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Magellanine
(−)-Magellanine is a member of the '' Lycopodium'' alkaloid class of natural products. It was isolated from the club moss '' Lycopodium magellanicum'' in 1976. It has been synthesized five times, with the first synthesis having been completed by the Larry E. Overman group at the University of California, Irvine in 1993. It has also been synthesized by the Leo Paquette group in 1993 at Ohio State University, the Chun-Chen Liao group in 2002 at National Tsing Hua University, the Miyuki Ishikazi and Tamiko Takahashi groups in 2005 at the Josai International University and Tokyo University of Science, and the Chisato Mukai group in 2007 at the Kanazawa University. One partial synthesis was completed by the A. I. Meyers group in 1995 at Colorado State University. Biosynthetically, it is thought to have been derived from lysine Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. It contains an α-amino group (which is in the protonated form und ...
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Lycopodium Magellanicum
''Austrolycopodium magellanicum'', synonym ''Lycopodium magellanicum'', the Magellanic clubmoss, is a species of vascular plant in the club moss family Lycopodiaceae. The genus ''Austrolycopodium'' is accepted in the Pteridophyte Phylogeny Group classification of 2016 (PPG I), but not in other classifications which submerge the genus in '' Lycopodium''. The species grows in the mountains of Latin America from Costa Rica and the Dominican Republic south as far as Tierra del Fuego, as well as a number of islands in the antarctic and subantarctic oceans (Tristan da Cunha, Gough Island, Amsterdam Island, South Georgia and the South Sandwich Islands, Falkland Islands, Juan Fernández Islands, Marion Island, Prince Edward Islands, Iles Crozet, Iles Kerguelen). A number of natural products have been isolated from this plant, including magellanine, magellaninone, panticuline, acetyldihydrolycopodine, acetylfawcettiine, clavolonine (8b-hydroxylycopodine), deacetylfawcettiine, f ...
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Lycopodium
''Lycopodium'' (from Greek ''lykos'', wolf and ''podion'', diminutive of ''pous'', foot) is a genus of clubmosses, also known as ground pines or creeping cedars, in the family Lycopodiaceae. Two very different circumscriptions of the genus are in use. In the Pteridophyte Phylogeny Group classification of 2016 (PPG I), ''Lycopodium'' is one of nine genera in the subfamily Lycopodioideae, and has from nine to 15 species. In other classifications, the genus is equivalent to the whole of the subfamily, since it includes all of the other genera. More than 40 species are accepted. Description They are flowerless, vascular, terrestrial or epiphytic plants, with widely branched, erect, prostrate, or creeping stems, with small, simple, needle-like or scale-like leaves that cover the stem and branches thickly. The leaves contain a single, unbranched vascular strand, and are microphylls by definition. The kidney-shaped (reniform) spore-cases (sporangia) contain spores of one kind only, ...
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Alkaloid
Alkaloids are a class of basic BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Thomas E. Kurtz at Dartmouth College ..., natural product, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms includi ...
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Chemical Synthesis
As a topic of chemistry, chemical synthesis (or combination) is the artificial execution of chemical reactions to obtain one or several products. This occurs by physical and chemical manipulations usually involving one or more reactions. In modern laboratory uses, the process is reproducible and reliable. A chemical synthesis involves one or more compounds (known as ''reagents'' or ''reactants'') that will experience a transformation when subjected to certain conditions. Various reaction types can be applied to formulate a desired product. This requires mixing the compounds in a reaction vessel, such as a chemical reactor or a simple round-bottom flask. Many reactions require some form of processing ("work-up") or purification procedure to isolate the final product. The amount produced by chemical synthesis is known as the ''reaction yield''. Typically, yields are expressed as a mass in grams (in a laboratory setting) or as a percentage of the total theoretical quanti ...
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Larry E
Larry is a masculine given name in English, derived from Lawrence or Laurence. It can be a shortened form of those names. Larry may refer to the following: People Arts and entertainment *Larry D. Alexander, American artist/writer * Larry Boone, American country singer * Larry Collins, American musician, member of the rockabilly sibling duo The Collins Kids * Larry David (born 1947), Emmy-winning American actor, writer, comedian, producer and film director * Larry Emdur, Australian TV host * Larry Feign, American cartoonist working in Hong Kong * Larry Fine, of the Three Stooges * Larry Gates, American actor * Larry Gatlin, American country singer * Larry Gelbart (1928–2009), American screenwriter, playwright, director and author * Larry Graham, founder of American funk band Graham Central Station * Larry Hagman, American actor, best known for the TV series ''I Dream of Jeannie'' and ''Dallas'' * Larry Henley (1937–2014), American singer and songwriter, member of The Newb ...
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University Of California, Irvine
The University of California, Irvine (UCI or UC Irvine) is a public land-grant research university in Irvine, California. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and professional degrees, and roughly 30,000 undergraduates and 6,000 graduate students are enrolled at UCI as of Fall 2019. The university is classified among " R1: Doctoral Universities – Very high research activity", and had $436.6 million in research and development expenditures in 2018. UCI became a member of the Association of American Universities in 1996. The university was rated as one of the " Public Ivies” in 1985 and 2001 surveys comparing publicly funded universities the authors claimed provide an education comparable to the Ivy League. The university also administers the UC Irvine Medical Center, a large teaching hospital in Orange, and its affiliated health sciences system; the University of California, Irvine, Arboretum; ...
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Leo Paquette
Leo Armand Paquette ( – January 21, 2019) was an American organic chemist. Biography He was born on July 15, 1934 to parents Armand and Clarice with roots in Quebec (great-grandfather Edmund was born in Contrecoeur, Quebec) and he received his B.S. degree from Holy Cross College in 1956 and his Ph.D. in Organic Chemistry from the Massachusetts Institute of Technology in 1959 with Professor Norman Allan Nelson. After serving as a research associate at the Upjohn Company from 1959 to 1963, he joined the faculty of Ohio State University. He was promoted to full professor in 1969 and was named Distinguished University Professor in 1987. Paquette was elected a member of the National Academy of Sciences in 1984, and was the founding editor of the '' Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). Paquette is perhaps best known for achieving the first total synthesis of the Platonic solid dodecahedrane. Scientific misconduct In 1993, an Ohio State University i ...
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Ohio State University
The Ohio State University, commonly called Ohio State or OSU, is a public land-grant research university in Columbus, Ohio. A member of the University System of Ohio, it has been ranked by major institutional rankings among the best public universities in the United States. Founded in 1870 as the state's land-grant university and the ninth university in Ohio with the Morrill Act of 1862, Ohio State was originally known as the Ohio Agricultural and Mechanical College and focused on various agricultural and mechanical disciplines, but it developed into a comprehensive university under the direction of then-Governor and later U.S. president Rutherford B. Hayes, and in 1878, the Ohio General Assembly passed a law changing the name to "the Ohio State University" and broadening the scope of the university. Admission standards tightened and became greatly more selective throughout the 2000s and 2010s. Ohio State's political science department and faculty have greatly con ...
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National Tsing Hua University
National Tsing Hua University (NTHU; ) is a public research university in Hsinchu City, Taiwan. National Tsing Hua University was first founded in Beijing. After the Chinese Civil War, the then-president of the university, Mei Yiqi, and other major academics fled to Taiwan with the retreating Nationalist government. In 1956, they reinstalled National Tsing Hua University in Hsinchu, Taiwan, which has since remained independent and distinct from Tsinghua University in Beijing. National Tsing Hua University is one of the six national research universities in Taiwan, and it is consistently ranked among the top three best universities in Taiwan in world university rankings. In the 2022 QS World University Rankings, it is ranked within the top 200 universities in the world and the top 50 universities in Asia. The university is part of a leading research and innovation cluster in Taiwan, along with nearby National Yang Ming Chiao Tung University, National Space Organization, N ...
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Josai International University
, JIU, is a private university established in 1992, with two campuses, one in Tōgane, Chiba Prefecture, Japan, and one in Kioi-chō, Chiyoda-ku is a special ward located in central Tokyo, Japan. It is known as Chiyoda City in English.Profil ...
, and a smaller learning center in Awa Kamogawa. Undergraduate programs include International Humanities, Japanese Language, Management and Information Science, Media Studies, Nursing, Pharmaceutical Sciences, Social and Environmental Studies, Social Work Studies, and Tourism. Graduate programs offer degrees in Humanities (M.A. in Women's Studies / Inter-Cultural Studies / Global Communication; Ph.D. in Comparative Cultures), Management and Information Sciences (MBA and Ph.D. in M ...
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Tokyo University Of Science
, formerly "Science University of Tokyo" or TUS, informally or simply is a private research university located in Shinjuku, Tokyo, Japan. History Tokyo University of Science was founded in 1881 as The Tokyo Academy of Physics by 21 graduates of the Department of Physics in the Faculty of Science, University of Tokyo (then the Imperial University). In 1883, it was renamed the Tokyo College of Science, and in 1949, it attained university status and became the Tokyo University of Science. The leading character appearing in Japanese novelist Soseki Natsume's novel Botchan graduated from Tokyo University of Science. , it is the only private university in Japan that has produced a Nobel Prize winner and the only private university in Asia to produce Nobel Prize winners within the natural sciences field. Academic rankings Global university rankings Academic Ranking of World Universities ranked Tokyo University of Science in equal 13th place in Japan. Graduate school rankings ...
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Kanazawa University
Kanazawa University ( ja, 金沢大学, Kanazawa Daigaku, abbreviated to ja, 金大, Kindai) is a Japanese national university in the city of Kanazawa, the capital of Ishikawa Prefecture. Founded in 1862, it was chartered as a university in 1949. Kanazawa University is divided into two main campuses: Kakuma and Takaramachi. University enrollment is about 10,100 students, including 636 international students in 2021. History The university was founded in 1862 as an institution for smallpox vaccination (種痘 所, Shutō-sho ) called which was established by the Kaga Domain. In 1876 it became a medical school from Ishikawa Prefecture. In 1887 it became the Medical Faculty of the State Fourth Higher Middle School (第四 高等 中 学校 医学 部, Dai-shi kōtō chūgakkō igakubu ) and then in 1894 to the Medical Faculty of the State Fourth High School (第四 高等学校 医学 部, Dai-shi kōtō gakkō igakubu ). In 1901 it developed into the Kanazawa Medical Coll ...
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