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Mariner-like Elements
Tc1/mariner is a class and superfamily of interspersed repeats DNA (Class II) transposons. The elements of this class are found in all animals, including humans. They can also be found in protists and bacteria. The class is named after its two best-studied members, the Tc1 transposon of ''Caenorhabditis elegans'' and the mariner transposon of ''Drosophila''. Structure The transposon consists of a transposase gene, flanked by two terminal inverted repeats (TIR). Two short tandem site duplications (TSD) are present on both sides of the insert. Transposition happens when two transposases recognize and bind to TIR sequences, join together and promote DNA double-strand cleavage. The DNA-transposase complex then inserts its DNA cargo at specific DNA motifs elsewhere in the genome, creating short TSDs upon integration. In the IS630/Tc1/mariner system, the motif used is a "TA" dinucleotide, duplicated on both ends after insertion. When the transposase gene is not carried by the tran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sleeping Beauty Transposon System
The ''Sleeping Beauty'' transposon system is a synthetic DNA transposon designed to introduce precisely defined DNA sequences into the chromosomes of vertebrate animals for the purposes of introducing new traits and to discover new genes and their functions. It is a Tc1/mariner-type system, with the transposase resurrected from multiple inactive fish sequences. Mechanism of action The ''Sleeping Beauty'' transposon system is composed of a ''Sleeping Beauty'' (SB) transposase and a transposon that was designed in 1997 to insert specific sequences of DNA into genomes of vertebrate animals. DNA transposons translocate from one DNA site to another in a simple, cut-and-paste manner (Fig. 1). Transposition is a precise process in which a defined DNA segment is excised from one DNA molecule and moved to another site in the same or different DNA molecule or genome. As do all other Tc1/mariner-type transposases, SB transposase inserts a transposon into a TA dinucleotide base pair ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ceratitis Rosa
''Ceratitis rosa'', the Natal fruit fly or Natal fly, a species from the family Tephritidae of the order Diptera, is a fruit fly. It was described in 1887 from specimens of Delagoa Bay, Mozambique Mozambique (), officially the Republic of Mozambique ( pt, Moçambique or , ; ny, Mozambiki; sw, Msumbiji; ts, Muzambhiki), is a country located in southeastern Africa bordered by the Indian Ocean to the east, Tanzania to the north, Malawi .... Morphology Adult flies grow up to 4 to 7 mm long and usually have banded wings, with yellow and black patterns. Distribution The polyphagous African species known distribution is mainly southern and eastern Africa especially in Angola, DRC, Eswatini, Ethiopia, Kenya, Malawi, Mali, Mozambique, Nigeria, Rwanda, South Africa (KwaZulu-Natal), Tanzania, Uganda, Zimbabwe, and the islands of Mauritius and Reunion. Host In various regions of Africa, the pest is observed in over 100 species, of which, it is mostly found affecting arabica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
POGZ
Pogo transposable element with ZNF domain is a protein that in humans is encoded by the ''POGZ'' gene. The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. At least three alternatively spliced transcript variants encoding distinct isoforms A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some isof ... have been observed. Clinical significance Heterozygous mutation of POGZ causes White-Sutton syndrome. References Further reading * * * * * * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JRK (gene)
Joseph Rao Kony (likely born 1961) is a Ugandan militant who founded the Lord's Resistance Army (LRA), a Christian fundamentalist organization, designated as a terrorist group by the United Nations Peacekeepers, the European Union and various other governments. An Acholi, Kony was born into a middle-class family. Kony's father Luizi Obol and his mother Nora Oting were both farmers. Kony dropped out of school at a young age. In 1987, he formed the Lord's Resistance Army. Kony declared a military offensive in Uganda, aiming to overthrow Yoweri Museveni's Ugandan government and establish a theocratic state based on the dominion theology. After Kony's terror activities, he was banished from Uganda, and shifted to South Sudan. Kony described himself as a freedom fighter, struggling for a Christian Uganda. Kony has long been one of Africa's most notorious warlords. He is currently one of the most wanted African militants as well. He has been accused by government entities of orde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
