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William Prusoff
William Herman Prusoff (June 25, 1920 – April 3, 2011) was an American pharmacologist who was an early innovator in antiviral drugs, developing idoxuridine, the first antiviral agent approved by the FDA, in the 1950s, and co-developing (with Tai-shun Lin) stavudine, one of the earliest AIDS drugs, in the mid-1980s. Scientific career William Prusoff attended the University of Miami. After receiving his undergraduate degree in chemistry, he obtained his PhD from Columbia University and later completed his postdoctoral training in the laboratory of professor Arnold Welch at Case Western Reserve University. After Welch was recruited by Yale to head the Medical School's pharmacology department, Prusoff was invited to join the same department as an assistant professor and was subsequently promoted to the rank of professor. This relationship at Yale would span over the next 58 years, with William Prusoff becoming one of Yale's most well respected scientists and teachers. Pruso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brooklyn, New York
Brooklyn is a Boroughs of New York City, borough of New York City located at the westernmost end of Long Island in the New York (state), State of New York. Formerly an independent city, the borough is coextensive with Kings County, one of twelve original counties established under English rule in 1683 in what was then the Province of New York. As of the 2020 United States census, the population stood at 2,736,074, making it the most populous of the five boroughs of New York City, and the most populous Administrative divisions of New York (state)#County, county in the state.Table 2: Population, Land Area, and Population Density by County, New York State - 2020 New York State Department of Health. Accessed January 2, 2024. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Undergraduate Degree
An undergraduate degree (also called first degree or simply degree) is a colloquial term for an academic degree earned by a person who has completed undergraduate courses. In the United States, it is usually offered at an institution of higher education, such as a college or university. The most common type of these undergraduate degrees are associate degree and bachelor's degree. Bachelor's degree typically takes at least three or four years to complete. In some other educational systems, undergraduate education is post-secondary education up to the level of a master's degree; this is the case for some science courses in Britain and some long-cycle medicine courses in other European countries. These degrees can be categorised as basic or first professional degrees. Europe United Kingdom In the United Kingdom, a bachelor's degree is the most common type of undergraduate degree. Some master's degrees, known as integrated master's degrees, can be undertaken immediately after fin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Paradigm
In science and philosophy, a paradigm ( ) is a distinct set of concepts or thought patterns, including theories, research methods, postulates, and standards for what constitute legitimate contributions to a field. The word ''paradigm'' is Greek in origin, meaning "pattern". Etymology ''Paradigm'' comes from Greek παράδειγμα (''paradeigma''); "pattern, example, sample"; from the verb παραδείκνυμι (''paradeiknumi''); "exhibit, represent, expose"; and that from παρά (''para''); "beside, beyond"; and δείκνυμι (''deiknumi''); "to show, to point out". In classical (Greek-based) rhetoric, a paradeigma aims to provide an audience with an illustration of a similar occurrence. This illustration is not meant to take the audience to a conclusion; however, it is used to help guide them to get there. One way of how a ''paradeigma'' is meant to guide an audience would be exemplified by the role of a personal accountant. It is not the job of a personal account ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiviral Drug
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Antiviral drugs are a class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to pharmacotherapy, treat infections. They should be distinguished from virucides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Natural virucides are produced by some plants such as eucalyptus and Australian tea trees. Medical uses Most of the antiviral drugs now available are designed to help deal with HIV, Herpesviridae, herpes viruses, the hepatitis B and Hepatitis C, C viruses, and Influenzavirus A, influenza A and Influenzavirus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleoside
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups. In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the molecular building blocks of DNA and RNA. List of nucleosides and corresponding nucleobases ''This list does not include modified nucleobases and the corresponding nucleosides'' Each chemical has a short symbol, useful when the chemical family is clear from the context, and a longer symbol, if further disambiguation is needed. For example, long nucleobase sequences in genomes are usually described by CATG symbols, not Cyt-Ade-Thy-Gua (see '' Nucleic acid sequence § Notation''). Sources Nucleosides can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thymidine
Thymidine (nucleoside#List of nucleosides and corresponding nucleobases, symbol dT or dThd), also known as deoxythymidine, deoxyribosylthymine, or thymine deoxyriboside, is a pyrimidine nucleoside, deoxynucleoside. Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to cell synchronization, synchronize the cells in G1/early S phase. The prefix deoxy- is often left out since there are no precursors of thymine nucleotides involved in RNA synthesis. Before the boom in thymidine use caused by the need for thymidine in the production of the antiretroviral drug Zidovudine, azidothymidine (AZT), much of the world's thymidine production came from herring sperm. Thymidine occurs almost exclusively in DNA but it also occurs in the T arm, T-loop of tRNA. Structure and properties In its composition, deoxythymidine is a nucleoside composed of deoxyribose (a pentose sugar) joined to the pyrimidine base thymine. De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Analog (chemistry)
In chemistry and pharmacology, functional analogs are chemical compounds that have similar physical, chemical, biochemical, or pharmacological properties. Functional analogs are not necessarily structural analogs with a similar chemical structure. An example of pharmacological functional analogs are morphine, heroin and fentanyl, which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage. File:Morphin - Morphine.svg, Morphine File:Heroin - Heroine.svg, Heroin File:Fentanyl2DCSD.svg, Fentanyl Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic (pain medication). It is 30 to 50 times more Potency (pharmacology), potent than heroin and 50 to 100 times more potent than morphine. Its primary Medici ... See also * Federal Analogue Act References Chemical nomenclature Pharmacology {{pharma-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Professor
Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a 'person who professes'. Professors are usually experts in their field and teachers of the highest rank. In most systems of List of academic ranks, academic ranks, "professor" as an unqualified title refers only to the most senior academic position, sometimes informally known as "full professor". In some countries and institutions, the word ''professor'' is also used in titles of lower ranks such as associate professor and assistant professor; this is particularly the case in the United States, where the unqualified word is also used colloquially to refer to associate and assistant professors as well, and often to instructors or lecturers. Professors often conduct original research and commonly teach undergraduate, Postgraduate educa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Assistant Professor
Assistant professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States, Canada, Japan, and South Korea. Overview This position is generally taken after earning a doctoral degree and sometimes after several years of holding one or more postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary acade ...er positions. It is below the position of associate professor at most universities and is equivalent to the rank of lecturer at most Commonwealth universities. In the United States, assistant professor is often the first position held in a tenure track, although it can also be a non-tenure track position. A typical professorship sequence is assistant professor, associate professor, and full professo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, functions, sources, synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, and pharmacokinetics studies the effects of biological systems on a drug. In broad terms, pharmacod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale School Of Medicine
The Yale School of Medicine is the medical school of Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. It is the sixth-oldest medical school in the United States. The school’s faculty clinical practice is Yale Medicine. Yale School of Medicine has a strong affiliation with its primary teaching hospital, Yale New Haven Hospital and the Yale New Haven Health System. The school is home to the Harvey Cushing/John Hay Whitney Medical Library, which is one of the country’s largest modern medical libraries and is known for its historical collections. The faculty includes 31 National Academy of Sciences members, 50 National Academy of Medicine members, and nine Howard Hughes Medical Institute (HHMI) investigators/professors. Yale School of Medicine faculty have also received various international awards for their scientific discoveries, impactful research, and profe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Case Western Reserve University
Case Western Reserve University (CWRU) is a Private university, private research university in Cleveland, Ohio, United States. It was established in 1967 by a merger between Western Reserve University and the Case Institute of Technology. Case Western Reserve University comprises eight schools that offer more than 100 undergraduate programs and about 160 graduate and professional options across fields in STEM, medicine, arts, and the humanities. In 2024, the university enrolled 12,475 students (6,528 undergraduate plus 5,947 graduate and professional) from all 50 states and 106 countries and employed more than 1,182 full-time faculty members. The university's athletic teams, Case Western Reserve Spartans, play in NCAA Division III as a founding member of the University Athletic Association. Case Western Reserve University is a member of the Association of American Universities and is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
