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Cowper's Fluid
Pre-ejaculate (also known as pre-ejaculatory fluid, pre-seminal fluid or Cowper's fluid, and colloquially as pre-cum) is a clear, colorless, viscous fluid that is emitted from the urethra of the penis during sexual arousal and in general during sexual activity. It is similar in composition to semen but has distinct chemical differences. The presence of sperm in the fluid varies from low to absent. Pre-ejaculate functions as a lubricant and an acid neutralizer. Origin and composition The fluid is discharged from the urethra of the penis during arousal, masturbation, foreplay or at an early stage during sexual intercourse, some time before the individual fully reaches orgasm and semen is ejaculated. It is primarily produced by the bulbourethral glands (Cowper's glands), with the glands of Littré (the mucus-secreting urethral glands) also contributing. The amount of fluid that is issued varies widely among individuals. Some individuals do not produce any pre-ejaculate fluid, ...
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Bulbourethral Gland
The bulbourethral glands or Cowper's glands (named for English anatomist William Cowper) are two small exocrine and accessory glands in the reproductive system of many male mammals. They are homologous to Bartholin's glands in females. The bulbourethral glands are responsible for producing a pre-ejaculate fluid called Cowper's fluid (known colloquially as ''pre-cum''), which is secreted during sexual arousal, neutralizing the acidity of the urethra in preparation for the passage of sperm cells. The paired glands are found adjacent to the urethra just below the prostate, seen best by screening (medicine) MRI as a tool in preventative healthcare in males. Screening MRI may be performed when there is a positive prostate-specific antigen on basic laboratory tests. Prostate cancer is the second-most common cause of cancer-related mortality in males in the USA. Most species of placental mammals have bulbourethral glands, but they are absent in Caniformia and Cetacea. They are th ...
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Finasteride
Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used to treat pattern hair loss and benign prostatic hyperplasia (BPH) in men. It can also be used to treat hirsutism, excessive hair growth in women. It is usually taken oral administration, orally but there are Topical medication, topical formulations for patients with hair loss, designed to minimize systemic exposure by acting specifically on hair follicles. Finasteride is a 5α-reductase inhibitor and therefore an antiandrogen. It works by enzyme inhibitor, decreasing the biosynthesis, production of dihydrotestosterone (DHT) by about 70%. In addition to DHT, finasteride also inhibits the production of several anticonvulsant neurosteroids including allopregnanolone, androstanediol, and tetrahydrodeoxycorticosterone. Adverse effects from finasteride are rare in men with already enlarged prostates; however, some men experience sexual dysfunction, depression (mood), depression, and gyne ...
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Coitus Interruptus
''Coitus interruptus'', also known as withdrawal, pulling out or the pull-out method, is an act of birth control during sexual intercourse, whereby the penis is withdrawn from a vagina prior to ejaculation so that the ejaculate (semen) may be directed away in an effort to avoid insemination., which cites: : Population Action International (1991). "A Guide to Methods of Birth Control." Briefing Paper No. 25, Washington, D. C. This method was used by an estimated 38 million couples worldwide in 1991. ''Coitus interruptus'' does not protect against sexually transmitted infections (STIs). History Perhaps the oldest description of the use of the withdrawal method to avoid pregnancy is the story of Onan in the Torah and the Bible. This text is believed to have been written over 2,500 years ago. Societies in the ancient civilizations of Greece and Rome preferred small families and are known to have practiced a variety of birth control methods. There are references that have led hi ...
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Masters And Johnson
The Masters and Johnson research team, composed of William H. Masters (1915–2001) and Virginia E. Johnson (1925–2013), pioneered research into the nature of human sexual response and the diagnosis and treatment of sexual disorders and dysfunctions from 1957 until the 1990s. The work of Masters and Johnson began in the Department of Obstetrics and Gynecology at Washington University in St. Louis and was continued at the independent not-for-profit research institution they founded in St. Louis in 1964, originally called the Reproductive Biology Research Foundation and renamed the Masters and Johnson Institute in 1978. In the initial phase of Masters and Johnson's studies, from 1957 until 1965, they recorded some of the first laboratory data on the anatomy and physiology of human sexual response based on direct observation of 382 women and 312 men in what they conservatively estimated to be "10,000 complete cycles of sexual response". Their findings, particularly on the n ...
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Sexual Activity
Human sexual activity, human sexual practice or human sexual behaviour is the manner in which humans experience and express their sexuality. People engage in a variety of sexual acts, ranging from activities done alone (e.g., masturbation) to acts with another person (e.g., sexual intercourse, non-penetrative sex, oral sex, etc.) or persons (e.g., orgy) in varying patterns of frequency, for a wide variety of reasons. Sexual activity usually results in sexual arousal and physiological changes in the aroused person, some of which are pronounced while others are more subtle. Sexual activity may also include conduct and activities which are intended to arouse the sexual interest of another or enhance the sex life of another, such as strategies to find or attract partners ( courtship and display behaviour), or personal interactions between individuals (for instance, foreplay or BDSM). Sexual activity may follow sexual arousal. Human sexual activity has sociological, cognitive, ...
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Vagina
In mammals and other animals, the vagina (: vaginas or vaginae) is the elastic, muscular sex organ, reproductive organ of the female genital tract. In humans, it extends from the vulval vestibule to the cervix (neck of the uterus). The #Vaginal opening and hymen, vaginal introitus is normally partly covered by a thin layer of mucous membrane, mucosal tissue called the hymen. The vagina allows for Copulation (zoology), copulation and birth. It also channels Menstruation (mammal), menstrual flow, which occurs in humans and closely related primates as part of the menstrual cycle. To accommodate smoother penetration of the vagina during sexual intercourse or other sexual activity, vaginal moisture increases during sexual arousal in human females and other female mammals. This increase in moisture provides vaginal lubrication, which reduces friction. The texture of the vaginal walls creates friction for the penis during sexual intercourse and stimulates it toward ejaculation, en ...
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Urine
Urine is a liquid by-product of metabolism in humans and many other animals. In placental mammals, urine flows from the Kidney (vertebrates), kidneys through the ureters to the urinary bladder and exits the urethra through the penile meatus (males) or urethral meatus of the vulva (females) during urination. In other vertebrates, urine is excreted through the cloaca. Urine contains water-soluble by-products of Cell (biology), cellular metabolism that are rich in nitrogen and must be clearance (medicine), cleared from the Circulatory system, bloodstream, such as urea, uric acid and creatinine. A urinalysis can detect nitrogenous wastes of the mammalian body. Urine plays an important role in the earth's nitrogen cycle. In balanced ecosystems, urine fertilizes the soil and thus helps plants to grow. Therefore, Reuse of excreta, urine can be used as a fertilizer. Some animals use it to territory (animal)#Scent marking, mark their territories. Historically, aged or fermented urine (kn ...
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Gamma-glutamyltransferase
Gamma-glutamyltransferase (also γ-glutamyltransferase, GGT, gamma-GT, gamma-glutamyl transpeptidase; ) is a transferase (a type of enzyme) that catalyzes the transfer of gamma- glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification. Other lines of evidence indicate that GGT can also exert a pro-oxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology. This transferase is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker. Nomenclature The name γ-glutamyltransferase is preferred by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. The Expert Panel on Enzymes o ...
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Acid Phosphatase
Acid phosphatase (EC 3.1.3.2, systematic name ''phosphate-monoester phosphohydrolase (acid optimum)'') is an enzyme that frees attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphoric monoester hydrolases, phosphomonoesterase. It is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum. This enzyme is present in many animal and plant species. Different forms of acid phosphatase are found in different Organ (anatomy), organs, and their blood plasma, serum levels are used to evaluate the success of the surgical treatment of prostate cancer. In the past, they were also used to diagnose this type of cancer. It is also used as a cytogenetic marker to distinguish the two different lineages of acute lymphoblastic leukemia (ALL) : B-ALL (a leukemia of B lymphocytes) is acid-phosphatase negative, T-ALL (originating instead from T Lymphocytes) is ...
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American Society For Reproductive Medicine
The American Society for Reproductive Medicine (ASRM) is a nonprofit, multidisciplinary organization for advancement of the science and practice of reproductive medicine. The society has its headquarters in Washington, D.C., and its administrative office in Birmingham, Alabama. An associated special interest group, the Society for Assisted Reproductive Technology (SART), maintains a national registry for tracking IVF attempts and outcomes. History and activities Founded in 1944 by a small group of fertility experts who met in Chicago, the initial name was the American Society for the Study of Sterility, changed in 1965 to American Fertility Society (AFS). The current name, American Society for Reproductive Medicine, was adopted in 1994. In 2018, ASRM created its own research institute. In 2019, it moved its headquarters to Washington, D.C., from Birmingham, Alabama. Though primarily an American organization, it had members from over 100 countries as of 2020. The society hosts ...
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