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Cardiac Neural Crest Cells
Neural crest cells are multipotent cells required for the development of cells, tissues and organ systems. A subpopulation of neural crest cells are the cardiac neural crest complex. This complex refers to the cells found amongst the midotic placode and somite 3 destined to undergo epithelial-mesenchymal transformation and migration to the heart via pharyngeal arches 3, 4 and 6. The cardiac neural crest complex plays a vital role in forming connective tissues that aid in outflow septation and modelling of the aortic arch arteries during early development. Ablation of the complex often leads to impaired myocardial functioning similar to symptoms present in DiGeorge syndrome. Consequently, the removal of cardiac crest cells that populate in pharyngeal arches has flow on effects on the thymus, parathyroid and thyroid gland. Neural crest cells are a group of temporary, Cell potency#Multipotency, multipotent (can give rise to some other types of cells but not all) cells that are pinche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Crest Cells
Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, Peripheral nervous system, peripheral and enteric neurons and glia. After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm. During neurulation, the borders of the neural plate, also known as the neural folds, converge at the dorsal midline to form the neural tube. Subsequently, neural crest cells from the roof plate of the neural tube undergo an Epithelial-mesenchymal transition, epithelial to mesenchymal transition, delaminating from the neuroepithelial cell, neuroepithelium and migrating through the periphery where they differentiate into varied cell types. The emergence of neural crest was important in vertebrate evolution because many of its structural derivatives are defining f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Septum
In biology, a septum (Latin for ''something that encloses''; plural septa) is a wall, dividing a cavity or structure into smaller ones. A cavity or structure divided in this way may be referred to as septate. Examples Human anatomy * Interatrial septum, the wall of tissue that is a sectional part of the left and right atria of the heart * Interventricular septum, the wall separating the left and right ventricles of the heart * Lingual septum, a vertical layer of fibrous tissue that separates the halves of the tongue. *Nasal septum: the cartilage wall separating the nostrils of the nose * Alveolar septum: the thin wall which separates the alveoli from each other in the lungs * Orbital septum, a palpebral ligament in the upper and lower eyelids * Septum pellucidum or septum lucidum, a thin structure separating two fluid pockets in the brain * Uterine septum, a malformation of the uterus * Vaginal septum, a lateral or transverse partition inside the vagina * Intermuscular sep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recognition Signal
A recognition signal is a signal whereby a person, a ship, an airplane or something else is recognized. They can be used during war or can be used to help the police recognize each other during undercover operations. It can also be used in biology to signal that a molecule or chemical is to be bound to another molecule. War These signals are often used to recognize friends and enemies in a war. For military use these signals often use colored lights or the International marine signal flags Police Other uses of the signal include the police who sometimes use a recognition signal so that officers in uniform can recognize officers in normal clothing (undercover). The NYPD often use headbands, wristbands or colored clothing as recognition signals which are known as the "color of the day". Biology A recognition signal is also a chemical signal used in biology to signal the end of a section of DNA or RNA during gene duplication in cells. See also *Communication *International Code ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bone Morphogenetic Protein
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signalling in pathological processes. Cancerous disease often involves misregulation of the BMP signalling system. Absence of BMP signalling is, for instance, an important factor in the progression of colon cancer, and conversely, overactivation of BMP signalling following reflux-induced esophagitis provokes Barrett's esophagus and is thus instrumental in the development of esophageal adenocarcinoma. Recombinant human BMPs (rhBMPs) are used in orthopedic applications such as spinal fusions, nonunions, and oral surgery. rhBMP-2 and rhBMP-7 are F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroblast Growth Factor
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function lead to a range of developmental defects. These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. A defining property of FGFs is that they bind to heparin and to heparan sulfate. Thus, some are sequestered in the extracellular matrix of tissues that contains heparan sulfate proteoglycans and are released locally upon injury or tissue remodeling. Families In humans, 23 members of the FGF family have been identified, all of which are ''structurally'' related signaling molecules: * Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as ''acidic fibroblast growth factor'', and FGF2 is also known a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wnt Signaling Pathway
The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part by the SPATS1 gene. The noncanonical plana ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Fold
The neural fold is a structure that arises during neurulation in the embryonic development of both birds and mammals among other organisms. This structure is associated with primary neurulation, meaning that it forms by the coming together of tissue layers, rather than a clustering, and subsequent hollowing out, of individual cells (known as secondary neurulation). In humans, the neural folds are responsible for the formation of the anterior end of the neural tube. The neural folds are derived from the neural plate, a preliminary structure consisting of elongated ectoderm cells. The folds give rise to neural crest cells, as well as bringing about the formation of the neural tube. Development In the embryo, the formation of the neural folds originates from the area where the neural plate and the surrounding ectoderm converge. This region of the embryo is formed after gastrulation, and consists of epithelial tissue. Here, the epithelial cells elongate by means of microtubule p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primitive Knot
The primitive node (or primitive knot) is the organizer for gastrulation in most amniote embryos. In birds it is known as Hensen's node, and in amphibians it is known as the Spemann-Mangold organizer. It is induced by the Nieuwkoop center in amphibians, or by the posterior marginal zone in amniotes including birds. Diversity * In birds the organizer is known as Hensen's node, named after its discoverer Victor Hensen. * In other amniotes it is known as the primitive node. * In amphibians, it is known as the Spemann-Mangold organizer, named after Hans Spemann and Hilde Mangold, who first identified the organizer in 1924.) * In fish it is known as the embryonic shield. All structures are as yet considered as homologous. This view is substantiated by the common expression of several genes, including goosecoid, Cnot, noggin, nodal, and the sharing of strong axis-inducing properties upon transplantation. Cell fate studies have revealed that also the overall temporal sequence i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epiblast
In amniote embryonic development, the epiblast (also known as the primitive ectoderm) is one of two distinct cell layers arising from the inner cell mass in the mammalian blastocyst, or from the blastula in reptiles and birds, the other layer is the hypoblast. It derives the embryo proper through its differentiation into the three primary germ layers, ectoderm, mesoderm and endoderm, during gastrulation. The amnionic ectoderm and extraembryonic mesoderm also originate from the epiblast. The other layer of the inner cell mass, the hypoblast, gives rise to the yolk sac, which in turn gives rise to the chorion. Discovery of the epiblast The epiblast was first discovered by Christian Heinrich Pander (1794-1865), a Baltic German biologist and embryologist. With the help of anatomist Ignaz Döllinger (1770–1841) and draftsman Eduard Joseph d'Alton (1772-1840), Pander observed thousands of chicken eggs under a microscope, and ultimately discovered and described the chicken blastoderm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Induction
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology to describe and provide insight into the cellular and molecular mechanisms by which complex nervous systems develop, from nematodes and fruit flies to mammals. Defects in neural development can lead to malformations such as holoprosencephaly, and a wide variety of neurological disorders including limb paresis and paralysis, balance and vision disorders, and seizures, and in humans other disorders such as Rett syndrome, Down syndrome and intellectual disability. Overview of vertebrate brain development The vertebrate central nervous system (CNS) is derived from the ectoderm—the outermost germ layer of the embryo. A part of the dorsal ectoderm becomes specifie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNCC Migration
The China National Convention Center, previously known as the Olympic Green Convention Center () is a convention center located in the Olympic Green in Beijing. History It was designed by RMJM and was originally used for the 2008 Summer Olympics and Paralympics. It covers an area of 270,000 square metres. It was one of the four principal buildings of the Olympic Green. The convention center served as the competition spot for the fencing, and the shooting and fencing parts of the modern pentathlon events in the 2008 Summer Olympics and the boccia and wheelchair fencing events at the 2008 Summer Paralympics. The International Broadcast Centre was located in this venue. and will be used again for the 2022 Winter Olympics. Transportation The nearest subway station is Aolinpike Gongyuan (Olympic Park) station Aolinpike Gongyuan (Olympic Park) station () is an interchange station on Line 8 and Line 15 of the Beijing Subway. The station was named Olympic Green. It was rena ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cartilage
Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck and the bronchial tubes, and the intervertebral discs. In other taxa, such as chondrichthyans, but also in cyclostomes, it may constitute a much greater proportion of the skeleton. It is not as hard and rigid as bone, but it is much stiffer and much less flexible than muscle. The matrix of cartilage is made up of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. Because of its rigidity, cartilage often serves the purpose of holding tubes open in the body. Examples include the rings of the trachea, such as the cricoid cartilage and carina. Cartilage is composed of specialized cells called chondrocytes that produce a large amount of collagenous extracellular matrix, abundant ground substance that is rich in pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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