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QT Interval
The QT interval is a measurement made on an Electrocardiography, electrocardiogram used to assess some of the electrical properties of the heart. It is calculated as the time from the start of the QRS complex, Q wave to the end of the T wave, and approximates to the time taken from when the Ventricle (heart), cardiac ventricles start to contract to when they finish relaxing. An abnormally long or abnormally short QT interval is associated with an increased risk of developing Heart arrhythmia, abnormal heart rhythms and Cardiac arrest, sudden cardiac death. Abnormalities in the QT interval can be caused by Genetics, genetic conditions such as long QT syndrome, by certain medications such as fluconazole, sotalol or pitolisant, by disturbances in the concentrations of certain Electrolyte, salts within the blood such as Hypokalemia, hypokalaemia, or by Endocrine disease, hormonal imbalances such as hypothyroidism. Measurement The QT interval is most commonly measured in Electrocardi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrocardiography
Electrocardiography is the process of producing an electrocardiogram (ECG or EKG), a recording of the heart's electrical activity through repeated cardiac cycles. It is an electrogram of the heart which is a graph of voltage versus time of the electrical activity of the heart using electrodes placed on the skin. These electrodes detect the small electrical changes that are a consequence of cardiac muscle depolarization followed by repolarization during each cardiac cycle (heartbeat). Changes in the normal ECG pattern occur in numerous cardiac abnormalities, including: * Cardiac rhythmicity, Cardiac rhythm disturbances, such as atrial fibrillation and ventricular tachycardia; * Inadequate coronary artery blood flow, such as myocardial ischemia and myocardial infarction; * and electrolyte disturbances, such as hypokalemia. Traditionally, "ECG" usually means a 12-lead ECG taken while lying down as discussed below. However, other devices can record the electrical activity of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heart Rate
Heart rate is the frequency of the cardiac cycle, heartbeat measured by the number of contractions of the heart per minute (''beats per minute'', or bpm). The heart rate varies according to the body's Human body, physical needs, including the need to absorb oxygen and excrete carbon dioxide. It is also modulated by numerous factors, including (but not limited to) genetics, physical fitness, Psychological stress, stress or psychological status, diet, drugs, hormonal status, environment, and disease/illness, as well as the interaction between these factors. It is usually equal or close to the pulse rate measured at any peripheral point. The American Heart Association states the normal resting adult human heart rate is 60–100 bpm. An ultra-trained athlete would have a resting heart rate of 37–38 bpm. ''Tachycardia'' is a high heart rate, defined as above 100 bpm at rest. ''Bradycardia'' is a low heart rate, defined as below 60 bpm at rest. When a human sleeps, a heartbeat with ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NOS1AP
Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the ''NOS1AP'' gene. This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. NOS1AP polymorphisms has been associated with the QT interval The QT interval is a measurement made on an Electrocardiography, electrocardiogram used to assess some of the electrical properties of the heart. It is calculated as the time from the start of the QRS complex, Q wave to the end of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Short QT Syndrome
Short QT syndrome (SQT) is a very rare genetics, genetic disease of the electrical system of the heart, and is associated with an increased risk of Heart arrhythmia, abnormal heart rhythms and sudden cardiac death. The syndrome gets its name from a characteristic feature seen on an Electrocardiography, electrocardiogram (ECG) – a shortening of the QT interval. It is caused by mutations in genes encoding ion channels that shorten the cardiac action potential, and appears to be inherited in an autosomal dominant pattern. The condition is diagnosed using a Electrocardiography, 12-lead ECG. Short QT syndrome can be treated using an implantable cardioverter-defibrillator or medications including quinidine. Short QT syndrome was first described in 2000, and the first genetic mutation associated with the condition was identified in 2004. Signs and symptoms Those affected by short QT syndrome (SQT) have an increased risk of developing Heart arrhythmia, abnormal heart rhythms. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
QT Distribution
QT or Qt may refer to: Businesses * The Qt Company, a Finnish software developer * QT Hotels & Resorts, an Australasian hospitality provider * QT Inc., an American bracelet manufacturer * QuikTrip, an American convenience store chain People * QT (musician) (born 1988), American pop singer * QTCinderella (born 1994), American Twitch streamer and YouTuber * Q-Tee, British rapper (active in the 1990s) * Quentin Tarantino (born 1963), American filmmaker Science and technology Computer software * Qt (software), a cross-platform application framework * QuickTime, a multimedia technology from Apple Inc. Heart medicine * QT interval, on an electrocardiogram ** Long QT syndrome, a rare condition ** Short QT syndrome, a very rare disease Units of measure * Quart (qt), an imperial unit of volume Television shows * '' QT: QueerTelevision'', a 1990s Canadian LGBT newsmagazine * ''Question Time'' (TV programme), a British panel debate (first aired 1979) Transport * QT (New York City ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Torsades De Pointes
''Torsades de pointes, torsade de pointes'' or ''torsades des pointes'' (TdP; also called ''torsades'') (, , translated as "twisting of peaks") is a specific type of abnormal heart rhythm that can lead to sudden cardiac death. It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG). It was described by French physician François Dessertenne in 1966. Prolongation of the QT interval can increase a person's risk of developing this abnormal heart rhythm, occurring in between 1% and 10% of patients who receive QT-prolonging antiarrhythmic drugs. Signs and symptoms Most episodes will revert spontaneously to a normal sinus rhythm. Symptoms and consequences include palpitations, dizziness, lightheadedness (during shorter episodes), fainting (during longer episodes), and sudden cardiac death. Causes Torsades occurs as both an inherited (linked to at least 17 genes) and as an acquired form caused most often by drugs a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ventricular Fibrillation
Ventricular fibrillation (V-fib or VF) is an abnormal heart rhythm in which the Ventricle (heart), ventricles of the heart Fibrillation, quiver. It is due to disorganized electrical conduction system of the heart, electrical activity. Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. This is followed by sudden cardiac death in the absence of treatment. Ventricular fibrillation is initially found in about 10% of people with cardiac arrest. Ventricular fibrillation can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, long QT syndrome, electric shock, or intracranial hemorrhage. Diagnosis is by an electrocardiogram (ECG) showing irregular unformed QRS complexes without any clear P wave (electrocardiography), P waves. An important differential diagnosis is torsades de pointes. Treatment is with cardiopulmonary resuscitation (CPR) and defibrillation. Defibrillation#Change to a biphasic waveform, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sudden Cardiac Death
Cardiac arrest (also known as sudden cardiac arrest ''SCA is when the heart suddenly and unexpectedly stops beating. When the heart stops beating, blood cannot properly circulate around the body and the blood flow to the brain and other organs is decreased. When the brain does not receive enough blood, this can cause a person to lose consciousness and brain cells can start to die due to lack of oxygen. Coma and persistent vegetative state may result from cardiac arrest. Cardiac arrest is also identified by a lack of central pulses and abnormal or absent breathing. Cardiac arrest and resultant hemodynamic collapse often occur due to arrhythmias (irregular heart rhythms). Ventricular fibrillation and ventricular tachycardia are most commonly recorded. However, as many incidents of cardiac arrest occur out-of-hospital or when a person is not having their cardiac activity monitored, it is difficult to identify the specific mechanism in each case. Structural heart disease, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
QT Interval Corrected For Heart Rate
QT or Qt may refer to: Businesses * The Qt Company, a Finnish software developer * QT Hotels & Resorts, an Australasian hospitality provider * QT Inc., an American bracelet manufacturer * QuikTrip, an American convenience store chain People * QT (musician) (born 1988), American pop singer * QTCinderella (born 1994), American Twitch streamer and YouTuber * Q-Tee, British rapper (active in the 1990s) * Quentin Tarantino (born 1963), American filmmaker Science and technology Computer software * Qt (software), a cross-platform application framework * QuickTime, a multimedia technology from Apple Inc. Heart medicine * QT interval, on an electrocardiogram ** Long QT syndrome, a rare condition ** Short QT syndrome, a very rare disease Units of measure * Quart (qt), an imperial unit of volume Television shows * '' QT: QueerTelevision'', a 1990s Canadian LGBT newsmagazine * ''Question Time'' (TV programme), a British panel debate (first aired 1979) Transport * QT (New York City ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Retrospective Study
A retrospective cohort study, also called a historic cohort study, is a longitudinal cohort study used in medical and psychological research. A cohort of individuals that share a common exposure factor is compared with another group of equivalent individuals not exposed to that factor, to determine the factor's influence on the incidence of a condition such as disease or death. Retrospective cohort studies have existed for approximately as long as prospective cohort studies. Design The retrospective cohort study compares groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke and ones who do not smoke) in terms of a particular outcome (such as lung cancer). Data on the relevant events for each individual (the form and time of exposure to a factor, the latent period, and the time of any subsequent occurrence of the outcome) are collected from existing records and can immediately be analyzed to determine the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Verify Source
CONFIG.SYS is the primary configuration file for the DOS and OS/2 operating systems. It is a special ASCII text file that contains user-accessible setup or configuration directives evaluated by the operating system's DOS BIOS (typically residing in IBMBIO.COM or IO.SYS) during boot. CONFIG.SYS was introduced with DOS 2.0. Usage The directives in this file configure DOS for use with devices and applications in the system. The CONFIG.SYS directives also set up the memory managers in the system. After processing the CONFIG.SYS file, DOS proceeds to load and execute the command shell specified in the SHELL line of CONFIG.SYS, or COMMAND.COM if there is no such line. The command shell in turn is responsible for processing the AUTOEXEC.BAT file. CONFIG.SYS is composed mostly of name=value directives which look like variable assignments. In fact, these will either define some tunable parameters often resulting in reservation of memory, or load files, mostly device drivers and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Framingham Heart Study
The Framingham Heart Study is a long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of participants. Prior to the study almost nothing was known about the epidemiology of hypertensive or arteriosclerotic cardiovascular disease. Much of the now-common knowledge concerning heart disease, such as the effects of diet, exercise, and common medications such as aspirin, is based on this longitudinal study. It is a project of the National Heart, Lung, and Blood Institute, in collaboration with (since 1971) Boston University. Various health professionals from the hospitals and universities of Greater Boston staff the project. History In 1948, the study was commissioned by the United States Congress, with multiple communities being considered for study. The final choice was between Framingham, Massachusetts, and Paintsville, Kentucky. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
