Triazolobenzodiazepines
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Triazolobenzodiazepines
upChemical structure of alprazolam, a common triazolobenzodiazepine Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional triazole ring fused to the diazepine ring. The triazole and diazepine rings share a nitrogen atom. Examples include: * Adinazolam * Alprazolam * Bromazolam * Clonazolam * Estazolam * Flualprazolam * Flubromazolam * Flunitrazolam * Nitrazolam * Pyrazolam * Triazolam Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepine (BZD) derivatives. It possesses pharmacological properti ... * Zapizolam Synthesis Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2- thiones with hydrazine and acetic acid in ''n''-butanol under reflux.Hester JB, Duchamp DJ ...
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Alprazolam Structure
Alprazolam, sold under the brand name Xanax among others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. Alprazolam is most commonly prescribed in the management of anxiety disorders, especially panic disorder and generalized anxiety disorder (GAD). Other uses include the treatment of Chemotherapy-induced nausea and vomiting, chemotherapy-induced nausea, together with other treatments. GAD improvement occurs generally within a week. Alprazolam is generally taken oral administration, orally. Common side effects include sleepiness, Depression (mood), depression, Reduced affect display, suppressed emotions, mild to severe Ataxia, decreases in motor skills, Hiccup, hiccups, dulling or declining of cognition, decreased alertness, xerostomia, dry mouth (mildly), Bradycardia, decreased heart rate, CNS depression, suppression of central nervous system activity, impairment of judgment (usually in ...
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