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Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic ...
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PPARg RXRa 3E00
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the ''PPARG'' gene. Tissue distribution PPARG is mainly present in adipose tissue, colon and macrophages. Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 (found in nearly all tissues except muscle) and PPAR-γ2 (mostly found in adipose tissue and the intestine). Gene expression This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: peroxisome proliferator-activated receptor alpha, PPAR-alpha, peroxisome proliferator-activated receptor delta, PPAR-delta, ...
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Genomic
Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of ''individual'' genes and their roles in inheritance, genomics aims at the collective characterization and quantification of ''all'' of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advanc ...
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Nematostella Vectensis
The starlet sea anemone (''Nematostella vectensis'') is a species of small sea anemone in the family Edwardsiidae native to the east coast of the United States, with introduced populations along the coast of southeast England and the west coast of the United States (class ''Anthozoa'', phylum ''Cnidaria'', a sister group of Bilateria). Populations have also been located in Nova Scotia, Canada. This sea anemone is found in the shallow brackish water of coastal lagoons and salt marshes where its slender column is usually buried in the mud and its tentacles exposed. Its genome has been sequenced and it is cultivated in the laboratory as a model organism, but the IUCN has listed it as being a "Vulnerable species" in the wild. Description The starlet sea anemone has a bulbous basal end and a contracting column that ranges in length from less than . There is a fairly distinct division between the scapus, the main part of the column, and the capitulum, the part just below the crown of t ...
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Cnidarian
Cnidaria ( ) is a phylum under kingdom Animalia containing over 11,000 species of aquatic invertebrates found both in fresh water, freshwater and marine environments (predominantly the latter), including jellyfish, hydroid (zoology), hydroids, sea anemones, corals and some of the smallest marine parasites. Their distinguishing features are an uncentralized nervous system distributed throughout a gelatinous body and the presence of cnidocytes or cnidoblasts, specialized cells with ejectable flagella used mainly for envenomation and capturing prey. Their bodies consist of mesoglea, a non-living, jelly-like substance, sandwiched between two layers of epithelium that are mostly one cell (biology), cell thick. Cnidarians are also some of the few animals that can reproduce both sexually and asexually. Cnidarians mostly have two basic body forms: swimming medusa (biology), medusae and sessility (motility), sessile polyp (zoology), polyps, both of which are radially symmetrical with mou ...
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Trichoplax Adhaerens
''Trichoplax adhaerens'' is one of the four named species in the phylum Placozoa. The others are ''Hoilungia hongkongensis'', ''Polyplacotoma mediterranea'' and ''Cladtertia collaboinventa''. Placozoa is a basal group of multicellular animals, possible relatives of Cnidaria. ''Trichoplax'' are very flat organisms commonly less than 4 mm in diameter, lacking any Organ (anatomy), organs or internal structures. They have two cellular layers: the top epitheloid layer is made of ciliated "cover cells" flattened toward the outside of the organism, and the bottom layer is made up of cylinder cells that possess Cilium, cilia used in locomotion, and gland cells that lack cilia. Between these layers is the fibre syncytium, a liquid-filled cavity strutted open by star-like fibres. ''Trichoplax'' feed by absorbing food particles—mainly microbes—with their underside. They generally Asexual reproduction, reproduce asexually, by Cell division, dividing or budding, but can also Sexual r ...
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Placozoa
Placozoa ( ; ) is a phylum of free-living (non-parasitic) marine invertebrates. They are blob-like animals composed of aggregations of cells. Moving in water by ciliary motion, eating food by Phagocytosis, engulfment, reproducing by Fission (biology), fission or budding, placozoans are described as "the simplest animals on Earth." Structural and molecular analyses have supported them as among the most basal animals, thus, constituting a primitive metazoan phylum. The first known placozoan, ''Trichoplax adhaerens'', was discovered in 1883 by the German zoologist Franz Eilhard Schulze (1840–1921).F. E. Schulze "''Trichoplax adhaerens'' n. g., n. s.", ''Zoologischer Anzeiger'' (Elsevier, Amsterdam and Jena) 6 (1883), p. 92. Describing the uniqueness, another German, Karl Gottlieb Grell (1912–1994), erected a new phylum, Placozoa, for it in 1971. Remaining a monotypic phylum for over a century, new species began to be added since 2018. So far, three other extant species have been ...
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Mnemiopsis Leidyi
''Mnemiopsis leidyi'', the warty comb jelly or sea walnut, is a species of Tentaculata, tentaculate ctenophore (comb jelly). It is native to western Atlantic coastal waters, but has become established as an invasive species in European and western Asian regions. Three species have been named in the genus ''Mnemiopsis'', but they are now believed to be different ecological form (zoology), forms of a single species ''M. leidyi'' by most zoologists. Description and ecology ''Mnemiopsis'' have an oval-shaped and transparent lobed body, with four rows of ciliated combs that run along the body vertically and glow blue-green when disturbed. They have several feeding tentacles. Unlike cnidarians, ''Mnemiopsis'' does not sting. Their body comprises 97% water. They have a maximum body length of roughly and a diameter of . It is wikt:euryoecious, euryoecious, tolerating a wide range of salinity (2 to 38 Practical Salinity Unit, psu), temperature (), and water quality. ''Mnemiopsis'' is a ...
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Ctenophore
Ctenophora (; : ctenophore ) is a phylum of marine invertebrates, commonly known as comb jellies, that inhabit sea waters worldwide. They are notable for the groups of cilia they use for swimming (commonly referred to as "combs"), and they are the largest animals to swim with the help of cilia. Depending on the species, adult ctenophores range from a few millimeters to in size. 186 living species are recognised. Their bodies consist of a mass of jelly, with a layer two cells thick on the outside, and another lining the internal cavity. The phylum has a wide range of body forms, including the egg-shaped cydippids with a pair of retractable tentacles that capture prey, the flat, generally combless platyctenids, and the large-mouthed beroids, which prey on other ctenophores. Almost all ctenophores function as predators, taking prey ranging from microscopic larvae and rotifers to the adults of small crustaceans; the exceptions are juveniles of two species, which live ...
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Amphimedon Queenslandica
''Amphimedon queenslandica'' (formerly known as ''Reniera'' sp.) is a sponge native to the Great Barrier Reef. Its genome has been sequenced. It has been the subject of various studies on the evolution of metazoan development. ''A. queenslandica'' was first discovered in 1998 on Heron Island Reef by Sally Leys when looking for sponges with larvae to study polarity, and was formally described by John Hooper and Rob van Soest in 2006. Like most sponges it has a biphasic life cycle, passing through a planktonic phase whilst a larva, but later becoming a benthic dweller. It is hermaphroditic, and reproduces via spermcast spawning, meaning it releases sperm into water but retains eggs, which are fertilised internally. The embryos develop in brood chambers until they reach a certain size, then disperse as parenchymella larvae. During this larval stage, they have a strong preference for darkness. The sponge is difficult or impossible to maintain in captivity. Genetics The genome ...
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Sponge
Sponges or sea sponges are primarily marine invertebrates of the animal phylum Porifera (; meaning 'pore bearer'), a basal clade and a sister taxon of the diploblasts. They are sessile filter feeders that are bound to the seabed, and are one of the most ancient members of macrobenthos, with many historical species being important reef-building organisms. Sponges are multicellular organisms consisting of jelly-like mesohyl sandwiched between two thin layers of cells, and usually have tube-like bodies full of pores and channels that allow water to circulate through them. They have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. They do not have complex nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes, usually via flagella movements of the so-called " collar ...
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Fungi
A fungus (: fungi , , , or ; or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and mold (fungus), molds, as well as the more familiar mushrooms. These organisms are classified as one of the kingdom (biology)#Six kingdoms (1998), traditional eukaryotic kingdoms, along with Animalia, Plantae, and either Protista or Protozoa and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of motility, mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related o ...
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Algae
Algae ( , ; : alga ) is an informal term for any organisms of a large and diverse group of photosynthesis, photosynthetic organisms that are not plants, and includes species from multiple distinct clades. Such organisms range from unicellular microalgae, such as cyanobacteria, ''Chlorella'', and diatoms, to multicellular macroalgae such as kelp or brown algae which may grow up to in length. Most algae are aquatic organisms and lack many of the distinct cell and tissue types, such as stomata, xylem, and phloem that are found in embryophyte, land plants. The largest and most complex marine algae are called seaweeds. In contrast, the most complex freshwater forms are the Charophyta, a Division (taxonomy), division of green algae which includes, for example, ''Spirogyra'' and stoneworts. Algae that are carried passively by water are plankton, specifically phytoplankton. Algae constitute a Polyphyly, polyphyletic group because they do not include a common ancestor, and although Eu ...
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