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Transferases
In biochemistry, a transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl group, methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds of different Molecular pathway, biochemical pathways throughout biology, and are integral to some of life's most important processes. Transferases are involved in myriad reactions in the cell. Three examples of these reactions are the activity of coenzyme A (CoA) Coenzyme A transferases, transferase, which transfers Thioester, thiol esters, the action of N-acetyltransferase, which is part of the pathway that metabolizes tryptophan, and the regulation of pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl CoA. Transferases are also utilized during translation. In this case, an amino acid chain is the functional group transferred by a peptidyl transferase. The transfer involves the removal of the growing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptidyl Transferase
The peptidyl transferase center (, PTC) is an Aminoacyltransferases, aminoacyltransferase ribozyme (RNA enzyme) located in the large subunit of the ribosome. It forms peptide bonds between adjacent amino acids during the Translation (genetics), translation process of protein biosynthesis. It is also responsible for peptidyl-tRNA hydrolysis, allowing the release of the synthesized peptide chain at the end of translation. Peptidyl transferase activity is not mediated by any ribosomal proteins, but entirely by ribosomal RNA (rRNA). The catalytic activity of the PTC is a significant piece of evidence supporting the RNA World hypothesis. The PTC is a highly conserved region with a very slow rate of mutation. It is considered to be among the most ancient elements of the ribosome, probably predating the last universal common ancestor. The position of the PTC is analogous in all ribosomes (domain V in 23S numbering), being a part of the large subunit ribosomal RNA with the name only va ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
