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Fecal Microbiota Transplant
Fecal microbiota transplant (FMT), also known as a stool transplant, is the process of transferring fecal bacteria and other microbes from a healthy individual into another individual. FMT is an effective treatment for Clostridioides difficile infection, ''Clostridioides difficile'' infection (CDI). For recurrent CDI, FMT is more effective than vancomycin alone, and may improve the outcome after the first index infection. Side effects include a risk of infections; therefore, donors should be Screening (medicine), screened for pathogens. With CDI becoming more common, FMT is gaining prominence. Some experts call for it to become the first-line therapy for CDI. FMT has been used experimentally to treat other gastrointestinal diseases, including colitis, constipation, irritable bowel syndrome, and Neurology, neurological conditions, such as multiple sclerosis and Parkinson's. In the United States, human feces have been regulated as an experimental drug since 2013. In the Unite ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escherichia Coli
''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Escherichia'' that is commonly found in the lower intestine of warm-blooded organisms. Most ''E. coli'' strains are part of the normal microbiota of the gut, where they constitute about 0.1%, along with other facultative anaerobes. These bacteria are mostly harmless or even beneficial to humans. For example, some strains of ''E. coli'' benefit their hosts by producing vitamin K2 or by preventing the colonization of the intestine by harmful pathogenic bacteria. These mutually beneficial relationships between ''E. coli'' and humans are a type of mutualistic biological relationship—where both the humans and the ''E. coli'' are benefitting each other. ''E. coli'' is expelled into the environment within fecal matter. The bacterium grows massi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic Resistance
Antimicrobial resistance (AMR or AR) occurs when microbes evolve mechanisms that protect them from antimicrobials, which are drugs used to treat infections. This resistance affects all classes of microbes, including bacteria (antibiotic resistance), viruses (antiviral resistance), parasites (antiparasitic resistance), and fungi (antifungal resistance). Together, these adaptations fall under the AMR umbrella, posing significant challenges to healthcare worldwide. Misuse and improper management of antimicrobials are primary drivers of this resistance, though it can also occur naturally through genetic mutations and the spread of resistant genes. Antibiotic resistance, a significant AMR subset, enables bacteria to survive antibiotic treatment, complicating infection management and treatment options. Resistance arises through spontaneous mutation, horizontal gene transfer, and increased selective pressure from antibiotic overuse, both in medicine and agriculture, which accelerat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shanghai
Shanghai, Shanghainese: , Standard Chinese pronunciation: is a direct-administered municipality and the most populous urban area in China. The city is located on the Chinese shoreline on the southern estuary of the Yangtze River, with the Huangpu River flowing through it. The population of the city proper is the List of largest cities, second largest in the world after Chongqing, with around 24.87 million inhabitants in 2023, while the urban area is the List of cities in China by population, most populous in China, with 29.87 million residents. As of 2022, the Greater Shanghai metropolitan area was estimated to produce a gross metropolitan product (GDP (nominal), nominal) of nearly 13 trillion Renminbi, RMB ($1.9 trillion). Shanghai is one of the world's major centers for finance, #Economy, business and economics, research, science and technology, manufacturing, transportation, List of tourist attractions in Shanghai, tourism, and Culture of Shanghai, culture. The Port of Sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autism
Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing differences, focused interests, and repetitive behaviors, which may include stimming. Formal diagnosis requires significant challenges in multiple domains of life, with characteristics that are atypical or more pronounced than expected for one's age and sociocultural context.(World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624 Motor coordination difficulties are common but not required for diagnosis. Autism is a spectrum disorder, resulting in wide variations in presentation and support needs, such as that between speaking and non-speaking populations. Increased estimates of autism prevalence since the 1990s are primarily attributed to broader c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CBC News
CBC News is the division of the Canadian Broadcasting Corporation responsible for the news gathering and production of news programs on the corporation's English-language operations, namely CBC Television, CBC Radio, CBC News Network, and CBC.ca. Founded in 1941 by the public broadcaster, CBC News is the largest news broadcaster in Canada and has local, regional, and national broadcasts and stations. It frequently collaborates with its organizationally separate French-language counterpart, Radio-Canada Info. History The first CBC newscast was a bilingual radio report on November 2, 1936. The CBC News Service was inaugurated during World War II on January 1, 1941, when Dan McArthur, chief news editor, had Wells Ritchie prepare for the announcer Charles Jennings a national report at 8:00 pm. Previously, CBC relied on The Canadian Press to provide it with wire copy for its news bulletins. Readers who followed Jennings were Lorne Greene, Frank Herbert and Earl Cameron. '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naturopathy
Naturopathy, or naturopathic medicine, is a form of alternative medicine. A wide array of practices branded as "natural", "non-invasive", or promoting "self-healing" are employed by its practitioners, who are known as naturopaths. Difficult to generalize, these treatments range from the Pseudoscience, pseudoscientific and thoroughly discredited, like homeopathy, to the widely accepted, like certain forms of psychotherapy. The ideology and methods of naturopathy are based on vitalism and folk medicine rather than evidence-based medicine, although practitioners may use techniques supported by evidence. The ethics of naturopathy have been called into question by medical professionals and its practice has been characterized as quackery. Naturopathic practitioners commonly encourage alternative treatments that are rejected by conventional medicine, including resistance to surgery or vaccines for some patients. The diagnoses made by naturopaths often have no basis in science and ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-PD-1 Immunotherapy
Programmed cell death protein 1 (PD-1), (CD279 cluster of differentiation 279). PD-1 is a protein encoded in humans by the ''PDCD1'' gene. PD-1 is a cell surface receptor on T cells and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-1 inhibitors, a new class of drugs that block PD-1, activate the immune system to attack tumors and are used to treat certain types of cancer. PD-1 is a cell surface receptor that belongs to the immunoglobulin superf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ulcerative Colitis
Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease. It is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood ( hematochezia). Weight loss, fever, and anemia may also occur. Often, symptoms come on slowly and can range from mild to severe. Symptoms typically occur intermittently with periods of no symptoms between flares. Complications may include abnormal dilation of the colon ( megacolon), inflammation of the eye, joints, or liver, and colon cancer. The cause of UC is unknown. Theories involve immune system dysfunction, genetics, changes in the normal gut bacteria, and environmental factors. Rates tend to be higher in the developed world with some proposing this to be the result of less exposure to intestinal infections, or to a Western diet and lifestyle. The remova ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
By Mouth
Oral administration is a route of administration whereby a substance is taken through the Human mouth, mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administration can be easier and less painful than other routes of administration, such as Injection (medicine), injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth". The expression is used in medicine to describe a treatment that is taken orally (but not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fecal Microbiota Spores, Live
Live fecal microbiota spores, sold under the brand name Vowst, are a fecal microbiota product used to prevent the recurrence of ''Clostridioides difficile'' infection (''C. difficile''). Live fecal microbiota spores contain live bacteria and are manufactured from human fecal matter donated by qualified individuals. Vowst was approved for medical use in the United States in April 2023. It is the first fecal microbiota product that is taken by mouth (orally). Medical uses Fecal microbiota spores (live) are indicated to prevent the recurrence of ''Clostridioides difficile'' infection (CDI) in individuals 18 years of age and older following antibacterial treatment for recurrent CDI (rCDI). History The safety of fecal microbiota spores (live) was evaluated in a randomized, double-blind, placebo-controlled clinical study and an open-label clinical study conducted in the US and Canada. The participants who suffered from recurrent ''C. difficile'' infection were subjected to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fecal Microbiota, Live
Fecal microbiota, sold under the brand name, Rebyota is used for the prevention of recurrence of ''Clostridioides difficile'' infection. The most commonly reported adverse reactions include abdominal pain, diarrhea, abdominal distention, flatulence, and nausea. Fecal microbiota is prepared from stool donated by qualified individuals. The donors and the donated stool are tested for a panel of transmissible pathogens. Fecal microbiota is the first fecal microbiota product approved by the US Food and Drug Administration (FDA). Fecal microbiota was approved for medical use in the United States in November 2022. Medical uses Fecal microbiota is approved for the prevention of recurrence of ''Clostridioides difficile'' infection (CDI) in people 18 years of age and older. It is for use after an individual has completed antibiotic treatment for recurrent CDI. History The safety of fecal microbiota was assessed from two randomized, double-blind, placebo-controlled clinical studie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First-line Treatment
A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis. Both words, ''treatment'' and ''therapy'', are often abbreviated tx, Tx, or Tx. As a rule, each therapy has indications and contraindications. There are many different types of therapy. Not all therapies are effective. Many therapies can produce unwanted adverse effects. ''Treatment'' and ''therapy'' are often synonymous, especially in the usage of health professionals. However, in the context of mental health, the term ''therapy'' may refer specifically to psychotherapy. Semantic field The words ''care'', ''therapy'', ''treatment'', and ''intervention'' overlap in a semantic field, and thus they can be synonymous depending on context. Moving rightward through that order, the connotative level of holism decreases and the level of specificity (to concrete instances) increases. Thus, in health-care contexts (where its senses are always noncount), th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
