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Prader
Prader may refer to: * Andrea Prader (1919–2001) *Prader–Willi syndrome Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a loss of function of specific genes on chromosome 15. In newborns, symptoms include hypotonia, weak muscles, poor feeding, and slow development. Beginning in childhood, those ... * Prader scale {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prader–Willi Syndrome
Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a loss of function of specific genes on chromosome 15. In newborns, symptoms include hypotonia, weak muscles, poor feeding, and slow development. Beginning in childhood, those affected become constantly hungry, which often leads to obesity and type 2 diabetes. Mild to moderate intellectual impairment and Behavioural problems, behavioral problems are also typical of the disorder. Often, affected individuals have a narrow forehead, small hands and feet, short height, and light skin and hair. Most are Infertility, unable to have children. About 74% of cases occur when part of the father's chromosome 15 is deleted. In another 25% of cases, the affected person has Uniparental disomy, two copies of the maternal chromosome 15 from the mother and lacks the paternal copy. As parts of the chromosome from the mother are turned off through Genomic imprinting, imprinting, they end up with no working copies of certain genes. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andrea Prader
Andrea Prader (December 23, 1919 – June 3, 2001) was a Swiss scientist, physician, and pediatric endocrinologist. He co-discovered Prader–Willi syndrome and created two physiological sex development scales, the Prader scale and the orchidometer. Biography Andrea Prader was born in Samedan (Canton of Grisons - Courtry of Switzerland but lived in Zurich most of his life. He attended medical school at the University of Zurich. During his residency between 1944 and 1946, he worked under Gian Töndury in the Department of Anatomy in Zurich, and then in 1947 in the Department of Outpatient Medicine in Lausanne under Alfredo Vannotti. In 1947, he became assistant physician at the Children's Hospital in Zürich. In 1950 was the beginning of his career as pediatric endocrinologist. His advanced research brought him to the U.S. in the early 1950s; Prader specialized at the Bellevue Hospital, New York City under the guidance of L.E. Holt, Jr, son of Luther Emmett Holt. His lasting i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
