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Esoderm
Lindane, also known as ''gamma''-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC), is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies. Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. In humans, lindane affects the nervous system, liver, and kidneys, and may well be a carcinogen. Whether lindane is an endocrine disruptor is unclear. The World Health Organization classifies lindane as "moderately hazardous", and its international trade is restricted and regulated under the Rotterdam Convention on Prior Informed Consent.World Health Organization''The WHO Recommended Classification of Pesticides by Hazard'' 2005. In 2009, the production and agricultural use of lindane was banned under the Stockholm Co ...
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Nervous System
In biology, the nervous system is the complex system, highly complex part of an animal that coordinates its behavior, actions and sense, sensory information by transmitting action potential, signals to and from different parts of its body. The nervous system detects environmental changes that impact the body, then works in tandem with the endocrine system to respond to such events. Nervous tissue first arose in Ediacara biota, wormlike organisms about 550 to 600 million years ago. In Vertebrate, vertebrates, it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed bundles of the long fibers, or axons, that connect the CNS to every other part of the body. Nerves that transmit signals from the brain are called motor nerves (efferent), while those nerves that transmit information from the body to the CNS are called sensory nerves (aff ...
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Kidneys
In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood exits into the paired renal veins. Each kidney is attached to a ureter, a tube that carries excreted urine to the bladder. The kidney participates in the control of the volume of various body fluids, fluid osmolality, acid-base balance, various electrolyte concentrations, and removal of toxins. Filtration occurs in the glomerulus: one-fifth of the blood volume that enters the kidneys is filtered. Examples of substances reabsorbed are solute-free water, sodium, bicarbonate, glucose, and amino acids. Examples of substances secreted are hydrogen, ammonium, potassium and uric acid. The nephron is the structural and functi ...
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Liver
The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of various proteins and various other Biochemistry, biochemicals necessary for digestion and growth. In humans, it is located in the quadrants and regions of abdomen, right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm and mostly shielded by the lower right rib cage. Its other metabolic roles include carbohydrate metabolism, the production of a number of hormones, conversion and storage of nutrients such as glucose and glycogen, and the decomposition of red blood cells. Anatomical and medical terminology often use the prefix List of medical roots, suffixes and prefixes#H, ''hepat-'' from ἡπατο-, from the Greek language, Greek word for liver, such as hepatology, and hepatitis The liver is also an accessory digestive ...
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Stockholm Convention
Stockholm Convention on Persistent Organic Pollutants is an international environmental treaty, signed on 22 May 2001 in Stockholm and effective from 17 May 2004, that aims to eliminate or restrict the production and use of persistent organic pollutants (POPs). History In 1995, the Governing Council of the United Nations Environment Programme (UNEP) called for global action to be taken on POPs, which it defined as "chemical substances that persist in the environment, bio-accumulate through the food web, and pose a risk of causing adverse effects to human health and the environment". Following this, the Intergovernmental Forum on Chemical Safety (IFCS) and the International Programme on Chemical Safety (IPCS) prepared an assessment of the 12 worst offenders, known as the ''dirty dozen''. The INC met five times between June 1998 and December 2000 to elaborate the convention, and delegates adopted the Stockholm Convention on POPs at the Conference of the Plenipotentiaries c ...
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Imperial Chemical Industries
Imperial Chemical Industries (ICI) was a British Chemical industry, chemical company. It was, for much of its history, the largest manufacturer in Britain. Its headquarters were at Millbank in London. ICI was listed on the London Stock Exchange and was a constituent of the FT 30 and later the FTSE 100 Index, FTSE 100 indices. ICI was formed in 1926 as a result of the merger of four of Britain's leading chemical companies. From the onset, it was involved in the production of various chemicals, explosives, fertilisers, insecticides, dyestuffs, non-ferrous metals, and paints; the firm soon become involved in plastics and a variety of speciality products, including food ingredients, polymers, electronic materials, fragrances and flavourings. During the Second World War, ICI's subsidiary Nobel Enterprises, ICI Nobel produced munitions for Britain's war effort; the wider company was also involved with Britain's nuclear weapons programme codenamed Tube Alloys. Throughout the 1940s and ...
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Michael Faraday
Michael Faraday (; 22 September 1791 – 25 August 1867) was an English chemist and physicist who contributed to the study of electrochemistry and electromagnetism. His main discoveries include the principles underlying electromagnetic induction, diamagnetism, and electrolysis. Although Faraday received little formal education, as a self-made man, he was one of the most influential scientists in history. It was by his research on the magnetic field around a Electrical conductor, conductor carrying a direct current that Faraday established the concept of the electromagnetic field in physics. Faraday also established that magnetism could Faraday effect, affect rays of light and that there was an underlying relationship between the two phenomena. the 1911 ''Encyclopædia Britannica''. He similarly discovered the principles of electromagnetic induction, diamagnetism, and the Faraday's laws of electrolysis, laws of electrolysis. His inventions of electric motor, electromagnetic rotar ...
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Multiple Discovery
The concept of multiple discovery (also known as simultaneous invention) is the hypothesis that most scientific discoveries and inventions are made independently and more or less simultaneously by multiple scientists and inventors. The concept of multiple discovery opposes a traditional view—the "heroic theory" of invention and discovery. Multiple discovery is analogous to convergent evolution in biological evolution. Multiples When Nobel laureates are announced annually—especially in physics, chemistry, physiology, medicine, and economics—increasingly, in the given field, rather than just a single laureate, there are two, or the maximally permissible three, who often have independently made the same discovery. Historians and sociologists have remarked the occurrence, in science, of "multiple independent discovery". Robert K. Merton defined such "multiples" as instances in which similar discoveries are made by scientists working independently of each other. Merton con ...
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Jealott's Hill
Jealott's Hill is a village in the county of Berkshire, England, within the civil parish of Warfield. The settlement is on the A3095 road approximately north of Bracknell. The nearest railway station is in . History The name of the hill is reported to have derived from the surname of a 14th-century landowner, Roger Jolyl. This name evolved into "Joyliff's Hill" and then, on Henry Walter's ''Map of Windsor Forest, 1823'', became "Jealous Hill". This changed again to "Jealot's Hill" on John Snare's 1846 map and by the 1920s the modern spelling was established. Syngenta research site Jealott's Hill is home to Syngenta's largest research and development site which includes a large agricultural research greenhouse at and a farm. , Syngenta employed around 800 people there. The site was formed in 1927 by the amalgamation of three farms, Hawthorndale, Nuptown and Jealott's Hill itself. Jealott's Hill House was built in 1928 and officially opened on 28 June 1929 as the offices, lab ...
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World War II
World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the world's countries participated, with many nations mobilising all resources in pursuit of total war. Tanks in World War II, Tanks and Air warfare of World War II, aircraft played major roles, enabling the strategic bombing of cities and delivery of the Atomic bombings of Hiroshima and Nagasaki, first and only nuclear weapons ever used in war. World War II is the List of wars by death toll, deadliest conflict in history, causing World War II casualties, the death of 70 to 85 million people, more than half of whom were civilians. Millions died in genocides, including the Holocaust, and by massacres, starvation, and disease. After the Allied victory, Allied-occupied Germany, Germany, Allied-occupied Austria, Austria, Occupation of Japan, Japan, a ...
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Rotterdam Convention
The Rotterdam Convention (formally, the Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade) is a multilateral treaty to promote shared responsibilities in relation to importation of hazardous chemicals. The convention promotes open exchange of information and calls on exporters of hazardous chemicals to use proper labeling, include directions on safe handling, and inform purchasers of any known restrictions or bans. Signatory nations can decide whether to allow or ban the importation of chemicals listed in the treaty, and exporting countries are obliged to make sure that producers within their jurisdiction comply. In 2012, the Secretariats of the Basel Convention, Basel and Stockholm Convention on Persistent Organic Pollutants, Stockholm conventions, as well as the United Nations Environment Programme, UNEP-part of the Rotterdam Convention Secretariat, merged to a single Secretariat with a matrix s ...
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Derris Elliptica
''Derris eliptica'' is a species of leguminous plant from Southeast Asia and the southwest Pacific islands, including New Guinea. The roots of ''D. elliptica'' contain rotenone, a strong insecticide and fish poison. Also known as ''derris powder'' and ''tuba root'' (in Indonesia), it was formerly used as an organic insecticide used to control pests on crops such as peas. However, due to studies revealing the extreme toxicity of rotenone to which the powder is often refined, it is unsafe: in spite of its popularity with organic growers. Derris root, when crushed, releases rotenone. Some native residents of Fiji and New Guinea practice a form of fishing in which they crush the roots and throw them into the water. The stunned or killed fish float to the surface where they can be easily reached. Despite its toxicity, ''Derris'' is used as a food plant by Lepidopteran larvae including '' Batrachedra amydraula''. Subspecies The following subspecies are listed:Roskov Y., Kunze T., O ...
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Rotenone
Rotenone is an odorless, colorless, crystalline isoflavone. It occurs naturally in the seeds and stems of several plants, such as the jicama vine, and in the roots of several other members of the Fabaceae. It was the first-described member of the family of chemical compounds known as rotenoids. Rotenone is approved for use as a piscicide to remove alien fish species, see ''Uses.'' It has also been used as a broad-spectrum insecticide, but its use as an insecticide has been banned in many countries. Discovery The earliest written record of the now-known rotenone-containing plants used for killing leaf-eating caterpillars was in 1848; for centuries, these same plants had been used to poison fish. The active chemical component was first isolated in 1895 by a French botanist, Emmanuel Geoffroy, who called it ''nicouline'', from a specimen of ''Robinia nicou'', now called '' Deguelia utilis'', while traveling in French Guiana. He wrote about this research in his thesis, publishe ...
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