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Déborah Bourc'his
Déborah Bourc'his is a French researcher in Epigenetics. She is currently a team leader at the Curie Institute (Paris). Her research has been awarded the prize Liliane-Bettencourt for life sciences. Education and academic appointments In 1996., she joins the laboratory of Evani Viegas-Pequignot to do a PhD in Genetics in at the Necker–Enfants Malades Hospital. There, she identifies methylation mutations on DNMT3B. In 2000, she moves to the laboratory of Timothy Bestor at the Columbia University to start her postdoctoral studies. In 2009, after being recruited at the French biomedical research institute Inserm, she is invited by Edith Heard to start her own research team at the Curie Institute (Paris). Research During her postdoctoral studies, she shows that germline cells require a specific stimulation to acquire DNA methylation, via the cofactor 3 DNMT3L. Déborah Bourc'his runs a research team studying epigenetic decisions and reproduction in the department 'Genetics an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetics
In biology, epigenetics is the study of changes in gene expression that happen without changes to the DNA sequence. The Greek prefix ''epi-'' (ἐπι- "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional (DNA sequence based) genetic mechanism of inheritance. Epigenetics usually involves a change that is not erased by cell division, and affects the regulation of gene expression. Such effects on cellular and physiological traits may result from environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Further, non-coding RNA sequences have been shown to play a key role in the r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Curie Institute (Paris)
Centre of protontherapy Institut Curie is a medical, biological and biophysical research centre in France. It is a private non-profit foundation operating a research center on biophysics, cell biology and oncology and a hospital specialized in treatment of cancer. It is located in Paris, France. Institut Curie is member of EU-LIFE, an alliance of leading life sciences research centres in Europe. Research The institute now operates several research units in cooperation with national research institutions CNRS and INSERM. There are several hundred research staff at the institute. ''Institut Curie'' does not offer undergraduate degrees, but awards PhDs and employs many postdoctoral students alongside its permanent staff. Institut Curie is a constituent college (associate member) of University PSL. Hospital ''Institut Curie'' runs the ''Hôpital Claudius Régaud'', a hospital specializing in cancer. The institute also operates the proton therapy center at Orsay, one of the few ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Phenotypic trait, Trait inheritance and Molecular genetics, molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the Cell (bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Necker–Enfants Malades Hospital
The Necker–Enfants Malades Hospital ( ) is a French teaching hospital in the 15th arrondissement of Paris. It is a hospital of the Assistance Publique – Hôpitaux de Paris group and is affiliated to the Université Paris Cité. Necker–Enfants Malades Hospital was created in 1920 by the merger of Necker Hospital (), which was founded in 1778 by Suzanne Necker, with the physically contiguous Sick Children's Hospital (), the oldest children's hospital in the Western world, founded in 1801. History The ''Hôpital Necker'' was founded in 1778 by Madame Necker, born Suzanne Curchod, mother of Madame de Staël and wife of Jacques Necker, Louis XVI's finance minister. Jacques Necker was a leader in the movement to reform crowded hospitals by building smaller treatment centers closer to the patients' neighborhoods. Madame Necker subsequently remodeled an old monastery into the hospital, which prior to the French Revolution was known as the Hospice de Charité. It was a Catholic in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNMT3B
DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome. Function CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in ''de novo'' methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. Clinical significance Immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome is a result of defects in lymphocyte maturation resulting from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia University
Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church (Manhattan), Trinity Church in Manhattan, it is the oldest institution of higher education in New York (state), New York and the fifth-First university in the United States, oldest in the United States. Columbia was established as a Colonial colleges, colonial college by royal charter under George II of Great Britain. It was renamed Columbia College (New York), Columbia College in 1784 following the American Revolution, and in 1787 was placed under Trustees of Columbia University in the City of New York, a private board of trustees headed by former students Alexander Hamilton and John Jay. In 1896, the campus was moved to its current location in Morningside Heights and renamed Columbia University. Columbia is organized into twenty schoo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inserm
The (Inserm, ) is the French National Institute of Health and Medical Research. History and organisation Inserm was created in 1964 as a successor to the French National Institute of Health. Inserm is the only public research institution solely focused on human health and medical research in France. It is a public institution with a scientific and technical vocation under the dual auspices of the Ministry of Health and the Ministry of Research. Similarly to the US National Institutes of Health, Inserm conducts fundamental and translational research projects through 339 research units, run by around 13,000 scientists, including 5,100 permanent research staff members and 5,100 staff members co-affiliated with university hospitals and medicine faculties. Inserm's laboratories and research units are located all over France, mainly in the largest cities. Eighty percent of Inserm research units are embedded in research hospitals of French universities. In 1997, Inserm founded ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edith Heard
Edith Heard (born 1965) is a British-French researcher in epigenetics who has been serving as the Director General of the European Molecular Biology Laboratory (EMBL) since January 2019. She is also Professor at the Collège de France, holding the Chair of Epigenetics and Cellular Memory. In 2025 she will become CEO of the Francis Crick Institute in London, U.K. From 2010 to 2018, Heard was the Director of the Genetics and Developmental Biology department at the Curie Institute (Paris), France. Heard is noted for her studies of X-chromosome- inactivation. Education Heard graduated with a Bachelor of Arts degree in Natural Sciences (Genetics) from the University of Cambridge as a student of Emmanuel College, Cambridge, graduating in 1986. She was awarded a PhD from Imperial College London for research investigating gene amplification in rat cells in 1990 while working at the Imperial Cancer Research Fund Laboratory in London, UK. Career and research Heard's main areas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNMT3L
DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the ''DNMT3L'' gene. Function CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gametogenesis
Gametogenesis is a biological process by which diploid or haploid precursor cells undergo cell division and differentiation to form mature haploid gametes. Depending on the biological life cycle of the organism, gametogenesis occurs by meiotic division of diploid gametocytes into various gametes, or by mitosis. For example, plants produce gametes through mitosis in gametophytes. The gametophytes grow from haploid spores after sporic meiosis. The existence of a multicellular, haploid phase in the life cycle between meiosis and gametogenesis is also referred to as alternation of generations. It is the biological process of gametogenesis during which cells that are haploid or diploid divide to create other cells. It can take place either through mitotic or meiotic division of diploid gametocytes into different cells depending on an organism's biological life cycle. For instance, gametophytes in plants undergo mitosis to produce gametes. Both male and female have different forms. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Geneticists
French may refer to: * Something of, from, or related to France ** French language, which originated in France ** French people, a nation and ethnic group ** French cuisine, cooking traditions and practices Arts and media * The French (band), a British rock band * "French" (episode), a live-action episode of ''The Super Mario Bros. Super Show!'' * ''Française'' (film), a 2008 film * French Stewart (born 1964), American actor Other uses * French (surname), a surname (including a list of people with the name) * French (tunic), a type of military jacket or tunic * French's, an American brand of mustard condiment * French (catheter scale), a unit of measurement * French Defence, a chess opening * French kiss, a type of kiss See also * France (other) * Franch, a surname * French Revolution (other) * French River (other), several rivers and other places * Frenching (other) * Justice French (other) Justice French may refer to: * C. G. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Women Geneticists
A woman is an adult female human. Before adulthood, a female child or adolescent is referred to as a girl. Typically, women are of the female sex and inherit a pair of X chromosomes, one from each parent, and women with functional uteruses are capable of pregnancy and giving birth from puberty until menopause. More generally, sex differentiation of the female fetus is governed by the lack of a present, or functioning, ''SRY'' gene on either one of the respective sex chromosomes. Female anatomy is distinguished from male anatomy by the female reproductive system, which includes the ovaries, fallopian tubes, uterus, vagina, and vulva. An adult woman generally has a wider pelvis, broader hips, and larger breasts than an adult man. These characteristics facilitate childbirth and breastfeeding. Women typically have less facial and other body hair, have a higher body fat composition, and are on average shorter and less muscular than men. Throughout human history, traditional ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
