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Thiazepines
Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine. Benzothiazepines have a single benzene attached to the ring, while dibenzothiazepines have two. Diltiazem, a benzothiazepine, is a calcium channel blocker intermediate in properties between verapamil and the dihydropyridines. It is used to treat variant angina (Prinzmetal's angina), either naturally occurring or drug-induced and stable angina. References External links * {{heterocyclic-stub Thiazepines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiepins
In organic chemistry, thiepine (or thiepin) is an Saturated and unsaturated compounds, unsaturated seven-membered heterocyclic compound, with six carbon atoms and one sulfur atom. The parent compound, C6H6S is unstable and is predicted to be antiaromatic. Bulky derivatives have been isolated and shown by X-ray crystallography to have nonplanar C6S ring. Computational studies suggest that thiepine would eliminate a sulfur atom to form benzene. The intermediate is this process is the bicycle thianorcaradiene. In the complex with (η4-C6H6S)Fe(CO)3, the ring is stable. Benzothiepines have one fused benzene group and ''dibenzothiepines'' such as dosulepin and zotepine have two fused benzene groups. Damotepine is another thiepin derivative. See also * Thiazepines * 2,3-Dihydrothiepine * 2,7-Dihydrothiepine References External links * * {{MeshName, Benzothiepins Thiepines Antiaromatic compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |