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Atypical SLCs
Atypical Solute Carrier Families (Atypical SLCs) are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families. Atypical major facilitator superfamily transport families Most atypical SLCs are families within the major facilitator superfamily (MFS). These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers. They are, however, not named according to the SLC root system, or classified into any of the existing SLC families. Atypical MFS transporter families (ATMFs) are categorised based on their sequence similarity and phylogenetic closeness. Some Atypical SLC of MFS type are: OCA2, CLN3, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solute Carrier Family
The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB, TCDB database. Solutes that are transported by the various SLC group members are extremely diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas Ammonia transporter, ammonia. As is typical of integral membrane proteins, SLCs contain a number of hydrophobic transmembrane Alpha helix, alpha helices connected to each other by hydrophilic intra- and extra-cellular loops. Depending on the SLC, these transporters are functional as either monomers or obligate homo- or hetero-oligomers. Many SLC fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Facilitator Superfamily
The major facilitator superfamily (MFS) is a Protein superfamily, superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmosis, chemiosmotic gradients. Function The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the import or export of target substrates. The MFS family was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drugs, metabolites, oligosaccharides, amino acids and oxyanions were all transported by MFS family members. These proteins energetically drive transport utilizing the electrochemical gradient of the target substrate (uniporter), or act as a cotransporter where transport is coupled to the movement of a second substrate. Fold The basic fold of the MFS transporter is built around 12, or in some cases, 14 transmembrane helix, transmembrane helices (TMH), with two 6- (o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNC93B1
Unc-93 homolog B1 ('' C. elegans''), also known as UNC93B1, is a protein which in humans is encoded by the ''UNC93B1'' gene. Function This gene encodes a protein with similarity to the ''Caenorhabditis elegans ''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a Hybrid word, blend of the Greek ''caeno-'' (recent), ''r ...'' unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. References Further reading * * * * * * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNC93A
Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene. Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans. It belongs to the atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein. UNC93A is closely related to UNC93B1 Unc-93 homolog B1 ('' C. elegans''), also known as UNC93B1, is a protein which in humans is encoded by the ''UNC93B1'' gene. Function This gene encodes a protein with similarity to the ''Caenorhabditis elegans ''Caenorhabditis elegans'' ( ... and MFSD11. UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in ''in vivo'' samples. It is expressed in neurons, with staining close to the plasma membrane. Read also for functional studies in C.elegans. For you who are interested to read more about Unc93A in different species, see: References Further reading * Human proteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd14b
Major facilitator superfamily The major facilitator superfamily (MFS) is a Protein superfamily, superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmosis, chemiosmotic gradients. Function The major ... domain containing 14B (MFSD14B, HIATL1) is an atypical solute carrier of MFS type. It locates to intracellular membranes. HGNC:23376 TCDB: 2.A.1.2.30 MFSD14B cluster to AMTF1, together with MFSD9, MFSD10 and MFSD14A. References {{Reflist Solute carrier family Transmembrane proteins Transport proteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Facilitator Superfamily Domain Containing 14a
Major facilitator superfamily domain containing 14A (MFSD14A, HIAT1) is a protein that in humans is encoded by the MFSD14A gene. MFSD14A is an atypical solute carrier of MFS type. HGNC:23363 MFSD14A cluster to AMTF1, together with MFSD9, MFSD10 and MFSD14B Major facilitator superfamily The major facilitator superfamily (MFS) is a Protein superfamily, superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmosis, chemiosmotic gr .... References {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd11
Major facilitator superfamily The major facilitator superfamily (MFS) is a Protein superfamily, superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmosis, chemiosmotic gradients. Function The major ... domain containing 11 (MFSD11) is an atypical Solute carrier found in plasma membranes. HGNC ID:25458 TCDB: 2.A.1.58.3 MFSD11 cluster to AMTF10. References Solute carrier family {{gene-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MFSD9
Major facilitator superfamily domain-containing protein 9 is a protein that in humans is encoded by the MFSD9 gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... It is a potential solute carrier, and called atypical solute carrier since it is not named according to the SLC nomenclature. It is expressed both in central and peripheral organs. References Transport proteins {{Protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MFSD8
Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the ''MFSD8'' gene. MFSD8 is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 ( AMTF2). Function MFSD8 is a ubiquitous integral membrane protein which contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein, likely localizes to lysosomal membranes. Clinical significance Mutations in the MFSD8 gene have been of neuronal ceroid lipofuscinosis Neuronal ceroid lipofuscinosis is a family of at least eight genetically separate neurodegenerative lysosomal storage diseases that result from excessive accumulation of lipopigments (lipofuscin) in the body's tissues. These lipopigments are made .... References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd3
Major facilitator superfamily domain containing 3 (MFSD3) is a protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ... belonging to the MFS Pfam clan. It is an Atypical solute carrier located to the neuronal plasma membrane. HGNC:25157 TCDB: 2.A.1.25.4 MFSD3 belongs to AMTF15. References Solute carrier family {{gene-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Family
A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes a corresponding protein with a 1:1 relationship. The term "protein family" should not be confused with family as it is used in taxonomy. Proteins in a family descend from a common ancestor and typically have similar three-dimensional structures, functions, and significant sequence similarity. Sequence similarity (usually amino-acid sequence) is one of the most common indicators of homology, or common evolutionary ancestry. Some frameworks for evaluating the significance of similarity between sequences use sequence alignment methods. Proteins that do not share a common ancestor are unlikely to show statistically significant sequence similarity, making sequence alignment a powerful tool for identifying the members of protein families. Families are sometimes grouped together into larger clades called superfamilies based on st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
