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Biometrician
Biostatistics (also known as biometry) are the development and application of statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results. History Biostatistics and genetics Biostatistical modeling forms an important part of numerous modern biological theories. Genetics studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even contributed with statistical advances with the development of methods and tools. Gregor Mendel started the genetics studies investigating genetics segregation patterns in families of peas and used statistics to explain the collected data. In the early 1900s, after the rediscovery of Mendel's Mendelian inheritance work, there were gaps in understanding between genetics and evolutionary Darwinism. Francis Galton tried to expand Mendel's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karl Pearson
Karl Pearson (; born Carl Pearson; 27 March 1857 – 27 April 1936) was an English mathematician and biostatistician. He has been credited with establishing the discipline of mathematical statistics. He founded the world's first university statistics department at University College, London in 1911, and contributed significantly to the field of biometrics and meteorology. Pearson was also a proponent of social Darwinism, eugenics and scientific racism. Pearson was a protégé and biographer of Sir Francis Galton. He edited and completed both William Kingdon Clifford's ''Common Sense of the Exact Sciences'' (1885) and Isaac Todhunter's ''History of the Theory of Elasticity'', Vol. 1 (1886–1893) and Vol. 2 (1893), following their deaths. Biography Pearson was born in Islington, London into a Quaker family. His father was William Pearson QC of the Inner Temple, and his mother Fanny (née Smith), and he had two siblings, Arthur and Amy. Pearson attended University College Scho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modern Synthesis (20th Century)
The modern synthesis was the early 20th-century synthesis of Charles Darwin's theory of evolution and Gregor Mendel's ideas on heredity into a joint mathematical framework. Julian Huxley coined the term in his 1942 book, ''Evolution: The Modern Synthesis''. The synthesis combined the ideas of natural selection, Mendelian inheritance, Mendelian genetics, and population genetics. It also related the broad-scale macroevolution seen by paleontology, palaeontologists to the small-scale microevolution of local population, populations. The synthesis was defined differently by its founders, with Ernst Mayr in 1959, G. Ledyard Stebbins in 1966, and Theodosius Dobzhansky in 1974 offering differing basic postulates, though they all include natural selection, working on heritable variation supplied by mutation. Other major figures in the synthesis included E. B. Ford, Bernhard Rensch, Ivan Schmalhausen, and George Gaylord Simpson. An early event in the modern synthesis was R. A. Fisher's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gregor Mendel
Gregor Johann Mendel, Augustinians, OSA (; cs, Řehoř Jan Mendel; 20 July 1822 – 6 January 1884) was a biologist, meteorologist, mathematician, Augustinians, Augustinian friar and abbot of St Thomas's Abbey, Brno, St. Thomas' Abbey in Brünn (''Brno''), Margraviate of Moravia. Mendel was born in a Sudeten Germans, German-speaking family in the Austrian Silesia, Silesian part of the Austrian Empire (today's Czech Republic) and gained posthumous recognition as the founder of the modern science of genetics. Though farmers had known for millennia that crossbreeding of animals and plants could favor certain desirable trait (biological), traits, Mendel's pea plant experiments conducted between 1856 and 1863 established many of the rules of biological inheritance, heredity, now referred to as the laws of Mendelian inheritance. Mendel worked with seven characteristics of pea plants: plant height, pod shape and color, seed shape and color, and flower position and color. Taking seed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Raphael Weldon
Walter Frank Raphael Weldon Fellow of the Royal Society, FRS (15 March 1860 – 13 April 1906), was an English evolutionary biologist and a founder of biometry. He was the joint founding editor of ''Biometrika'', with Francis Galton and Karl Pearson. Family Weldon was the second child of the journalist and industrial chemist, Walter Weldon, and his wife Anne Cotton. On 13 March 1883, Weldon married Florence Tebb, daughter of the social reformer William Tebb. Life and education Medicine was his intended career and he spent the academic year 1876-1877 at University College London. Among his teachers were the zoologist E. Ray Lankester and the mathematician Olaus Henrici. In the following year he transferred to King's College London and then to St John's College, Cambridge in 1878. There Weldon studied with the developmental morphologist Francis Maitland Balfour, Francis Balfour who influenced him greatly; Weldon gave up his plans for a career in medicine. In 1881 he gained a fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francis Galton
Sir Francis Galton, FRS FRAI (; 16 February 1822 – 17 January 1911), was an English Victorian era polymath: a statistician, sociologist, psychologist, anthropologist, tropical explorer, geographer, inventor, meteorologist, proto-geneticist, psychometrician and a proponent of social Darwinism, eugenics, and scientific racism. He was knighted in 1909. Galton produced over 340 papers and books. He also created the statistical concept of correlation and widely promoted regression toward the mean. He was the first to apply statistical methods to the study of human differences and inheritance of intelligence, and introduced the use of questionnaires and surveys for collecting data on human communities, which he needed for genealogical and biographical works and for his anthropometric studies. He was a pioneer of eugenics, coining the term itself in 1883, and also coined the phrase " nature versus nurture". His book ''Hereditary Genius'' (1869) was the first social sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Bateson
William Bateson (8 August 1861 – 8 February 1926) was an English biologist who was the first person to use the term genetics to describe the study of heredity, and the chief populariser of the ideas of Gregor Mendel following their rediscovery in 1900 by Hugo de Vries and Carl Correns. His 1894 book ''Materials for the Study of Variation'' was one of the earliest formulations of the new approach to genetics. Early life and education Bateson was born 1861 in Whitby on the Yorkshire coast, the son of William Henry Bateson, Master of St John's College, Cambridge. He was educated at Rugby School and at St John's College, where he graduated BA in 1883 with a first in natural sciences. Taking up embryology, he went to the United States to investigate the development of ''Balanoglossus'', a worm-like hemichordate which led to his interest in vertebrate origins. In 1883–4 he worked in the laboratory of William Keith Brooks, at the Chesapeake Zoölogical Laboratory in Hampton, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Population Genetics
Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and population structure. Population genetics was a vital ingredient in the emergence of the modern evolutionary synthesis. Its primary founders were Sewall Wright, J. B. S. Haldane and Ronald Fisher, who also laid the foundations for the related discipline of quantitative genetics. Traditionally a highly mathematical discipline, modern population genetics encompasses theoretical, laboratory, and field work. Population genetic models are used both for statistical inference from DNA sequence data and for proof/disproof of concept. What sets population genetics apart from newer, more phenotypic approaches to modelling evolution, such as evolutionary game theory and adaptive dynamics, is its emphasis on such genetic phenomena as dominance, epi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
F-statistics
In population genetics, ''F''-statistics (also known as fixation indices) describe the statistically expected level of heterozygosity in a population; more specifically the expected degree of (usually) a reduction in heterozygosity when compared to Hardy–Weinberg expectation. ''F''-statistics can also be thought of as a measure of the correlation between genes drawn at different levels of a (hierarchically) subdivided population. This correlation is influenced by several evolutionary processes, such as genetic drift, founder effect, bottleneck, genetic hitchhiking, meiotic drive, mutation, gene flow, inbreeding, natural selection, or the Wahlund effect, but it was originally designed to measure the amount of allelic fixation owing to genetic drift. The concept of ''F''-statistics was developed during the 1920s by the American geneticist Sewall Wright, who was interested in inbreeding in cattle. However, because complete dominance causes the phenotypes of homozygote dominants ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inbreeding Coefficient
The coefficient of inbreeding of an individual is the probability that two alleles at any locus in an individual are identical by descent from the common ancestor(s) of the two parents. The coefficient of inbreeding is: The probability that two alleles at a given locus are identical by descent. The coefficient of relationship is: The proportion Proportionality, proportion or proportional may refer to: Mathematics * Proportionality (mathematics), the property of two variables being in a multiplicative relation to a constant * Ratio, of one quantity to another, especially of a part compare ... of genes that are held in common by two individuals as a result of direct or collateral relationship. References Population genetics {{genetics-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primordial Soup
Primordial soup, also known as, primordial goo, primordial ooze, prebiotic soup and prebiotic broth, is the hypothetical set of conditions present on the Earth around 3.7 to 4.0 billion years ago. It is an aspect of the heterotrophic theory (also known as the Oparin–Haldane hypothesis) concerning the origin of life, first proposed by Alexander Oparin in 1924, and J. B. S. Haldane in 1929. As formulated by Oparin, in the primitive Earth's surface layers, carbon, hydrogen, water vapour, and ammonia reacted to form the first organic compounds. The concept of a primordial soup gained credence in 1953 when the "Miller–Urey experiment" used a highly reduced mixture of gases—methane, ammonia and hydrogen—to form basic organic monomers, such as amino acids. Historical background The notion that living beings originated from inanimate materials comes from the Ancient Greeks—the theory known as spontaneous generation. Aristotle in the 4th century BCE gave a proper explanation, wri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mathematical Biology
Mathematical and theoretical biology, or biomathematics, is a branch of biology which employs theoretical analysis, mathematical models and abstractions of the living organisms to investigate the principles that govern the structure, development and behavior of the systems, as opposed to experimental biology which deals with the conduction of experiments to prove and validate the scientific theories. The field is sometimes called mathematical biology or biomathematics to stress the mathematical side, or theoretical biology to stress the biological side. Theoretical biology focuses more on the development of theoretical principles for biology while mathematical biology focuses on the use of mathematical tools to study biological systems, even though the two terms are sometimes interchanged. Mathematical biology aims at the mathematical representation and modeling of biological processes, using techniques and tools of applied mathematics. It can be useful in both theoretical and prac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical
Statistics (from German: ''Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample to the population as a whole. An experim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
