values were represented by small dark gray or black squares (pixels) and smaller values by lighter squares. The earliest known example dates to 1873, when Toussaint Loua used a hand-drawn and colored shaded matrix to visualize social statistics across the districts of Paris. The idea of reordering rows and columns to reveal structure in a data matrix, known as seriation, was introduced by Flinders Petrie in 1899. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferroptosis
Ferroptosis (also known as oxytosis) is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides. Ferroptosis is biochemically, genetically, and morphologically distinct from other forms of regulated cell death such as apoptosis and necroptosis. Oxytosis/ferroptosis can be initiated by the failure of the glutathione-dependent antioxidant defenses, resulting in unchecked lipid peroxidation and eventual cell death. Lipophilic antioxidants and iron chelators can prevent ferroptotic cell death. Researchers have identified roles in which oxytosis/ferroptosis can contribute to the medical field, such as the development of cancer therapies. Ferroptosis activation plays a regulatory role on growth of tumor cells in the human body. However, the positive effects of oxytosis/ferroptosis could be potentially neutralized by its disruption of metabolic pathways and disruption of homeostasis in the human body. Since oxytosis/ferroptosis is a form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid Peroxidation
Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, resulting in the formation of peroxide and hydroperoxide derivatives.{{Cite journal , last1=Ayala , first1=Antonio , last2=Muñoz , first2=Mario F. , last3=Argüelles , first3=Sandro , date=2014 , title=Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal , journal=Oxidative Medicine and Cellular Longevity , language=en , volume=2014 , pages=1–31 , doi=10.1155/2014/360438 , doi-access=free , issn=1942-0900 , pmc=4066722 , pmid=24999379 It occurs when free radicals, specifically reactive oxygen species (ROS), interact with lipids within cell membranes, typically polyunsaturated fatty acids (PUFAs) as they have carbon–carbon double bonds. This reaction leads to the formation of lipid radicals, collectively referred to as lipid peroxides or lipid oxidation products (LOPs), which in turn react with other ox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iron
Iron is a chemical element; it has symbol Fe () and atomic number 26. It is a metal that belongs to the first transition series and group 8 of the periodic table. It is, by mass, the most common element on Earth, forming much of Earth's outer and inner core. It is the fourth most abundant element in the Earth's crust, being mainly deposited by meteorites in its metallic state. Extracting usable metal from iron ores requires kilns or furnaces capable of reaching , about 500 °C (900 °F) higher than that required to smelt copper. Humans started to master that process in Eurasia during the 2nd millennium BC and the use of iron tools and weapons began to displace copper alloys – in some regions, only around 1200 BC. That event is considered the transition from the Bronze Age to the Iron Age. In the modern world, iron alloys, such as steel, stainless steel, cast iron and special steels, are by far the most common industrial metals, due to their mechan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
