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Legionnaires' Disease
Legionnaires' disease is a form of atypical pneumonia caused by any species of ''Legionella'' bacteria, quite often ''Legionella pneumophila''. Signs and symptoms include cough, shortness of breath, high fever, myalgia, muscle pains, and headaches. Nausea, vomiting, and diarrhea may also occur. This often begins 2–10 days after exposure. A legionellosis is any disease caused by ''Legionella'', including Legionnaires' disease (a pneumonia) and Pontiac fever (a related upper respiratory tract infection), but Legionnaires' disease is the most common, so mentions of legionellosis often refer to Legionnaires' disease. The bacterium is found naturally in fresh water. It can contaminate hot water tanks, hot tubs, and cooling towers of large air conditioners. It is usually spread by breathing in mist that contains the bacteria. It can also occur when contaminated water is Pulmonary aspiration, aspirated. It typically does not spread directly between people, and most people who are ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infectious Disease
An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an Disease#Terminology, illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently pathogenic bacteria, bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an Innate immune system, innate response, often involving inflammation, followed by an Adaptive immune system, adaptive response. Treatment for infections depends on the type of pathogen involved. Common medications include: * Antibiotics for bacterial infections. * Antivirals for viral infections. * Antifungals for fungal infections. * Antiprotozoals for protozoan infections. * Antihelminthics for infections caused by parasi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pontiac Fever
Pontiac fever is an acute, nonfatal respiratory disease caused by various species of Gram-negative bacteria in the genus ''Legionella''. It causes a mild upper respiratory infection that resembles acute influenza. Pontiac fever resolves spontaneously and often goes undiagnosed. Both Pontiac fever and the more severe Legionnaire's disease may be caused by the same bacterium, but Pontiac fever does not include pneumonia. Signs and symptoms Cause Species of ''Legionella'' known to cause Pontiac fever include ''Legionella pneumophila'', '' Legionella longbeachae'', '' Legionella feeleii'', '' Legionella micdadei'', and '' Legionella anisa''. Sources of the causative agents are aquatic systems and potting soil. The first outbreak caused by inhalation of aerosolized potting soil was discovered in New Zealand in January 2007. A total of 10 workers at a nursery came down with Pontiac fever. It was the first identification of ''L. longbeachae''. Pontiac fever does not spread from perso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philadelphia
Philadelphia ( ), colloquially referred to as Philly, is the List of municipalities in Pennsylvania, most populous city in the U.S. state of Pennsylvania and the List of United States cities by population, sixth-most populous city in the United States, with a population of 1,603,797 in the 2020 United States census, 2020 census. The city is the urban core of the Philadelphia metropolitan area (sometimes called the Delaware Valley), the nation's Metropolitan statistical area, seventh-largest metropolitan area and ninth-largest combined statistical area with 6.245 million residents and 7.379 million residents, respectively. Philadelphia was founded in 1682 by William Penn, an English Americans, English Quakers, Quaker and advocate of Freedom of religion, religious freedom, and served as the capital of the Colonial history of the United States, colonial era Province of Pennsylvania. It then played a historic and vital role during the American Revolution and American Revolutionary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Legion
The American Legion, commonly known as the Legion, is an Voluntary association, organization of United States, U.S. war veterans headquartered in Indianapolis, Indiana. It comprises U.S. state, state, Territories of the United States, U.S. territory, and overseas departments, in turn made up of local posts. It was established in March 1919 in Paris, France, by Officer (armed forces), officers and men of the American Expeditionary Forces (A.E.F.). It was subsequently chartered by the 66th United States Congress, 66th U.S. Congress on September 16, 1919. The Legion played the leading role in drafting and passing the Servicemen's Readjustment Act of 1944, commonly known as the "G.I. Bill". In addition to organizing commemorative events, members assist at Department of Veterans Affairs (VA) List of Veterans Affairs medical facilities, hospitals and clinics. It is active in issue-oriented U.S. politics. Its primary political activity is Lobbying in the United States, lobbying on beha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1976 Philadelphia Legionnaires' Disease Outbreak
The 1976 Legionnaires' disease outbreak, occurring in the late summer in Philadelphia, Pennsylvania, United States at an annual American Legion convention, was the first occasion in which a Disease cluster, cluster of a particular type of pneumonia cases were determined to be caused by the ''Legionella pneumophila'' bacteria. Previous outbreaks were retroactively diagnosed as being most probably caused by Legionella bacteria. Background On July 21, 1976, the American Legion opened its annual three-day convention at the Bellevue-Stratford Hotel in Philadelphia, Pennsylvania. More than 2,000 Legionnaires, mostly men, attended the convention. The date and city were chosen to coincide with America's celebration of the United States Bicentennial, 200th anniversary of the signing of the US Declaration of Independence at Philadelphia in 1776. On July 27, three days after the convention ended, Legionnaire Ray Brennan, a 61-year-old retired US Air Force Captain (United States O-3), cap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Outbreak
In epidemiology, an outbreak is a sudden increase in occurrences of a disease when cases are in excess of normal expectancy for the location or season. It may affect a small and localized group or impact upon thousands of people across an entire continent. The number of cases varies according to the disease-causing agent, and the size and type of previous and existing exposure to the agent. Outbreaks include many epidemics, which term is normally only for infectious diseases, as well as diseases with an environmental origin, such as a water or foodborne disease. They may affect a region in a country or a group of countries. Pandemics are near-global disease outbreaks when multiple and various countries around the Earth are soon infected. Definition The terms "outbreak" and "epidemic" have often been used interchangeably. Researchers Manfred S. Green and colleagues propose that the latter term be restricted to larger events, pointing out that '' Chambers Concise Dictionary'' and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doxycycline
Doxycycline is a Broad-spectrum antibiotic, broad-spectrum antibiotic of the Tetracycline antibiotics, tetracycline class used in the treatment of infections caused by bacteria and certain parasites. It is used to treat pneumonia, bacterial pneumonia, acne vulgaris, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis. It is also used to prevent malaria. Doxycycline may be taken Oral administration, by mouth or by intravenous, injection into a vein. Common side effects include diarrhea, nausea, vomiting, abdominal pain, and an increased risk of sunburn. Use during pregnancy is not recommended. Like other agents of the tetracycline class, it either slows or kills bacteria by inhibiting protein production. It kills malaria by targeting a plastid organelle, the apicoplast. Doxycycline was patented in 1957 and came into commercial use in 1967. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. Doxycyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azithromycin
Azithromycin, sold under the brand names Zithromax (in oral form) and Azasite (as an eye drop), is an antibiotic medication used for the treatment of several bacterial infections. This includes otitis media, middle ear infections, strep throat, pneumonia, traveler's diarrhea, Sexually transmitted infection, STI and certain other gastroenteritis, intestinal infections. Along with other medications, it may also be used for malaria. It is Drug administration, administered by mouth, intravenously, into a vein, or into the eye drops, eye. Common side effects include nausea, vomiting, diarrhea and upset stomach. An allergic reaction, such as anaphylaxis, or a type of diarrhea caused by Clostridioides difficile infection, ''Clostridioides difficile'' is possible. Azithromycin causes drug-induced QT prolongation, QT prolongation that may cause life-threatening arrhythmias such as torsades de pointes. While some studies claim that no harm has been found with use during pregnancy, more ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluoroquinolone
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. Quinolone antibiotics are classified into four generations based on their spectrum of activity and chemical modifications. The first-generation quinolones, such as nalidixic acid, primarily target Gram-negative bacteria and are mainly used for urinary tract infections. Second-generation quinolones introduced fluorine atoms into their structure, creating fluoroquinolones, which significantly expanded their antibacterial activity to include some Gram-positive bacteria. Third-generation fluoroquinolones further improved Gram-positive coverage, while fourth-generation fluoroquinolones offer broad-spectrum activity, including anaerobic bacteria. Only quinolone antibiotics in generati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, treatment and antibiotic prophylaxis, prevention of such infections. They may either bactericide, kill or bacteriostatic agent, inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek language, Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and recognize further and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylaxis, prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic vaccines, therapeutic (to fight a disease that has already occurred, such as cancer vaccine, cancer). Some vaccines offer full sterilizing immunity, in which infection is prevented. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pulmonary Aspiration
Pulmonary aspiration is the entry of solid or liquid material such as pharyngeal secretions, food, drink, or stomach contents from the oropharynx or gastrointestinal tract, into the trachea and lungs. When pulmonary aspiration occurs during eating and drinking, the aspirated material is often colloquially referred to as "going down the wrong pipe". Consequences of pulmonary aspiration include no injury at all, chemical pneumonitis, pneumonia, or even death from asphyxiation. These consequences depend on the volume, chemical composition, particle size, and presence of infectious agents in the aspirated material, and on the underlying health status of the person. In healthy people, aspiration of small quantities of material is common and rarely results in disease or injury. People with significant underlying disease or injury are at greater risk for developing respiratory complications following pulmonary aspiration, especially hospitalized patients, because of certain factors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
