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Tiffeneau–Demjanov Rearrangement
The Tiffeneau–Demjanov rearrangement (TDR) is the chemical reaction of a 1-aminomethyl-cycloalkanol with nitrous acid to form an enlarged cycloketone. The Tiffeneau–Demjanov ring expansion, Tiffeneau–Demjanov rearrangement, or TDR, provides an easy way to increase amino-substituted cycloalkanes and cycloalkanols in size by one carbon. Ring sizes from cyclopropane through cyclooctane are able to undergo Tiffeneau–Demjanov ring expansion with some degree of success. Yields decrease as initial ring size increases, and the ideal use of TDR is for synthesis of five, six, and seven membered rings. A principal synthetic application of Tiffeneau–Demjanov ring expansion is to bicyclic or polycyclic systems. Several reviews on this reaction have been published. Discovery The reaction now known as the Tiffeneau–Demjanov rearrangement (TDR) was discovered in two steps. The first step of occurred in 1901 when Russian chemist Nikolai Demyanov discovered that aminomethylcycloalka ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marc Tiffeneau
Marc Émile Pierre Adolphe Tiffeneau (November 5, 1873 – May 20, 1945) was a French chemist who co-discovered the Tiffeneau-Demjanov rearrangement. In 1899 he graduated from the École de pharmacie de Paris, and afterwards began work as a pharmacy intern in Paris hospitals. In 1904 he was named chief pharmacist at the Hôpital Boucicaut,Marc Pierre Emile TIFFENEAU (1873-1945) Société d'Histoire de la Pharmacie and from 1927, worked in a similar capacity at the . From 1926 to 1944 he was a professor of to the facult ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxonium Ion
In chemistry, an oxonium ion is any cation containing an oxygen atom that has three bonds and 1+ formal charge. The simplest oxonium ion is the hydronium ion (). Alkyloxonium Hydronium is one of a series of oxonium ions with the formula R''n''H3−''n''O+. Oxygen is usually pyramidal with an sp3 hybridization. Those with ''n'' = 1 are called primary oxonium ions, an example being protonated alcohol (e.g. methanol). In acidic media, the oxonium functional group produced by protonating an alcohol can be a leaving group in the E2 elimination reaction. The product is an alkene. Extreme acidity, heat, and dehydrating conditions are usually required. Other hydrocarbon oxonium ions are formed by protonation or alkylation of alcohols or ethers (R−C−−R1R2). Secondary oxonium ions have the formula R2OH+, an example being protonated ethers. Tertiary oxonium ions have the formula R3O+, an example being trimethyloxonium. Tertiary alkyloxonium salts are useful alkylating ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Melbourne
The University of Melbourne is a public research university located in Melbourne, Australia. Founded in 1853, it is Australia's second oldest university and the oldest in Victoria. Its main campus is located in Parkville, an inner suburb north of Melbourne's central business district, with several other campuses located across Victoria. Incorporated in the 19th century by the colony of Victoria, the University of Melbourne is one of Australia's six sandstone universities and a member of the Group of Eight, Universitas 21, Washington University's McDonnell International Scholars Academy, and the Association of Pacific Rim Universities. Since 1872, many residential colleges have become affiliated with the university, providing accommodation for students and faculty, and academic, sporting and cultural programs. There are ten colleges located on the main campus and in nearby suburbs. The university comprises ten separate academic units and is associated with numerous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norcamphor
Norcamphor is an organic compound, classified as a bicyclic ketone. It is an analog of camphor, but without the three methyl groups. A colorless solid, it is used as a building block in organic synthesis. Norcamphor is prepared from norbornene via the 2-formate ester, which is oxidized. It is a useful precursor to norborneols. See also * Norbornane Norbornane (also known as bicyclo .2.1eptane) is an organic compound and a saturated hydrocarbon with chemical formula C7H12. It is a crystalline compound with a melting point of 88 °C. The carbon skeleton is derived from cyclohexane ring with a ... References Ketones Cyclopentanes Norbornanes {{ketone-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marquette University
Marquette University () is a Private university, private Society of Jesus, Jesuit research university in Milwaukee, Wisconsin. Established by the Society of Jesus as Marquette College on August 28, 1881, it was founded by John Henni, John Martin Henni, the first Roman Catholic Archdiocese of Milwaukee, Bishop of the diocese of Milwaukee, Wisconsin. The university was named after 17th-century missionary and explorer Father Jacques Marquette, SJ, with the intention to provide an affordable Catholic education to the area's emerging German American, German immigrant population. Initially an all-male institution, Marquette became the first coeducational Catholic university in the world in 1909 when it began admitting its first female students. Marquette is part of the Association of Jesuit Colleges and Universities. The university is accredited by the Higher Learning Commission and currently has a student body of about 12,000. It is Carnegie Classification of Institutions of Higher E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electronic Effect An electronic effect influences the structure, reactivity, or properties of molecule but is neither a traditional bon |
