|
Tob1
Protein Tob1 is a protein that in humans is encoded by the ''TOB1'' gene. Function This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. Interactions TOB1 has been shown to interact with: * CNOT7, * MAPK1 * MARCKS, * Mitogen-activated protein kinase 9, and * RPS6KA1 Ribosomal protein S6 kin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNOT7
CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the ''CNOT7'' gene. It is a subunit of the CCR4-Not deadenylase complex. Function The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Interactions CNOT7 has been shown to interact with: * BTG1, * PABPC1, * TOB1, and * TOB2 Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the ''TOB2'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MAPK1
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the ''MAPK1'' gene. Function The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated. Interactions MAPK1 has been shown to interact with: * ADAM17, * CIITA, * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MARCKS
Marcks is a surname. Notable people with the surname include: * Erich Marcks (1891–1944), German general * Gerhard Marcks (1889–1981), German sculptor * Greg Marcks (born 1976), American director, writer and actor * Megan Marcks (born 1972), Australian rower * Werner Marcks (1896–1967), German general See also * 10778 Marcks, a main-belt asteroid * Marks (other) * Marks (surname) * Marx (other) * Marx (surname) The surname Marx is a Germanic surname, believed to originate with Mark the Evangelist and the Roman praenomen Marcus, the latter deriving from the god Mars. The similarly-spelled Marks may share etymology with march (territory), especially near Wa ... {{surname, Marcks Surnames from given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitogen-activated Protein Kinase 9
Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the ''MAPK9'' gene. Function The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
