Granulation (making Of Granules)
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Granulation (making Of Granules)
Granulation is the process of forming grains or granules from a powdery or solid substance, producing a granular material. It is applied in several technological processes in the chemical and pharmaceutical industries. Typically, granulation involves agglomeration of fine particles into larger granules, typically of size range between 0.2 and 4.0 mm depending on their subsequent use. Less commonly, it involves shredding or grinding solid material into finer granules or pellets. From powder The granulation process combines one or more powder particles and forms a granule that will allow tableting to be within required limits. It is the process of collecting particles together by creating bonds between them. Bonds are formed by compression or by using a binding agent. Granulation is extensively used in the pharmaceutical industry, for manufacturing of tablets and pellets. This way predictable and repeatable process is possible and granules of consistent quality can be produced ...
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Granularity
Granularity (also called graininess), the condition of existing in granules or grains, refers to the extent to which a material or system is composed of distinguishable pieces. It can either refer to the extent to which a larger entity is subdivided, or the extent to which groups of smaller indistinguishable entities have joined together to become larger distinguishable entities. Precision and ambiguity Coarse-grained materials or systems have fewer, larger discrete components than fine-grained materials or systems. * A coarse-grained description of a system regards large subcomponents. * A fine-grained description regards smaller components of which the larger ones are composed. The concepts granularity, coarseness, and fineness are relative; and are used when comparing systems or descriptions of systems. An example of increasingly fine granularity: a list of nations in the United Nations, a list of all states/provinces in those nations, a list of all cities in those states, ...
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Water
Water (chemical formula ) is an inorganic, transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's hydrosphere and the fluids of all known living organisms (in which it acts as a solvent). It is vital for all known forms of life, despite not providing food, energy or organic micronutrients. Its chemical formula, H2O, indicates that each of its molecules contains one oxygen and two hydrogen atoms, connected by covalent bonds. The hydrogen atoms are attached to the oxygen atom at an angle of 104.45°. "Water" is also the name of the liquid state of H2O at standard temperature and pressure. A number of natural states of water exist. It forms precipitation in the form of rain and aerosols in the form of fog. Clouds consist of suspended droplets of water and ice, its solid state. When finely divided, crystalline ice may precipitate in the form of snow. The gaseous state of water is steam or water vapor. Water co ...
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Plastic Recycling
Plastic recycling is the reprocessing of plastic waste into new products. When performed correctly, this can reduce dependence on landfill, conserve resources and protect the environment from plastic pollution and greenhouse gas emissions. Although recycling rates are increasing, they lag behind those of other recoverable materials, such as aluminium, glass and paper. Since the beginning of plastic production in the 20th century, until 2015, the world has produced some 6.3 billion tonnes of plastic waste, only 9% of which has been recycled, and only ~1% has been recycled more than once. Additionally, 12% was incinerated and the remaining 79% disposed of to landfill or to the environment including the sea. Recycling is necessary because almost all plastic is non-biodegradable and thus builds-up in the environment, where it can cause harm. For example, approximately 8 million tons of waste plastic enter the Earth's oceans every year, causing damage to the aquatic ecosystem and ...
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Granulation
Granulation is the process of forming grains or granules from a powdery or solid substance, producing a granular material. It is applied in several technological processes in the chemical and pharmaceutical industries. Typically, granulation involves agglomeration of fine particles into larger granules, typically of size range between 0.2 and 4.0 mm depending on their subsequent use. Less commonly, it involves shredding or grinding solid material into finer granules or pellets. From powder The granulation process combines one or more powder particles and forms a granule that will allow tableting to be within required limits. It is the process of collecting particles together by creating bonds between them. Bonds are formed by compression or by using a binding agent. Granulation is extensively used in the pharmaceutical industry, for manufacturing of tablets and pellets. This way predictable and repeatable process is possible and granules of consistent quality can be produced ...
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Screw Conveyor
A screw conveyor or auger conveyor is a mechanism that uses a rotating helical screw blade, called a "''flighting''", usually within a tube, to move liquid or granular materials. They are used in many bulk handling industries. Screw conveyors in modern industry are often used horizontally or at a slight incline as an efficient way to move semi-solid materials, including food waste, wood chips, aggregates, cereal grains, animal feed, boiler ash, meat, and bone meal, municipal solid waste, and many others. The first type of screw conveyor was the Archimedes' screw, used since ancient times to pump irrigation water. They usually consist of a trough or tube containing either a spiral blade coiled around a shaft, driven at one end and held at the other, or a "''shaftless spiral''", driven at one end and free at the other. The rate of volume transfer is proportional to the rotation rate of the shaft. In industrial control applications, the device is often used as a variable rate f ...
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Die (manufacturing)
A die is a specialized machine tool used in manufacturing industries to cut and/or form material to a desired shape or profile. Stamping dies are used with a press, as opposed to drawing dies (used in the manufacture of wire) and casting dies (used in molding) which are not. Like molds, dies are generally customized to the item they are used to create. Products made with dies range from simple paper clips to complex pieces used in advanced technology. Continuous-feed laser cutting may displace the analogous die-based process in the automotive industry, among others. Die stamping Blanking and piercing are two die cutting operations, and bending is an example of a die forming operation. Die forming Forming operations work by deforming materials like sheet metal or plastic using force (compression, tension, or both) and rely on the material's mechanical properties. Forming dies are typically made by tool and die makers and put into production after mounting into a press. ...
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Extrusion
Extrusion is a process used to create objects of a fixed cross-sectional profile by pushing material through a die of the desired cross-section. Its two main advantages over other manufacturing processes are its ability to create very complex cross-sections; and to work materials that are brittle, because the material encounters only compressive and shear stresses. It also creates excellent surface finish and gives considerable freedom of form in the design process. Drawing is a similar process, using the tensile strength of the material to pull it through the die. It limits the amount of change that can be performed in one step, so it is limited to simpler shapes, and multiple stages are usually needed. Drawing is the main way to produce wire. Metal bars and tubes are also often drawn. Extrusion may be continuous (theoretically producing indefinitely long material) or semi-continuous (producing many pieces). It can be done with hot or cold material. Commonly extruded materials ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ...
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Batch Production
Batch production is a method of manufacturing where the products are made as specified groups or amounts, within a time frame. A batch can go through a series of steps in a large manufacturing process to make the final desired product. Batch production is used for many types of manufacturing that may need smaller amounts of production at a time to ensure specific quality standards or changes in the process. This is opposed to large mass production or continuous production methods where the product or process does not need to be checked or changed as frequently or periodically. Characteristics In the manufacturing batch production process, the machines are in chronological order directly related to the manufacturing process. The batch production method is also used so any temporary changes or modifications can be made to the product if necessary during the manufacturing process. For example, if a product needed a sudden change in material or details changed, it can be done in be ...
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Mill (grinding)
A mill is a device, often a structure, machine or kitchen appliance, that breaks solid materials into smaller pieces by grinding, crushing, or cutting. Such comminution is an important unit operation in many processes. There are many different types of mills and many types of materials processed in them. Historically mills were powered by hand or by animals (e.g., via a hand crank), working animal (e.g., horse mill), wind (windmill) or water (watermill). In modern era, they are usually powered by electricity. The grinding of solid materials occurs through mechanical forces that break up the structure by overcoming the interior bonding forces. After the grinding the state of the solid is changed: the grain size, the grain size disposition and the grain shape. Milling also refers to the process of breaking down, separating, sizing, or classifying aggregate material (e.g. mining ore). For instance rock crushing or grinding to produce uniform aggregate size for construction purp ...
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Polyvinyl Pyrrolidone
Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-Vinylpyrrolidone, ''N''-vinylpyrrolidone. PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties. Uses Medical It is used as a excipient#Binders, binder in many pharmaceutical tablets; it simply passes through the body when taken orally. PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessary, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and povidone-iodine, Betadine, among a plethora of others. It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low c ...
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