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Webbed Foot
The webbed foot is a specialized limb (anatomy), limb with interdigital webbing, interdigital membranes (webbings) that aids in aquatic locomotion, present in a variety of tetrapod vertebrates. This adaptation is primarily found in semiaquatic species, and has Convergent evolution, convergently evolved many times across vertebrate taxa. It likely arose from mutations in developmental genes that normally cause tissue between the digits to Apoptosis, apoptose. These mutations were beneficial to many semiaquatic animals because the increased surface area from the webbing allowed for more swimming propulsion and swimming efficiency, especially in surface swimmers. The webbed foot also has enabled other novel behaviors like escape responses and mating behaviors. A webbed foot may also be called a paddle to contrast it from a more hydrofoil-like Flipper (anatomy), flipper. Morphology A webbed foot has connecting tissue between the toes of the foot. Several distinct conditions can ...
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Webbed Toes
Webbed toes is the informal and common name for syndactyly affecting the feet—the fusion of two or more digits of the feet. This is normal in many birds, such as ducks; amphibians, such as frogs; and some mammals, such as kangaroos. In humans it is rare, occurring once in about 2,000 to 2,500 live births: most commonly the second and third toes are webbed (joined by skin and flexible tissue), which can reach partly or almost fully up the toe. Cause The exact cause of the condition is unknown. In some cases, close family members may share this condition. In other cases, no other related persons have this condition. The scientific name for the condition is syndactyly, although this term covers both webbed fingers and webbed toes. Syndactyly occurs when apoptosis or programmed cell death during gestation is absent or incomplete. Webbed toes occur most commonly in the following circumstances: * Syndactyly or familial syndactyly * Down syndrome It is also associated with a numbe ...
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Tetrapod
A tetrapod (; from Ancient Greek :wiktionary:τετρα-#Ancient Greek, τετρα- ''(tetra-)'' 'four' and :wiktionary:πούς#Ancient Greek, πούς ''(poús)'' 'foot') is any four-Limb (anatomy), limbed vertebrate animal of the clade Tetrapoda (). Tetrapods include all Neontology#Extant taxa versus extinct taxa, extant and Extinction, extinct amphibians and amniotes, with the latter in turn Evolution, evolving into two major clades, the Sauropsida, sauropsids (reptiles, including dinosaurs and therefore birds) and synapsids (extinct pelycosaur, "pelycosaurs", therapsids and all extant mammals, including Homo sapiens, humans). Hox gene mutations have resulted in some tetrapods becoming Limbless vertebrate, limbless (snakes, legless lizards, and caecilians) or two-limbed (cetaceans, sirenians, Bipedidae, some lizards, kiwi (bird), kiwis, and the extinct moa and elephant birds). Nevertheless, they still qualify as tetrapods through their ancestry, and some retain a pair of ves ...
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Common Frog
The common frog or grass frog (''Rana temporaria''), also known as the European common frog, European common brown frog, European grass frog, European Holarctic true frog, European pond frog or European brown frog or simply the frog, is a semi-aquatic amphibian of the family Ranidae, found throughout much of Europe as far north as Scandinavia and as far east as the Urals, except for most of the Iberian Peninsula, southern Italy, and the southern Balkans. The farthest west it can be found is Ireland. It is also found in Asia, and eastward to Japan. The nominative, and most common, subspecies ''Rana temporaria temporaria'' is a largely terrestrial frog native to Europe. It is distributed throughout northern Europe and can be found in Ireland, the Isle of Lewis and as far east as Japan. Common frogs metamorphose through three distinct developmental life stages — aquatic larva, terrestrial juvenile, and adult. They have corpulent bodies with a rounded snout, webbed feet an ...
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Salamander
Salamanders are a group of amphibians typically characterized by their lizard-like appearance, with slender bodies, blunt snouts, short limbs projecting at right angles to the body, and the presence of a tail in both larvae and adults. All ten extant salamander families are grouped together under the order Urodela, the sole surviving order from the group Caudata. ''Urodela'' is a scientific Latin term based on the Ancient Greek : ourà dēlē "conspicuous tail". ''Caudata'' is the Latin for "tailed ones", from : "tail". Salamander diversity is highest in eastern North America, especially in the Appalachian Mountains; most species are found in the Holarctic realm, with some species present in the Neotropical realm. Salamanders never have more than four toes on their front legs and five on their rear legs, but some species have fewer digits and others lack hind limbs. Their permeable skin usually makes them reliant on habitats in or near water or other cool, damp places. So ...
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Frog
A frog is any member of a diverse and largely semiaquatic group of short-bodied, tailless amphibian vertebrates composing the order (biology), order Anura (coming from the Ancient Greek , literally 'without tail'). Frog species with rough skin texture due to wart-like parotoid glands tend to be called toads, but the distinction between frogs and toads is informal and purely cosmetic, not from taxonomy (biology), taxonomy or evolutionary history. Frogs are widely distributed, ranging from the tropics to subarctic regions, but the greatest concentration of species diversity is in tropical rainforest and associated wetlands. They account for around 88% of extant amphibian species, and are one of the five most diverse vertebrate orders. The oldest fossil "proto-frog" ''Triadobatrachus'' is known from the Early Triassic of Madagascar (250Myr, million years ago), but molecular clock, molecular clock dating suggests their divergent evolution, divergence from other amphibians may exte ...
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Amphibian
Amphibians are ectothermic, anamniote, anamniotic, tetrapod, four-limbed vertebrate animals that constitute the class (biology), class Amphibia. In its broadest sense, it is a paraphyletic group encompassing all Tetrapod, tetrapods, but excluding the amniotes (tetrapods with an amniotic membrane, such as modern reptiles, birds and mammals). All extant taxon, extant (living) amphibians belong to the monophyletic subclass (biology), subclass Lissamphibia, with three living order (biology), orders: Anura (frogs and toads), Urodela (salamanders), and Gymnophiona (caecilians). Evolved to be mostly semiaquatic, amphibians have adapted to inhabit a wide variety of habitats, with most species living in freshwater ecosystem, freshwater, wetland or terrestrial ecosystems (such as riparian woodland, fossorial and even arboreal habitats). Their biological life cycle, life cycle typically starts out as aquatic animal, aquatic larvae with gills known as tadpoles, but some species have devel ...
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Vertebrate Phylogeny With Webbed-Footed Taxa Highlighted
Vertebrates () are animals with a vertebral column (backbone or spine), and a cranium, or skull. The vertebral column surrounds and protects the spinal cord, while the cranium protects the brain. The vertebrates make up the subphylum Vertebrata with some 65,000 species, by far the largest ranked grouping in the phylum Chordata. The vertebrates include mammals, birds, amphibians, and various classes of fish and reptiles. The fish include the jawless Agnatha, and the jawed Gnathostomata. The jawed fish include both the Chondrichthyes, cartilaginous fish and the Osteichthyes, bony fish. Bony fish include the Sarcopterygii, lobe-finned fish, which gave rise to the tetrapods, the animals with four limbs. Despite their success, vertebrates still only make up less than five percent of all described animal species. The first vertebrates appeared in the Cambrian explosion some 518 million years ago. Jawed vertebrates evolved in the Ordovician, followed by bony fishes in the Devonian. T ...
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Bigfoot Splayfoot Salamander
The bigfoot splayfoot salamander (''Chiropterotriton magnipes''), also known as the big-footed salamander, is a species of salamander in the family Plethodontidae. It is endemic to Mexico and only known from north-eastern Queretaro, at elevations of asl. Its natural habitats are caves and crevices in pine–oak forest. It has also been spotted in a tunnel under a church. It is threatened by habitat loss Habitat destruction (also termed habitat loss or habitat reduction) occurs when a natural habitat is no longer able to support its native species. The organisms once living there have either moved elsewhere, or are dead, leading to a decrease ...: removing the forest causes caves to dry up. The species has never been common. References Chiropterotriton Cave salamanders Endemic amphibians of Mexico Amphibians described in 1965 Taxonomy articles created by Polbot Fauna of the Sierra Madre Oriental {{Plethodontidae-stub ...
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Chondrogenesis
Chondrogenesis is the biological process through which cartilage tissue is formed and developed. This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skeleton. The term "chondrogenesis" is derived from the Greek words "chondros," meaning cartilage, and "genesis," meaning origin or formation. Cartilage in fetal development In embryogenesis, the skeletal system is derived from the mesoderm and ectoderm germ layers. Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondrocytes and begins secreting the molecules that form the extracellular matrix. Early in fetal development, the greater part of the skeleton is cartilaginous. This ''temporary'' cartilage is gradually replaced by bone (endochondral ossification), a process that ends at puberty. In contrast, the ...
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TGFβ
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins, inducing transcription of different target genes that function in differentiation, chemotaxis, proliferation, and activation of many immune cells. TGF-β is secreted by many cell types, including macrophages, in a latent form in whic ...
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Cell Signaling
In biology, cell signaling (cell signalling in British English) is the Biological process, process by which a Cell (biology), cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all Cell (biology), cellular life in both prokaryotes and eukaryotes. Typically, the signaling process involves three components: the signal, the receptor, and the effector. In biology, signals are mostly chemical in nature, but can also be physical cues such as pressure, Membrane potential, voltage, temperature, or light. Chemical signals are molecules with the ability to bind and activate a specific Receptor (biochemistry), receptor. These molecules, also referred to as Ligand (biochemistry), ligands, are chemically diverse, including ions (e.g. Na+, K+, Ca2+, etc.), lipids (e.g. steroid, prostaglandin), peptides (e.g. insulin, ACTH), carbohydrates, glycosylated proteins (proteoglycans), nucleic acids, etc. Peptide and lipid ligands are particularly ...
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Bone Morphogenetic Protein
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signalling in pathological processes. Cancerous disease often involves misregulation of the BMP signalling system. Absence of BMP signalling is, for instance, an important factor in the progression of colon cancer, and conversely, overactivation of BMP signalling following reflux-induced esophagitis provokes Barrett's esophagus and is thus instrumental in the development of esophageal adenocarcinoma. Recombinant human BMPs (rhBMPs) are used in orthopedic applications such as spinal fusions, nonunions, an ...
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