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DCL2
DCL2 (an abbreviation of Dicer-like 2) is a gene in plants that codes for the DCL2 protein, a ribonuclease III enzyme involved in processing exogenous Double-stranded RNA, double-stranded RNA (dsRNA) into 22 nucleotide Small interfering RNA, small interference RNAs (siRNAs). Diverse sources of dsRNAs have been characterized, broadly classified as exogenous or endogenous. A classical example of exogenous derived dsRNAs are the viral genomes release during infection, specially from those double-stranded RNA viruses, where the cleavage of dsRNA produce small RNA products called viral siRNAs or vsi-RNAs. Other examples of exogenous source of dsRNAs are Transgene, transgenic with several insertion loci along the plant hos genome. DCL2 also process endogenous sources as double-stranded RNAs derived of ''cis-''natural antisense transcripts, generating 22nt short interfering RNA (natsi-RNAs); however, the biological relevance, evolutionary conservation, and experimental validation of natsi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DCL1
DCL1 (an abbreviation of Dicer-like 1) is a gene in plants that codes for the DCL1 protein, a ribonuclease III enzyme involved in processing double-stranded RNA (dsRNA) and microRNA (miRNA). Although DCL1, also called Endoribonuclease Dicer homolog 1, is named for its homology with the metazoan protein Dicer, its role in miRNA biogenesis is somewhat different, due to substantial differences in miRNA maturation processes between plants and animals, as well due to additional downstream plant-specific pathways, where DCL1 paralogs like DCL4 participate, such Trans-acting siRNA biogenesis. Function DCL1 is localized exclusively in the plant cell nucleus, together with the double-stranded RNA binding protein Hyponastic Leaves1 ( HYL1), CTD-Phosphatase-Like1 (CPL1) and the zinc finger protein SERRATE (SE), form nuclear dicing bodies or D-bodies. In these membraneless organelles, pri-miRNAs are recognized and processes into pre-miRNAs and subsequently into mature miRNA duplexes, by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
