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Thomas Lecuit
Thomas Lecuit, born 4 October 1971 in Saumur, is a French biologist specializing in the emergence of forms or morphogenesis. He is a professor at the Collège de France, holding the Dynamics of Life Chair. He leads a research team at the Institut de Biologie du Développement de Marseille (IBDM), and the Turing Centre for Living Systems, an interdisciplinary centre dedicated to the study of living organisms. Biography Thomas Lecuit grew up in Saumur, from medical parents who gave him a broad education, open to the arts, the humanities and science. He develops early a marked attraction for the things of nature, which arouse his curiosity. After a scientific baccalaureate (1989) he began studies in the preparatory class at the Lycée Sainte Geneviève, and in 1991 he entered the École Normale Supérieure. In 1993-1994, he completed a decisive research internship at the Rockefeller University in New York under the direction of Claude Desplan, who introduced him to the world of r ...
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Saumur
Saumur () is a Communes of France, commune in the Maine-et-Loire Departments of France, department in western France. The town is located between the Loire and Thouet rivers, and is surrounded by the vineyards of Saumur itself, Chinon, Bourgueil, Coteaux du Layon, etc.. Saumur station has rail connections to Tours, Angers, La Roche-sur-Yon and Nantes. Toponymy First attested in the Medieval Latin form of ''Salmuri'' in 968 AD, the origin of the name is obscure. Albert Dauzat hypothesized a pre-Celtic unattested element ''*sala'' 'marshy ground' (''cf.'' Celtic ''salm'' 'which jumps and flows'), followed by another unattested element meaning "wall". Many places in Europe seem to contain ''*Sal(m)-'' elements, which may share Old European hydronymy, Old European roots. History The Dolmen de Bagneux on the south of the town, is 23 meters long and is built from 15 large slabs of the local stone, weighing over 500 tons. It is the largest in France. The Château de Saumur was cons ...
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Physicist
A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe. Physicists generally are interested in the root or ultimate causes of Phenomenon, phenomena, and usually frame their understanding in mathematical terms. They work across a wide range of Physics#Research fields, research fields, spanning all length scales: from atom, sub-atomic and particle physics, through biological physics, to physical cosmology, cosmological length scales encompassing the universe as a whole. The field generally includes two types of physicists: Experimental physics, experimental physicists who specialize in the observation of natural phenomena and the development and analysis of experiments, and Theoretical physics, theoretical physicists who specialize in mathematical modeling of physical systems to rationalize, explain and predict natural phenomena. Physicists can apply their k ...
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European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds courses, workshops and conferences, publishes five scientific journals and supports individual scientists. The organization was founded in 1964 and is a founding member of the Initiative for Science in Europe. the Director of EMBO is Fiona Watt, a stem cell researcher, professor at King's College London and a group leader at the European Molecular Biology Laboratory. __TOC__ Conferences and journals In recent years, EMBO has funded more than 80 meetings with more than 12,000 participants each year. EMBO publishes five peer-reviewed scientific journals: ''The EMBO Journal'', ''EMBO Reports'', '' Molecular Systems Biology'', '' EMBO Molecular Medicine'', and '' Life Science Alliance''. History The European Molecular Biology Organizatio ...
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Academia Europaea
The Academia Europaea is a pan-European Academy of humanities, letters, law, and sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of European interests in national research agencies. History The concept of a 'European Academy of Sciences' was raised at a meeting in Paris of the European Ministers of Science in 1985. The initiative was taken by the Royal Society (United Kingdom) which resulted in a meeting in London in June 1986 of Arnold Burgen (United Kingdom), Hubert Curien (France), Umberto Colombo (Italy), David Magnusson (Sweden), Eugen Seibold (Germany) and Ruurd van Lieshout (the Netherlands) – who agreed to the need for a new body. The meeting also included Brian Flowers and John Kendrew. Another, larger meeting took place in October 1986 with participants representing some countries in the Council of Europe and was in support for the development of a Eur ...
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D'Arcy Wentworth Thompson
Sir D'Arcy Wentworth Thompson CB FRS FRSE (2 May 1860 – 21 June 1948) was a Scottish biologist, mathematician and classics scholar. He was a pioneer of mathematical and theoretical biology, travelled on expeditions to the Bering Strait and held the position of Professor of Natural History at University College, Dundee for 32 years, then at St Andrews for 31 years. He was elected a Fellow of the Royal Society, was knighted, and received the Darwin Medal and the Daniel Giraud Elliot Medal. Thompson is remembered as the author of the 1917 book '' On Growth and Form'', which led the way for the scientific explanation of morphogenesis, the process by which patterns and body structures are formed in plants and animals. Thompson's description of the mathematical beauty of nature, and the mathematical basis of the forms of animals and plants, stimulated thinkers as diverse as Julian Huxley, C. H. Waddington, Alan Turing, René Thom, Claude Lévi-Strauss, Eduardo Paolo ...
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Cellularization
In evolutionary biology, the term cellularization (cellularisation) has been used in theories to explain the evolution of cells, for instance in the ''pre-cell theory'', dealing with the evolution of the first cells on this planet, and in the ''syncytial theory'' attempting to explain the origin of Metazoa from unicellular organisms. Processes of cell development in multinucleate cells ( syncytium, plural syncytia) of animals and plants are also termed cellularization, often called ''syncytium cellularization''. The pre-cell theory According to Otto Kandler's pre-cell theory, early evolution of life and primordial metabolism (see Iron-Sulfur world hypothesis - metabolism first scenario, according to Wächtershäuser) led to the early diversification of life through the evolution of a multiphenotypical population of pre-cells, from which the three founder groups A, B, C and then, from them, the precursor cells (here named proto-cells) of the three domains of life emerged s ...
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Fluorescence
Fluorescence is one of two kinds of photoluminescence, the emission of light by a substance that has absorbed light or other electromagnetic radiation. When exposed to ultraviolet radiation, many substances will glow (fluoresce) with colored visible light. The color of the light emitted depends on the chemical composition of the substance. Fluorescent materials generally cease to glow nearly immediately when the radiation source stops. This distinguishes them from the other type of light emission, phosphorescence. Phosphorescent materials continue to emit light for some time after the radiation stops. This difference in duration is a result of quantum spin effects. Fluorescence occurs when a photon from incoming radiation is absorbed by a molecule, exciting it to a higher energy level, followed by the emission of light as the molecule returns to a lower energy state. The emitted light may have a longer wavelength and, therefore, a lower photon energy than the absorbed radi ...
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Morphogen
A morphogen is a substance whose non-uniform distribution governs the pattern of tissue development in the process of morphogenesis or pattern formation, one of the core processes of developmental biology, establishing positions of the various specialized cell types within a tissue. More specifically, a morphogen is a signaling molecule that acts directly on cells to produce specific cellular responses depending on its local concentration. Typically, morphogens are produced by source cells and diffuse through surrounding tissues in an embryo during early development, such that concentration gradients are set up. These gradients drive the process of differentiation of unspecialised stem cells into different cell types, ultimately forming all the tissues and organs of the body. The control of morphogenesis is a central element in evolutionary developmental biology (evo-devo). History The term was coined by Alan Turing in the paper " The Chemical Basis of Morphogenesis", where ...
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Francis Crick
Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Rosalind Franklin, and Maurice Wilkins played crucial roles in deciphering the Nucleic acid double helix, helical structure of the DNA molecule. Crick and Watson's paper in ''Nature (journal), Nature'' in 1953 laid the groundwork for understanding DNA structure and functions. Together with Maurice Wilkins, they were jointly awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular geometry, molecular structure of nucleic acids and its significance for information transfer in living material". Crick was an important theoretical molecular biologist and played a crucial role in research related to revealing the helical structure of DNA. He is widely known for the use of the term "central dogma" to summarise the idea that once information is transferred from nucleic acids (DNA or RNA) to prot ...
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Lewis Wolpert
Lewis Wolpert (19 October 1929 – 28 January 2021) was a South African-born British developmental biologist, author, and broadcaster. Wolpert popularized his French flag model of embryonic development, using the colours of the French flag as a visual aid to explain how embryonic cells interpret genetic code for expressing characteristics of living organisms and explaining how signalling between cells early in morphogenesis could inform cells with the same genetic regulatory network of their position and role. He wrote several science books, including: ''Triumph of the Embryo'' (1991), ''Malignant Sadness'' (1999), ''Six Impossible Things Before Breakfast: the Evolutionary Origins of Belief'' (2006), and ''How We Live And Why We Die: The Secret Lives of Cells'' (2009). Early life Wolpert was born on 19 October 1929, in Johannesburg to Sarah (née Suzman) and William Wolpert in a South African Jewish family of Lithuanian Jewish origin. His father was a bookshop manager ...
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Alan Turing
Alan Mathison Turing (; 23 June 1912 – 7 June 1954) was an English mathematician, computer scientist, logician, cryptanalyst, philosopher and theoretical biologist. He was highly influential in the development of theoretical computer science, providing a formalisation of the concepts of algorithm and computation with the Turing machine, which can be considered a model of a general-purpose computer. Turing is widely considered to be the father of theoretical computer science. Born in London, Turing was raised in southern England. He graduated from University of Cambridge, King's College, Cambridge, and in 1938, earned a doctorate degree from Princeton University. During World War II, Turing worked for the Government Code and Cypher School at Bletchley Park, Britain's codebreaking centre that produced Ultra (cryptography), Ultra intelligence. He led Hut 8, the section responsible for German naval cryptanalysis. Turing devised techniques for speeding the breaking of Germ ...
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Embryo
An embryo ( ) is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm cell. The resulting fusion of these two cells produces a single-celled zygote that undergoes many cell divisions that produce cells known as blastomeres. The blastomeres (4-cell stage) are arranged as a solid ball that when reaching a certain size, called a morula, (16-cell stage) takes in fluid to create a cavity called a blastocoel. The structure is then termed a blastula, or a blastocyst in mammals. The mammalian blastocyst hatches before implantating into the endometrial lining of the womb. Once implanted the embryo will continue its development through the next stages of gastrulation, neurulation, and organogenesis. Gastrulation is the formation of the three germ layers that will form all of the different parts of t ...
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