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Moderna
Moderna, Inc. ( ) is an American pharmaceutical and biotechnology company based in Cambridge, Massachusetts, that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to carry instructions for proteins to produce an immune response. The company's name is derived from the terms "modified", "RNA", and "modern". The company's commercial products are the Moderna COVID-19 vaccine, marketed as Spikevax and a RSV vaccine, marketed as Mresvia. The company has 44 treatment and vaccine candidates, of which 37 have entered clinical trials. Candidates include possible vaccines for influenza, HIV, Epstein–Barr virus, the Nipah virus, chikungunya, human metapneumovirus, varicella zoster virus, as well as a cytomegalovirus vaccine, a Zika virus vaccine funded by the Biomedical Advanced Research and Development Authority, and three cancer vaccines. History Moderna was founded in 2010 by Derrick Rossi, Timothy A. Springer, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moderna COVID-19 Vaccine
The Moderna COVID19 vaccine, sold under the brand name Spikevax, is a COVID-19 vaccine developed by the American company Moderna, the United States National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA). Depending on the jurisdiction, it is authorized for use in humans aged six months, twelve years, or eighteen years and older. It provides protection against COVID-19, which is caused by infection by the Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 virus. It is designed to be administered in two or three 0.5-Litre#SI prefixes applied to the litre, mL doses given by intramuscular injection, primarily into the deltoid muscle, at an interval of at least 28 days apart. The World Health Organization advises an eight-week interval between doses to optimize efficacy. Additional booster doses are approved in some regions to maintain immunity. Clinical trials and real-world data have demonst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Noubar Afeyan
Noubar Afeyan (Western ; born in 1962) is an American-Canadian entrepreneur, inventor, and philanthropist. He is best known for co-founding the biotechnology company Moderna, through his venture capital firm, Flagship Pioneering, and for co-founding humanitarian projects such as Aurora Prize and ''The Future Armenian''. As of November 2021, his net worth is estimated at $3.3 billion. He was awarded the National Medal of Technology and Innovation in 2025. Personal life Afeyan was born to Armenian parents in Beirut, Lebanon in 1962. His grandfather survived the Armenian genocide. Talking about his background, Afeyan said: "One of the only unfortunate advantages Armenians have had by having gone through a genocide and having spread around the world is that we do have an experience of escaping and of immigrating and of constantly restarting." His family fled Lebanon in 1975, during the civil war there. He graduated from Loyola High School in Montreal in 1978. He received his B.Eng. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA Vaccine
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells. Reactogenicity, the tendency of a vaccine to produce adverse reactions, is similar to that of conventional non-RNA vaccines. People susceptible to an autoimmune response may have an adverse reaction to messenger RNA vaccines. The advantages of mRNA vaccines over traditional vaccines are ease of design, speed and lower cost ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derrick Rossi
Derrick J. Rossi (born 5 February 1966), is a Canadian stem cell biologist and entrepreneur. He is a co-founder of the pharmaceutical company Moderna. Early life and education Rossi was born in Toronto as the youngest of five children of a Maltese immigrant family. His father Fred worked in auto body shops for 50 years and his mother Agnes co-owned a Maltese bakery. Rossi attended the Dr. Norman Bethune High School in Scarborough where he early discovered his passion for molecular biology. He then did his undergraduate and master's degrees in molecular genetics at the University of Toronto. He earned his Ph.D. from the University of Helsinki in 2003 and held a post-doc position from 2003 to 2007 at Stanford University in Irving Weissman’s lab. Career Rossi in 2007 was appointed Associate Professor at the Stem Cell and Regenerative Biology Department at Harvard Medical School and Harvard University. At the same time he was a principal faculty member of the Harvard Stem Cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stéphane Bancel
Stéphane Bancel (born 20 July 1972) is a French business executive. He is the chief executive officer (CEO) of the American pharmaceutical and biotechnology company Moderna, known for its COVID-19 vaccine. Before joining Moderna, Bancel was the CEO of French diagnostics company BioMérieux. Bancel is a partner at Flagship Pioneering, and has served on the boards of Indigo Agriculture, Museum of Science (Boston), Boston's Museum of Science, and Qiagen. As of May 2023, his net worth was estimated at US$4.1 billion, owning about 8% of Moderna. Early life Bancel was born in Marseille, France. His father and mother were an engineer and doctor, respectively. He enjoyed computers, math, and science during his childhood. Bancel studied engineering at CentraleSupélec (former École Centrale Paris) and biological engineering at the University of Minnesota, earning master's degrees at both institutions. He went on to earn an MBA from Harvard Business School. Career Bancel was a sales di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Therapeutics
RNA therapeutics are a new class of medications based on RNA, ribonucleic acid (RNA). Research has been working on clinical use since the 1990s, with significant success in cancer therapy in the early 2010s. In 2020 and 2021, mRNA vaccines have been developed globally for use in combating the coronavirus disease 2019, coronavirus disease (COVID-19 pandemic). The Pfizer–BioNTech COVID-19 vaccine was the first mRNA vaccine approved by a Regulation of therapeutic goods, medicines regulator, followed by the Moderna COVID-19 vaccine, and others. The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), RNA activation (RNAa) and RNA aptamers. Of the four types, mRNA-based therapy is the only type which is based on triggering Protein biosynthesis, synthesis of proteins within cells, making it particularly useful in vaccine development. Antisense RNA is complementary to coding mRNA and is used to trigger mRNA inactivation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and recognize further and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylaxis, prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic vaccines, therapeutic (to fight a disease that has already occurred, such as cancer vaccine, cancer). Some vaccines offer full sterilizing immunity, in which infection is prevented. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Messenger RNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the process of transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and the ribosome creates the protein utilizing amino acids carried by transfer RNA (tRNA). This process is known as translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genetic information in a biological system. As in DNA, genetic inf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cambridge, Massachusetts
Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 United States census, 2020 U.S. census was 118,403, making it the most populous city in the county, the List of municipalities in Massachusetts, fourth-largest in Massachusetts behind Boston, Worcester, Massachusetts, Worcester, and Springfield, Massachusetts, Springfield, and List of cities in New England by population, ninth-most populous in New England. The city was named in honor of the University of Cambridge in Cambridge, England, which was an important center of the Puritans, Puritan theology that was embraced by the town's founders. Harvard University, an Ivy League university founded in Cambridge in 1636, is the oldest institution of higher learning in the United States. The Massachusetts Institute of Technology (MIT), Lesley University, and Hult Inte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chief Executive Officer
A chief executive officer (CEO), also known as a chief executive or managing director, is the top-ranking corporate officer charged with the management of an organization, usually a company or a nonprofit organization. CEOs find roles in various organizations, including public and private corporations, Nonprofit organization, nonprofit organizations, and even some government organizations (notably state-owned enterprises). The governor and CEO of a corporation or company typically reports to the board of directors and is charged with maximizing the value of the business, which may include maximizing the profitability, market share, revenue, or another financial metric. In the nonprofit and government sector, CEOs typically aim at achieving outcomes related to the organization's mission, usually provided by legislation. CEOs are also frequently assigned the role of the main manager of the organization and the highest-ranking officer in the C-suite. Origins The term "chief executi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chairman
The chair, also chairman, chairwoman, or chairperson, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the group or organisation, presides over meetings of the group, and is required to conduct the group's business in an orderly fashion. In some organizations, the chair is also known as '' president'' (or other title). In others, where a board appoints a president (or other title), the two terms are used for distinct positions. The term chairman may be used in a neutral manner, not directly implying the gender of the holder. In meetings or conferences, to "chair" something (chairing) means to lead the event. Terminology Terms for the office and its holder include ''chair'', ''chairman'', ''chairwoman'', ''chairperson'', ''convenor'', ''facilitator'', '' moderator'', ''president'', and ''presiding officer''. The chair of a parliamentary chamb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
