Emergency Preservation And Resuscitation
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Emergency Preservation And Resuscitation
Emergency Preservation and Resuscitation (EPR) is an experimental medical procedure where an emergency department patient is cooled into suspended animation for an hour to prevent incipient death from ischemia, such as the blood loss following a shooting or stabbing. EPR uses hypothermia, drugs, and fluids to "buy time" for resuscitative surgery. If successful, EPR may someday be deployed in the field so that paramedics can suspend and preserve patients for transport. EPR is similar to deep hypothermic circulatory arrest (DHCA) in that hypothermia is induced. However, the purposes and procedures of EPR differ from DHCA. DHCA induces hypothermia to aid preplanned surgery, whereas EPR is an emergency procedure in cases where an emergency department patient is rapidly dying from blood loss and will not otherwise survive long enough for the patient's wounds to be stitched up. In EPR, blood is replaced by a saline solution, and the patient is cooled into a suspended state where metaboli ...
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Emergency Department
An emergency department (ED), also known as an accident and emergency department (A&E), emergency room (ER), emergency ward (EW) or casualty department, is a medical treatment facility specializing in emergency medicine, the acute care of patients who present without prior appointment; either by their own means or by that of an ambulance. The emergency department is usually found in a hospital or other primary care center. Due to the unplanned nature of patient attendance, the department must provide initial treatment for a broad spectrum of illnesses and injuries, some of which may be life-threatening and require immediate attention. In some countries, emergency departments have become important entry points for those without other means of access to medical care. The emergency departments of most hospitals operate 24 hours a day, although staffing levels may be varied in an attempt to reflect patient volume. History Accident services were provided by workmen's compensation ...
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Suspended Animation
Suspended animation is the temporary (short- or long-term) slowing or stopping of biological function so that physiological capabilities are preserved. It may be either hypometabolic or ametabolic in nature. It may be induced by either endogenous, natural or artificial biological, chemical or physical means. In its natural form it may be spontaneously reversible as in the case of species demonstrating hypometabolic states of hibernation or require technologically mediated revival when applied with therapeutic intent in the medical setting as in the case of deep hypothermic circulatory arrest (DHCA). Basic principles Suspended animation is understood as the pausing of life processes by exogenous or endogenous means without terminating life itself. Breathing, heartbeat and other involuntary functions may still occur, but they can only be detected by artificial means. For this reason, this procedure has been associated with a lethargic state in nature when animals or plants app ...
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Ischemia
Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue i.e. hypoxia and microvascular dysfunction. It also implies local hypoxia in a part of a body resulting from constriction (such as vasoconstriction, thrombosis, or embolism). Ischemia causes not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. Ischemia can be partial (poor perfusion) or total blockage. The inadequate delivery of oxygenated blood to the organs must be resolved either by treating the cause of the inadequate delivery or reducing the oxygen demand of the system that needs it. For example, patients with myocardial ischemia have a decreased blood flow to the heart and are prescribed with medi ...
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Hypothermia
Hypothermia is defined as a body core temperature below in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe hypothermia, there may be hallucinations and paradoxical undressing, in which a person removes their clothing, as well as an increased risk of the heart stopping. Hypothermia has two main types of causes. It classically occurs from exposure to cold weather and cold water immersion. It may also occur from any condition that decreases heat production or increases heat loss. Commonly, this includes alcohol intoxication but may also include low blood sugar, anorexia and advanced age. Body temperature is usually maintained near a constant level of through thermoregulation. Efforts to increase body temperature involve shivering, increased voluntary activity, and putting on warmer clothing. Hypothermia may be diagnosed based on either a person ...
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Deep Hypothermic Circulatory Arrest
Deep hypothermic circulatory arrest (DHCA) is a surgical technique that induces deep medical hypothermia. It involves cooling the body to temperatures between 20 °C (68  °F) to 25 °C (77 °F), and stopping blood circulation and brain function for up to one hour. It is used when blood circulation to the brain must be stopped because of delicate surgery within the brain, or because of surgery on large blood vessels that lead to or from the brain. DHCA is used to provide a better visual field during surgery due to the cessation of blood flow. DHCA is a form of carefully managed clinical death in which heartbeat and all brain activity cease. At normal body temperature of 37 °C only several minutes of stopped blood circulation causes changes within the brain leading to permanent damage after circulation is restored. Reducing body temperature extends the time interval that such stoppage can be survived. At a brain temperature of 14 °C, blood circulation ...
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Cardiac Arrest
Cardiac arrest is when the heart suddenly and unexpectedly stops beating. It is a medical emergency that, without immediate medical intervention, will result in sudden cardiac death within minutes. Cardiopulmonary resuscitation (CPR) and possibly defibrillation are needed until further treatment can be provided. Cardiac arrest results in a rapid loss of consciousness, and breathing may be abnormal or absent. While cardiac arrest may be caused by heart attack or heart failure, these are not the same, and in 15 to 25% of cases, there is a non-cardiac cause. Some individuals may experience chest pain, shortness of breath, nausea, an elevated heart rate, and a light-headed feeling immediately before entering cardiac arrest. The most common cause of cardiac arrest is an underlying heart problem like coronary artery disease that decreases the amount of oxygenated blood supplying the heart muscle. This, in turn, damages the structure of the muscle, which can alter its function. ...
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Peter Safar
Peter Safar (12 April 19242 August 2003) was an Austrian anesthesiologist of Czech descent. He is credited with pioneering cardiopulmonary resuscitation (CPR). Early life Safar was born in Vienna, Austria, in 1924 into a medical family. His father, Karl, was an ophthalmologist and his mother, Vinca (Landauer), who had a Jewish grandmother, was a pediatrician. He graduated from the University of Vienna in 1948. He married Eva Kyzivat and moved from Vienna to Hartford, Connecticut, in 1949 for surgical training at Yale University. He completed training in anesthesiology at the University of Pennsylvania in 1952. That same year he worked in Lima, Peru, and founded that country's first academic anesthesiology department. In 1954, he became chief of the department of anesthesiology at Baltimore City Hospital. Cardiopulmonary resuscitation Together with James Elam, he rediscovered the initial steps in CPR. These included the head tilt and chin lift maneuver to open the airway of an un ...
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New Scientist
''New Scientist'' is a magazine covering all aspects of science and technology. Based in London, it publishes weekly English-language editions in the United Kingdom, the United States and Australia. An editorially separate organisation publishes a monthly Dutch-language edition. First published on 22 November 1956, ''New Scientist'' has been available in online form since 1996. Sold in retail outlets (paper edition) and on subscription (paper and/or online), the magazine covers news, features, reviews and commentary on science, technology and their implications. ''New Scientist'' also publishes speculative articles, ranging from the technical to the philosophical. ''New Scientist'' was acquired by Daily Mail and General Trust (DMGT) in March 2021. History Ownership The magazine was founded in 1956 by Tom Margerison, Max Raison and Nicholas Harrison as ''The New Scientist'', with Issue 1 on 22 November 1956, priced at one shilling (a twentieth of a pound in pre-decimal UK cu ...
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Peter Rhee
Peter Meong Rhee (born September 18, 1961) is an American surgeon, medical professor, and military veteran. During his 24 years in the United States Navy, Rhee served as a battlefield casualty physician in Afghanistan and Iraq. Formerly a Professor of Surgery and the Chief of Trauma, Critical Care, and Burn and Emergency Surgery at the University of Arizona College of Medicine until 2016, he then served as the Chief of Surgery at the Marcus Trauma Center at Grady Memorial Hospital in Atlanta, Georgia. Currently he is the Director of the surgical ICU at St. Barnabas Hospital in the Bronx, New York. He was a tenured Professor of Surgery at the University of Arizona until 2016. Now he is Professor of Surgery at the Uniformed Services University of the Health Sciences in Bethesda Maryland, Morehouse School of Medicine and is a tenured Professor of Surgery at the New York Medical College in Valhalla, New York. He rose to national prominence when he served as the attending physician t ...
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University Of Arizona
The University of Arizona (Arizona, U of A, UArizona, or UA) is a public land-grant research university in Tucson, Arizona. Founded in 1885 by the 13th Arizona Territorial Legislature, it was the first university in the Arizona Territory. The university is part of the Association of American Universities and the Universities Research Association. In the former, it is the only member from the state of Arizona. The university is classified among "R1: Doctoral Universities – Very High Research Activity". The University of Arizona is one of three universities governed by the Arizona Board of Regents. , the university enrolled 49,471 students in 19 separate colleges/schools, including the University of Arizona College of Medicine in Tucson and Phoenix and the James E. Rogers College of Law, and is affiliated with two academic medical centers ( Banner – University Medical Center Tucson and Banner – University Medical Center Phoenix). In 2021, University of Arizona acquired ...
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United States Department Of Defense
The United States Department of Defense (DoD, USDOD or DOD) is an executive branch department of the federal government charged with coordinating and supervising all agencies and functions of the government directly related to national security and the United States Armed Forces. The DoD is the largest employer in the world, with over 1.34 million active-duty service members (soldiers, marines, sailors, airmen, and guardians) as of June 2022. The DoD also maintains over 778,000 National Guard and reservists, and over 747,000 civilians bringing the total to over 2.87 million employees. Headquartered at the Pentagon in Arlington, Virginia, just outside Washington, D.C., the DoD's stated mission is to provide "the military forces needed to deter war and ensure our nation's security". The Department of Defense is headed by the secretary of defense, a cabinet-level head who reports directly to the president of the United States. Beneath the Department of Defense are th ...
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