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Netrins
Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word "netr", which means "one who guides". Netrins are genetically conserved across nematode worms, fruit flies, frogs, mice, and humans. Structurally, netrin resembles the extracellular matrix protein laminin. Netrins are chemotropic; a growing axon will either move towards or away from a higher concentration of netrin. Though the detailed mechanism of axon guidance is not fully understood, it is known that netrin attraction is mediated through UNC-40/DCC cell surface receptors and repulsion is mediated through UNC-5 receptors. Netrins also act as growth factors, encouraging cell growth activities in target cells. Mice deficient in netrin fail to form the hippocampal comissure or the corpus callosum. A proposed model for netrin activity in the spinal column of developing human embryos is that netrins are released by the floor plate and then are picked up by receptor proteins embe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netrin 1 Knockout Model Cropped
Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word "netr", which means "one who guides". Netrins are Conserved sequence, genetically conserved across Caenorhabditis elegans, nematode worms, Drosophila, fruit flies, Xenopus laevis, frogs, Mus musculus, mice, and Human, humans. Structurally, netrin resembles the extracellular matrix protein laminin. Netrins are chemotropism, chemotropic; a growing axon will either move towards or away from a higher concentration of netrin. Though the detailed mechanism of axon guidance is not fully understood, it is known that netrin attraction is mediated through UNC-40/DCC cell surface receptors and repulsion is mediated through UNC-5 receptors. Netrins also act as growth factors, encouraging cell growth activities in target cells. Mice deficient in netrin fail to form the hippocampal comissure or the corpus callosum. A proposed Scientific modelling, model for netrin activity in the spinal column of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
