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Ust'-Ishim Man
Ust'-Ishim man is the term given to the 45,000-year-old remains of one of the early modern humans to inhabit western Siberia. The fossil is notable in that it had intact DNA which permitted the complete sequencing of its genome, one of the oldest modern human genomes to be so decoded. The remains consist of a single bone—left femur—of a male hunter-gatherer, which was discovered in 2008 protruding from the bank of the Irtysh River by Nikolai Peristov, a Russian sculptor who specialises in carving mammoth ivory. Peristov showed the fossil to a forensic investigator who suggested that it might be of human origin. The fossil was named after the Ust-Ishimsky District of Siberia where it had been discovered. Genome sequencing The fossil was examined by paleoanthropologists in the Max Planck Institute for Evolutionary Anthropology, located in Leipzig, Germany. Carbon dating showed that the fossil dates back to 45,000 years ago, making it the oldest human fossil to be so dat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human
Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing#Evolution of hairlessness, hairlessness, bipedality, bipedalism, and high Human intelligence, intelligence. Humans have large Human brain, brains, enabling more advanced cognitive skills that facilitate successful adaptation to varied environments, development of sophisticated tools, and formation of complex social structures and civilizations. Humans are Sociality, highly social, with individual humans tending to belong to a Level of analysis, multi-layered network of distinct social groups — from families and peer groups to corporations and State (polity), political states. As such, social interactions between humans have established a wide variety of Value theory, values, norm (sociology), social norms, languages, and traditions (co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Sequencing
Whole genome sequencing (WGS), also known as full genome sequencing or just genome sequencing, is the process of determining the entirety of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. Whole genome sequencing should not be confused with DNA profiling, which only determines the likelihood that genetic ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Asia
Central Asia is a region of Asia consisting of Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. The countries as a group are also colloquially referred to as the "-stans" as all have names ending with the Persian language, Persian suffix "-stan" (meaning ) in both respective native languages and most other languages. The region is bounded by the Caspian Sea to the southwest, European Russia to the northwest, China and Mongolia to the east, Afghanistan and Iran to the south, and Siberia to the north. Together, the five Central Asian countries have a total population of around million. In the pre-Islamic and early Islamic eras ( and earlier) Central Asia was inhabited predominantly by Iranian peoples, populated by Eastern Iranian-speaking Bactrians, Sogdians, Khwarezmian language, Chorasmians, and the semi-nomadic Scythians and Dahae. As the result of Turkic migration, Central Asia also became the homeland for the Kazakhs, Kyrgyzs, Volga Tatars, Tatars, Turkmens, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South Asia
South Asia is the southern Subregion#Asia, subregion of Asia that is defined in both geographical and Ethnicity, ethnic-Culture, cultural terms. South Asia, with a population of 2.04 billion, contains a quarter (25%) of the world's population. As commonly conceptualised, the modern State (polity), states of South Asia include Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka, with Afghanistan also often included, which may otherwise be classified as part of Central Asia. South Asia borders East Asia to the northeast, Central Asia to the northwest, West Asia to the west and Southeast Asia to the east. Apart from Southeast Asia, Littoral South Asia, Maritime South Asia is the only subregion of Asia that lies partly within the Southern Hemisphere. The British Indian Ocean Territory and two out of Atolls of Maldives, 26 atolls of the Maldives in South Asia lie entirely within the Southern Hemisphere. Topographically, it is dominated by the Indian subcontinent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autosomal DNA
An autosome is any chromosome that is not a sex chromosome. The members of an autosome pair in a diploid cell have the same morphology, unlike those in allosomal (sex chromosome) pairs, which may have different structures. The DNA in autosomes is collectively known as atDNA or auDNA. For example, humans have a diploid genome that usually contains 22 pairs of autosomes and one allosome pair (46 chromosomes total). The autosome pairs are labeled with numbers (1–22 in humans) roughly in order of their sizes in base pairs, while allosomes are labelled with their letters. By contrast, the allosome pair consists of two X chromosomes in females or one X and one Y chromosome in males. Unusual combinations XYY, XXY, XXX, XXXX, XXXXX or XXYY, among other irregular combinations, are known to occur and usually cause developmental abnormalities. Autosomes still contain sexual determination genes even though they are not sex chromosomes. For example, the SRY gene on the Y chromosome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recent African Origin Of Modern Humans
The recent African origin of modern humans or the "Out of Africa" theory (OOA) is the most widely accepted paleoanthropology, paleo-anthropological model of the geographic origin and Early human migrations, early migration of early modern human, anatomically modern humans (''Human, Homo sapiens''). It follows the early expansions of hominins out of Africa, accomplished by ''Homo erectus'' and then ''Neanderthal, Homo neanderthalensis''. The model proposes a "monogenism, single origin" of ''Human, Homo sapiens'' in the taxonomic sense, precluding parallel evolution in other regions of traits considered anatomically modern humans, anatomically modern, but not precluding multiple Archaic human admixture with modern humans, admixture between ''H. sapiens'' and archaic humans in Europe and Asia. ''H. sapiens'' most likely developed in the Horn of Africa between 300,000 and 200,000 years ago, although an alternative hypothesis argues that diverse morphological features of ''H. sap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Americas
The Americas, sometimes collectively called America, are a landmass comprising the totality of North America and South America.'' Webster's New World College Dictionary'', 2010 by Wiley Publishing, Inc., Cleveland, Ohio. When viewed as a single continent, the Americas or America is the 2nd largest continent by area after Asia, and is the 3rd largest continent by population. The Americas make up most of the land in Earth's Western Hemisphere and comprise the New World. Along with their associated islands, the Americas cover 8% of Earth's total surface area and 28.4% of its land area. The topography is dominated by the American Cordillera, a long chain of mountains that runs the length of the west coast. The flatter eastern side of the Americas is dominated by large river basins, such as the Amazon, St. Lawrence River–Great Lakes, Mississippi, and La Plata basins. Since the Americas extend from north to south, the climate and ecology vary widely, from the arctic tundra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oceania
Oceania ( , ) is a region, geographical region including Australasia, Melanesia, Micronesia, and Polynesia. Outside of the English-speaking world, Oceania is generally considered a continent, while Mainland Australia is regarded as its continental landmass. Spanning the Eastern Hemisphere, Eastern and Western Hemisphere, Western hemispheres, at the centre of the land and water hemispheres, water hemisphere, Oceania is estimated to have a land area of about and a population of around 46.3 million as of 2024. Oceania is the smallest continent in land area and the list of continents and continental subregions by population, second-least populated after Antarctica. Oceania has a diverse mix of economies from the developed country, highly developed and globally competitive market economy, financial markets of Australia, French Polynesia, Hawaii, New Caledonia, and New Zealand, which rank high in quality of life and Human Development Index, to the much least developed countries ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eurasia
Eurasia ( , ) is a continental area on Earth, comprising all of Europe and Asia. According to some geographers, Physical geography, physiographically, Eurasia is a single supercontinent. The concept of Europe and Asia as distinct continents dates back to classical antiquity, antiquity, but their borders have historically been subject to change. For example, the ancient Greeks originally included Africa in Asia but classified Europe as separate land. Eurasia is connected to Africa at the Suez Canal, and the two are sometimes combined to describe the largest contiguous landmass on Earth, Afro-Eurasia. History Eurasia has been the host of many ancient civilizations, including those based in Mesopotamia, Egypt, the Indus Valley and China. In the Axial Age (mid-first millennium BCE), a continuous belt of civilizations stretched through the Eurasian Subtropics, subtropical zone from the Atlantic to the Pacific. This belt became the mainstream of world history for two millennia. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subclades
In genetics, a subclade is a subgroup of a haplogroup. Naming convention Although human mitochondrial DNA (mtDNA) and Y chromosome DNA (Y-DNA) haplogroups and subclades are named in a similar manner, their names belong to completely separate systems. mtDNA mtDNA haplogroups are defined by the presence of a series of single-nucleotide polymorphism (SNP) markers in the hypervariable regions and the coding region of mitochondrial DNA. They are named with the capital letters A through Z, with further subclades named using numbers and lower case letters. Y-DNA Y-DNA haplogroups are defined by the presence of a series of SNP markers on the Y chromosome. Subclades are defined by a ''terminal SNP'', the SNP furthest down in the Y chromosome phylogenetic tree. Human Y-DNA The Y Chromosome Consortium (YCC) developed a system of naming major human Y-DNA haplogroups with the capital letters A through T, with further subclades named using numbers and lower case letters (YCC longhand nomencl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haplogroup R (mtDNA)
Haplogroup R is a widely distributed Human mitochondrial DNA haplogroup, human mitochondrial DNA (mtDNA) haplogroup. Haplogroup R is associated with the peopling of Eurasia after about 70,000 years ago, and is distributed in modern populations throughout the world outside of archaeogenetics of sub-Saharan Africa, sub-Saharan Africa. Haplogroup R is a descendant of the macro-Haplogroup N (mtDNA), haplogroup N. Among the R clade's descendant haplogroups are Haplogroup B (mtDNA), B, haplogroup U (mtDNA), U (and thus haplogroup K (mtDNA), K), Haplogroup F (mtDNA), F, Haplogroup R0 (mtDNA), R0 (and thus Haplogroup HV (mtDNA), HV, Haplogroup H (mtDNA), H, and Haplogroup V (mtDNA), V), and Haplogroup JT (mtDNA), JT (the ancestral haplogroup of Haplogroup J (mtDNA), J and Haplogroup T (mtDNA), T). Origin Soares et al. (2009) estimate the age of haplogroup R at roughly 50,000 to 70,000 years ago. This is consistent with an emergence in the course of the Southern Dispersal out of East A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Mitochondrial DNA Haplogroup
In human genetics, a human mitochondrial DNA haplogroup is a haplogroup defined by differences in human mitochondrial DNA. Haplogroups are used to represent the major branch points on the mitochondrial phylogenetic tree. Understanding the evolutionary path of the female lineage has helped population geneticists trace the matrilineal inheritance of modern humans back to human origins in Africa and the subsequent spread around the globe. The letter names of the haplogroups (not just mitochondrial DNA haplogroups) run from A to Z. As haplogroups were named in the order of their discovery, the alphabetical ordering does not have any meaning in terms of actual genetic relationships. The hypothetical woman at the root of all these groups (meaning just the mitochondrial DNA haplogroups) is the matrilineal most recent common ancestor (MRCA) for all currently living humans. She is commonly called Mitochondrial Eve. The rate at which mitochondrial DNA mutates is known as the m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
