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Lincosamides
Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin. Structure Lincosamides consist of a pyrrolidine ring linked to a pyranose moiety (methylthio-lincosamide) via an amide bond. Hydrolysis of lincosamides, specifically lincomycin, splits the molecule into its building blocks of the sugar and proline moieties. Both of these derivatives can conversely be recombined into the drug itself or a derivative. Synthesis Biosynthesis of lincosamides occurs through a biphasic pathway, in which propylproline and methylthiolincosamide are independently synthesized immediately before condensation of the two precursor molecules. Condensation of the propylproline carboxyl group with the methylthiolincosamide amine group via an amide bond forms ''N''-demethyllincomycin. ''N''-Demethyllincomycin is subsequently Methylation, methylated via S-Adenosyl methionine, ''S''-adenosyl methionine to produce lincomycin A. Lincomycin is naturally produced by bac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clindamycin Mechanism
Clindamycin is a Lincosamides, lincosamide antibiotic medication used for the treatment of a number of bacterial infections, including osteomyelitis (bone) or joint infections, pelvic inflammatory disease, strep throat, pneumonia, acute otitis media (middle ear infections), and endocarditis. It can also be used to treat acne vulgaris, acne, and some cases of methicillin-resistant Staphylococcus aureus, methicillin-resistant ''Staphylococcus aureus'' (MRSA). In combination with quinine, it can be used to treat malaria. It is available by mouth, by intravenously, injection into a vein, and as a cream or a gel to be applied to the skin or in the vagina. Common side effects include nausea and vomiting, diarrhea, skin rashes, and pain at the site of injection. It increases the risk of hospital-acquired Clostridioides difficile infection, ''Clostridioides difficile'' colitis about fourfold and thus is only recommended for use when other antibiotics are not appropriate. It appears t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
