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Lorenzo's Oil
''Lorenzo's Oil'' is a 1992 drama film directed and co-written by George Miller. It is based on the true story of Augusto and Michaela Odone, parents who search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD), leading to the development of Lorenzo's oil. The film was shot in Pittsburgh, Pennsylvania, primarily from September 1991 to February 1992. It had a limited release in North America on December 30, 1992, with a nationwide release two weeks later, on January 15, 1993. Though it was a box office disappointment, grossing $7.2 million against its $30 million budget, the film was generally well received by critics and garnered two nominations at the 65th Academy Awards. Plot Lorenzo is a bright and vibrant young boy living in the Comoro Islands, as his father Augusto Odone works for the World Bank and is stationed there. However, after relocating with his parents to the United States, he begins to show signs of neurological problems (such as falling, los ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Miller (filmmaker)
George Miller (born 3 March 1945) is an Australian filmmaker. Over the course of four decades he has received critical and popular success, and is widely known for creating and directing every film in the Mad Max, ''Mad Max'' franchise starting in 1979, including two entries which are considered List of films considered the best#Action, two of the greatest action films of all time according to Metacritic. He has earned List of awards and nominations received by George Miller, numerous accolades including an Academy Award from six nominations in five different categories. His directing career started in Australia with the first three ''Mad Max'' films between 1979 and 1985 with his friend and producing partner Byron Kennedy, after which he transitioned to Hollywood with ''The Witches of Eastwick (film), The Witches of Eastwick'' (1987). His family drama ''Lorenzo's Oil'' (1992) earned him his first Academy Award nomination after which he produced and co-wrote ''Babe (film), Babe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pittsburgh, Pennsylvania
Pittsburgh ( ) is a city in Allegheny County, Pennsylvania, United States, and its county seat. It is the List of municipalities in Pennsylvania#Municipalities, second-most populous city in Pennsylvania (after Philadelphia) and the List of United States cities by population, 67th-most populous city in the U.S., with a population of 302,971 as of the 2020 United States census, 2020 census. The city is located in Western Pennsylvania, southwestern Pennsylvania at the confluence of the Allegheny River and Monongahela River, which combine to form the Ohio River. It anchors the Greater Pittsburgh, Pittsburgh metropolitan area, which had a population of 2.457 million residents and is the largest metro area in both the Ohio Valley and Appalachia, the Pennsylvania metropolitan areas, second-largest in Pennsylvania, and the List of metropolitan statistical areas, 26th-largest in the U.S. Pittsburgh is the principal city of the greater Pittsburgh–New Castle–Weirton combined statistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kathleen Wilhoite
Kathleen Wilhoite (born June 29, 1964) is an American actress and musician. She made her feature film debut in ''Private School'' (1983) before having a leading role in '' Murphy's Law'' (1986), followed by supporting parts in '' Witchboard'' (also 1986), '' Crossing Delancey'' (1988), '' Road House'' (1989), and ''Lorenzo's Oil'' (1992). She also had notable guest-starring roles on several series during this time, including ''Twin Peaks'' (1990). Beginning in 1994, Wilhoite appeared as Chloe Lewis in a recurring guest-starring role on the series '' ER'', and voiced the role of the titular character on the ABC animated series '' Pepper Ann'' (1997–2001). Other notable film roles during the 1990s include the science fiction thriller '' Fire in the Sky'' (1993), and the survival film '' The Edge'' (1997). In 2003, she was cast in a recurring role as Liz Danes on '' Gilmore Girls'', and has subsequently had guest-starring roles on '' Criminal Minds'' (2008), ''Grey's Anatomy'' ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hugo Moser (scientist)
Hugo Wolfgang Moser (1924–2007) was a Swiss-born American research scientist and director of the Neurogenetics Research Center at the Kennedy Krieger Institute. Moser was also University Professor of Neurology and Pediatrics at Johns Hopkins University. His research on peroxisomal disorders achieved international recognition. Early life Moser was born in Bern, Switzerland, the son of Maria and Hugo L. Moser. He grew up in Berlin. His father was of Jewish background and a prominent art dealer in Berlin. His mother was Austrian. Within a month of Hitler taking power in Germany the family left Berlin. Hugo spent his high school years in the Netherlands. Three months prior to the Battle of the Netherlands, invasion of the Netherlands his mother arranged their timely escape from the Nazis. The family fled via Italy and Spain to Cuba. In 1940, the family arrived in the US, first living in Baltimore, where the family owned paintings exhibited in the Baltimore Museum of Art, then mov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Myelin Project
The Myelin Project was a 501(c)(3) nonprofit organization established in 1989 by Augusto Odone and his wife, Michaela and their friend Patti Chapman. Their son, Lorenzo, suffered from adrenoleukodystrophy (ALD), the most common of the leukodystrophies. The story of the Odones' struggle was dramatized in the 1992 Hollywood film ''Lorenzo's Oil'', starring actors Nick Nolte, Susan Sarandon and Peter Ustinov. After 20 years, the Myelin Project was merged into another organization called ALD Connect in July 2019. The Myelin Project had three branches, in the United States, Germany, and the United Kingdom. Its scientific advisory committee included researchers from Yale University and the University of Wisconsin–Madison in the United States, the Istituto Superiore di Sanità and San Raffaele Hospital in Italy, the Hôpital de la Salpêtrière and the Institute Pasteur in France, Queen's University at Kingston in Canada, the University of Cambridge and University of Edinburg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid
Lipids are a broad group of organic compounds which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. Lipids have applications in the cosmetic and food industries, and in nanotechnology. Lipids are broadly defined as hydrophobic or amphiphilic small molecules; the amphiphilic nature of some lipids allows them to form structures such as vesicles, multilamellar/ unilamellar liposomes, or membranes in an aqueous environment. Biological lipids originate entirely or in part from two distinct types of biochemical subunits or "building-blocks": ketoacyl and isoprene groups. Using this approach, lipids may be divided into eight categories: fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myelin Sheath
Myelin Sheath ( ) is a lipid-rich material that in most vertebrates surrounds the axons of neurons to insulate them and increase the rate at which electrical impulses (called action potentials) pass along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Myelin ensheaths part of an axon known as an internodal segment, in multiple myelin layers of a tightly regulated internodal length. The ensheathed segments are separated at regular short unmyelinated intervals, called nodes of Ranvier. Each node of Ranvier is around one micrometre long. Nodes of Ranvier enable a much faster rate of conduction known as saltatory conduction where the action potential recharges at each node to jump over to the next node, and so on till it reaches the axon terminal. At the terminal the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olive Oil
Olive oil is a vegetable oil obtained by pressing whole olives (the fruit of ''Olea europaea'', a traditional Tree fruit, tree crop of the Mediterranean Basin) and extracting the oil. It is commonly used in cooking for frying foods, as a condiment, or as a salad dressing. It can also be found in some cosmetics, pharmaceuticals, soaps, and fuels for traditional oil lamps. It also has additional uses in some religions. The olive is one of three core food plants in Mediterranean cuisine, with wheat and grapes. Olive trees have been cultivated around the Mediterranean since the 8th millennium BC. In 2022, Spain was the world's largest producer, manufacturing 24% of the world's total. Other large producers were Italy, Greece, and Turkey, collectively accounting for 59% of the global market. The composition of olive oil varies with the cultivar, altitude, time of harvest, and extraction process. It consists mainly of oleic acid (up to 83%), with smaller amounts of other fatty acids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rapeseed Oil
Close-up of canola blooms Canola flower Rapeseed oil is one of the oldest known vegetable oils. There are both edible and industrial forms produced from rapeseed, the seed of several cultivars of the plant family Brassicaceae. Historically, it was restricted as a food oil due to its content of erucic acid. Laboratory studies about this acid have shown damage to the cardiac muscle of laboratory animals in high quantities. It also imparts a bitter taste, and glucosinolates, which made many parts of the plant less nutritious in animal feed. Rapeseed oil from standard cultivars can contain up to 54% erucic acid. Canola oil is a food-grade version derived from rapeseed cultivars specifically bred for low acid content. It is also known as low erucic acid rapeseed (LEAR) oil and is generally recognized as safe by the United States Food and Drug Administration.ecfr.gov version Canola oil is limited by government regulation to a maximum of 2% erucic acid by weight in the US a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Long Chain Fatty Acids
In chemistry, in particular in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, from 4 to 28. Fatty acids are a major component of the lipids (up to 70% by weight) in some species such as microalgae but in some other organisms are not found in their standalone form, but instead exist as three main classes of esters: triglycerides, phospholipids, and cholesteryl esters. In any of these forms, fatty acids are both important dietary sources of fuel for animals and important structural components for cells. History The concept of fatty acid (''acide gras'') was introduced in 1813 by Michel Eugène Chevreul, though he initially used some variant terms: ''graisse acide'' and ''acide huileux'' ("acid fat" and "oily acid"). Types of fatty acids Fatty acids are classified in many ways: by length, by saturation vs unsaturati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Croda International
Croda International plc is a British speciality chemicals company based at Snaith, England. It is listed on the London Stock Exchange. History The company was founded by George William Crowe and Henry James Dawe in 1925. Crowe bought an abandoned waterworks facility at Rawcliffe Bridge for £7, which would later be used to manufacture the company's first barrels of lanolin, a natural protective fat present in sheep's wool. The company was named ''Croda (''a combination of the first few letters of his surname with that of his partner, Dawe). Crowe and Dawe began working on a process to extract lanolin from sheep’s wool for various industries, including uses in cosmetics, as a waterproofing agent, and as a dressing for leather. At the time, the UK imported lanolin, having no domestic lanolin production at all. Dawe's extraction process failed initially and Dawe left the company. Philip Wood, Crowe's nephew, was appointed manager of the site in 1925, and Wood worked clos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erucic Acid
Erucic acid is a monounsaturated omega-9 fatty acid, denoted 22:1ω9. It has the chemical formula: . It is prevalent in wallflower seed and other plants in the family Brassicaceae, with a reported content of 20 to 54% in high erucic acid rapeseed oil and 42% in mustard oil. Erucic acid is also known as ''cis''-13-docosenoic acid and the trans isomer is known as brassidic acid. Cetoleic acid is a positional isomer of erucic acid. Uses Erucic acid is a precursor to brassylic acid, a C13-dicarboxylic acid that is used to make specialty polyamides and polyesters. The conversion entails ozonolysis, which selectively cleaves the C=C bond in erucic acid: CH3(CH2)7CH\dCH(CH2)11CO2H + O3 + 0.5 O2 -> CH3(CH2)7CO2H + HO2C(CH2)11CO2H Amides of erucic acid are used as lubricants and surfactants. Hydrogenation of erucic acid gives behenyl alcohol, , a pour point depressant (enabling liquids to flow at a lower temperature), and silver behenate, for use in photography. Sour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
