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Pleiotropy
Pleiotropy () is a condition in which a single gene or genetic variant influences multiple phenotypic traits. A gene that has such multiple effects is referred to as a ''pleiotropic gene''. Mutations in pleiotropic genes can impact several traits simultaneously, often because the gene product is used in various cell (biology), cells and affects different biological targets through shared signaling pathways. Pleiotropy can result from several distinct but potentially overlapping mechanisms, including gene pleiotropy, developmental biology, developmental pleiotropy, and selectional pleiotropy. Gene pleiotropy occurs when a gene product interacts with multiple proteins or catalyzes different reactions. Developmental pleiotropy refers to mutations that produce several phenotype, phenotypic effects during development. Selectional pleiotropy occurs when a single phenotype influences evolutionary fitness (biology), fitness in multiple ways (depending on factors such as age and sex). T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Correlation
In multivariate quantitative genetics, a genetic correlation (denoted r_g or r_a) is the proportion of variance that two traits share due to genetic causes, the correlation between the genetic influences on a trait and the genetic influences on a different trait#Plomin, Plomin et al., p. 123 estimating the degree of pleiotropy or causal overlap. A genetic correlation of 0 implies that the genetic effects on one trait are independent of the other, while a correlation of 1 implies that all of the genetic influences on the two traits are identical. The bivariate genetic correlation can be generalized to inferring genetic latent variable factors across > 2 traits using factor analysis. Genetic correlation models were introduced into behavioral genetics in the 1970s–1980s. Genetic correlations have applications in validation of genome-wide association study (GWAS) results, breeding, prediction of traits, and discovering the etiology of traits & diseases. They can be estimated usi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ludwig Plate
Ludwig Hermann Plate (16 August 1862 – 16 November 1937) was a German zoologist and student of Ernst Haeckel. He wrote a "thorough and extensive defence" of Darwinism, but before Mendel's work had been assimilated in the modern synthesis. Born in Bremen, Plate studied mathematics and natural sciences Bonn and in Jena, where he attended the lectures of Ernst Haeckel. In 1888, he achieved the 'Habilitation' in zoology at the University of Marburg. He was offered the Chair of Zoology at Jena University in 1909 through the help of Haeckel, and also became director of the Jena "Phyletisches Museum". Levit, Georgy S; Olsson, Lennart. (2007). ''Evolution on Rails Mechanisms and Levels of Orthogenesis''. In Volker Wissemann. ''Annals of the History and Philosophy of Biology 11/2006''. Universitätsverlag Göttingen. pp. 113-115. He coined the term Pleiotropy. Evolutionary views Plate was a proponent of what he called ''old-Darwinism'' or ''orthoevolution'', which included a supp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GWAS Catalog
The GWAS catalog is a free online database that compiles data of genome-wide association studies (GWAS), summarizing unstructured data from different literature sources into accessible high quality data. It was created by the National Human Genome Research Institute (NHGRI) in 2008 and have become a collaborative project between the NHGRI and the European Bioinformatics Institute (EBI) since 2010. As of September 2018, it has included 71,673 SNP–trait associations in 3,567 publications. A GWAS identifies genetic loci associated with common traits and disease through the analysis of categorized variants across the genome and the catalog provides information from all published GWAS results that meet its criteria. The catalog contains publication information, study groups information (origin, size) and SNP-disease association information (including SNP identifier, P-value, gene and risk allele). Over the years, the GWAS catalog has enhanced its data release frequency by adding fe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
One Gene-one Enzyme Hypothesis
1 (one, unit, unity) is a number, numeral, and glyph. It is the first and smallest positive integer of the infinite sequence of natural numbers. This fundamental property has led to its unique uses in other fields, ranging from science to sports, where it commonly denotes the first, leading, or top thing in a group. 1 is the unit of counting or measurement, a determiner for singular nouns, and a gender-neutral pronoun. Historically, the representation of 1 evolved from ancient Sumerian and Babylonian symbols to the modern Arabic numeral. In mathematics, 1 is the multiplicative identity, meaning that any number multiplied by 1 equals the same number. 1 is by convention not considered a prime number. In digital technology, 1 represents the "on" state in binary code, the foundation of computing. Philosophically, 1 symbolizes the ultimate reality or source of existence in various traditions. In mathematics The number 1 is the first natural number after 0. Each natural numbe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward Tatum
Edward Lawrie Tatum (December 14, 1909 – November 5, 1975) was an American geneticist. He shared half of the Nobel Prize in Physiology or Medicine in 1958 with George Beadle for showing that genes control individual steps in metabolism. The other half of that year's award went to Joshua Lederberg. Tatum was an elected member of the United States National Academy of Sciences, the American Philosophical Society, and the American Academy of Arts and Sciences. Education Edward Lawrie Tatum was born on December 14, 1909, in Boulder, Colorado to Arthur L. Tatum and Mabel Webb Tatum. Arthur L. Tatum was a chemistry professor, who by 1925 was a professor of pharmacology at the University of Wisconsin at Madison. Edward Lawrie Tatum attended college at the University of Chicago for two years, before transferring to the University of Wisconsin–Madison, where he received his BA in 1931 and PhD in 1934. His dissertation was ''Studies in the biochemistry of microorganisms'' (1934). Ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Beadle
George Wells Beadle (October 22, 1903 – June 9, 1989) was an American geneticist. In 1958 he shared one-half of the Nobel Prize in Physiology or Medicine with Edward Tatum for their discovery of the role of genes in regulating biochemical events within cells. He served as the 7th president of the University of Chicago from 1961 to 1968. Beadle and Tatum's key experiments involved exposing the bread mold ''Neurospora crassa'' to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments led them to propose a direct link between genes and enzymatic reactions, known as the One gene-one enzyme hypothesis. Education and early life George Wells Beadle was born in Wahoo, Nebraska. He was the son of Chauncey Elmer Beadle and Hattie Albro, who owned and operated a farm nearby. George was educated at the Wahoo High School and might himself have become a farmer if one o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research
Research is creative and systematic work undertaken to increase the stock of knowledge. It involves the collection, organization, and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness to controlling sources of bias and error. These activities are characterized by accounting and controlling for biases. A research project may be an expansion of past work in the field. To test the validity of instruments, procedures, or experiments, research may replicate elements of prior projects or the project as a whole. The primary purposes of basic research (as opposed to applied research) are documentation, discovery, interpretation, and the research and development (R&D) of methods and systems for the advancement of human knowledge. Approaches to research depend on epistemologies, which vary considerably both within and between humanities and sciences. There are several forms of research: scientific, humanities, artistic, eco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theory
A theory is a systematic and rational form of abstract thinking about a phenomenon, or the conclusions derived from such thinking. It involves contemplative and logical reasoning, often supported by processes such as observation, experimentation, and research. Theories can be scientific, falling within the realm of empirical and testable knowledge, or they may belong to non-scientific disciplines, such as philosophy, art, or sociology. In some cases, theories may exist independently of any formal discipline. In modern science, the term "theory" refers to Scientific theory, scientific theories, a well-confirmed type of explanation of nature, made in a way Consistency, consistent with the scientific method, and fulfilling the Scientific theory#Characteristics of theories, criteria required by modern science. Such theories are described in such a way that scientific tests should be able to provide Empirical evidence, empirical support for it, or Empirical evidence, empirical contradi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenotype
In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology (physical form and structure), its developmental processes, its biochemical and physiological properties, and its behavior. An organism's phenotype results from two basic factors: the expression of an organism's genetic code (its genotype) and the influence of environmental factors. Both factors may interact, further affecting the phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called polymorphic. A well-documented example of polymorphism is Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and again in his 1982 book '' The Extended Phenotype'' suggested that one can regard bird nests and other built structures such as caddisfly larva cases and beaver dams ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Locus (genetics)
In genetics, a locus (: loci) is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. Each chromosome carries many genes, with each gene occupying a different position or locus; in humans, the total number of Human genome#Coding sequences (protein-coding genes), protein-coding genes in a complete haploid set of 23 chromosomes is estimated at 19,000–20,000. Genes may possess multiple variants known as alleles, and an allele may also be said to reside at a particular locus. Diploid and polyploid cells whose chromosomes have the same allele at a given locus are called homozygote, homozygous with respect to that locus, while those that have different alleles at a given locus are called heterozygote, heterozygous. The ordered list of loci known for a particular genome is called a gene map. Gene mapping is the process of determining the specific locus or loci responsible for producing a particular phenotype or biological trait. Association ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mechanism (biology)
In biology, a mechanism is a system of causally interacting parts and processes that produce one or more effects. Phenomena can be explained by describing their mechanisms. For example, natural selection is a mechanism of evolution; other mechanisms of evolution include genetic drift, mutation, and gene flow. In ecology, mechanisms such as predation and host-parasite interactions produce change in ecological systems. In practice, no description of a mechanism is ever complete because not all details of the parts and processes of a mechanism are fully known. For example, natural selection is a mechanism of evolution that includes countless, inter-individual interactions with other individuals, components, and processes of the environment in which natural selection operates. Characterizations/ definitions Many characterizations/definitions of mechanisms in the philosophy of science/biology have been provided in the past decades. For example, one influential characterization of neu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Grüneberg
Hans Grüneberg (26 May 1907 – 23 October 1982), whose name was also written as Hans Grueneberg and Hans Gruneberg, was a British geneticist. Grüneberg was born in Wuppertal–Elberfeld in Germany. He obtained an MD from the University of Bonn, a PhD in biology from the University of Berlin and a DSc from the University of London. He arrived in London in 1933, at the invitation of J.B.S. Haldane and Sir Henry Dale. He was elected a Fellow of the Royal Society in 1956. Most of his work focused on mouse genetics, in which his speciality was the study of pleiotropic effects of mutations on the development of the mouse skeleton. He was the first person to describe siderocytes and sideroblasts, atypical nucleated erythrocytes with granules of iron accumulated in perinuclear mitochondria. This he reported in the journal ''Nature''. The Grüneberg ganglion, an olfactory ganglion in rodents, was first described by Hans Grueneberg in 1973. Career * Honorary Research Assistant, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
