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Cocaine
Cocaine is a tropane alkaloid and central nervous system stimulant derived primarily from the leaves of two coca species native to South America: ''Erythroxylum coca'' and '' E. novogranatense''. Indigenous South Americans have used coca leaves for over a thousand years. Today, cocaine is rarely used medically, primarily as a topical medication, having been replaced due to its high abuse potential, adverse effects, and high cost. Street cocaine is typically snorted, injected, or smoked as crack cocaine, with effects beginning within seconds to minutes and lasting up to 90 minutes depending on the route. Pharmacologically, it is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI). Reinforcing effects include euphoria, improved alertness and concentration, increased libido, a general sense of well-being, and reduced fatigue and appetite. Cocaine has numerous adverse effects. Short-term risks include vasoconstriction, tachycardia, hypertension, hypertherm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tusi (drug)
Tusi (also written as tussi, tuci, or tucibi) is a Recreational drug use, recreational drug that contains a Combination drug, mixture of different Psychoactive drug, psychoactive substances, most commonly found in a pink-dyed powder known as pink cocaine. It is believed to have originated in Latin America, specifically Colombia around 2018. Ketamine and MDMA are the most common ingredients, although cocaine, methamphetamine, oxycodone, caffeine, cathinones, and other designer drugs are found as well. There are no standard proportions of the constituent drugs. The inclusion of pink colorants is an element that seeks to attract consumers, especially young people, by offering a striking visual aspect that resembles something "attractive" or "festive." Though the name "tusi" is phonetically similar to "2C", tusi is not the same psychoactive substance as 2C-B or more broadly, the 2C (psychedelics), 2C family. Tusi, according to the United Nations Office on Drugs and Crime, UN Offic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cocaethylene
Cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver in small amounts when cocaine and ethanol coexist in the blood. In 1885, cocaethylene was first synthesized (according to edition 13 of the ''Merck Index''), and in 1979, cocaethylene's side effects were discovered. Metabolic production from cocaine Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver. Normally, metabolism of cocaine produces two primarily biologically inactive metabolites— benzoylecgonine and ecgonine methyl ester. The hepatic enzyme carboxylesterase is an important part of cocaine's metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin–norepinephrine–dopamine Reuptake Inhibitor
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine. Monoamine structures (including neurotransmitters) contain a singular amino group (mono) linked to an aromatic ring by a chain of two carbons. SNDRIs prevent reuptake of these monoamine neurotransmitters through the simultaneous inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), respectively, increasing their extracellular concentrations and, therefore, resulting in an increase in Serotonin, serotonergic, adrenergic, and dopaminergic neurotransmission. SNDRIs were developed as potential antidepressants and treatments for other disorders, such as obesity, cocaine addiction, attention-deficit hyperactivity disorder (ADHD), and chronic pain. The increase in neurotransmitter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crack Cocaine
Crack cocaine, commonly known simply as crack, and also known as rock, is a free base form of the stimulant cocaine that can be Smoking, smoked. Crack offers a short, intense Euphoria (emotion), high to smokers. The ''Manual of Adolescent Substance Abuse Treatment'' calls it the most Addictive drug, addictive form of cocaine. Crack cocaine first saw widespread use as a recreational drug in primarily Poverty in the United States, impoverished neighborhoods in New York City, Philadelphia, Baltimore, Washington, D.C., Los Angeles, San Francisco and Miami in late 1984 and 1985. This rapid increase in use and availability was named the "Crack epidemic in the United States, crack epidemic", which began to wane in the 1990s. The use of another highly addictive stimulant drug, crystal meth, became popular between 1994 and 2004. Terminology The origin of the name "crack" comes from the "crackling" sound (and hence the onomatopoeic moniker "crack") that is produced when the cocaine and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Injection (medicine)
An injection (often and usually referred to as a "shot" in US English, a "jab" in UK English, or a "jag" in Scottish English and Scots) is the act of administering a liquid, especially a drug, into a person's body using a needle (usually a hypodermic needle) and a syringe. An injection is considered a form of parenteral drug administration; it does not involve absorption in the digestive tract. This allows the medication to be absorbed more rapidly and avoid the first pass effect. There are many types of injection, which are generally named after the body tissue the injection is administered into. This includes common injections such as subcutaneous, intramuscular, and intravenous injections, as well as less common injections such as epidural, intraperitoneal, intraosseous, intracardiac, intraarticular, and intracavernous injections. Injections are among the most common health care procedures, with at least 16 billion administered in developing and transitional ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nasal Administration
Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs, such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, rescue medications for overdose and seizure emergencies, hormone treatments, nicotine nasal spray, and nasal vaccines such as live attenuated influenza vaccine. Risks Nasal septum perforation A nasal septum perforation is a medical condition in which the nasal septum, the bony/cartilaginous wall dividing the nasal cavities, develops a hole or fissure. Nasal administration may cause nasal septum perforation by gradually injuring and ulcerating the epit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topical Medication
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surface area, body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including Cream (pharmaceutical), creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be insufflation (medicine), inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a Human tooth, tooth. The word ''topical'' derives from Ancient Greek, Greek wikt:τοπικός, τοπικός ''topikos'', "of a place". Justification Topical drug delivery is a route of administering drugs via the Human skin, skin to provide topical therapeutic effects. As sk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indigenous Peoples Of South America
In South America, Indigenous peoples comprise the Pre-Columbian peoples and their descendants, as contrasted with people of European ancestry and those of African descent. In Spanish, Indigenous peoples are referred to as (), or (). The term () is used in Argentina, and () is commonly used in Colombia. The English term ''Amerindian'' (short for "Indians of the Americas") is often used in the Guianas. Latin Americans of mixed European and Indigenous descent are usually referred to as (Spanish) and (Portuguese), while those of mixed African and Indigenous ancestry are referred to as . It is believed that the first human populations of South America either arrived from Asia into North America via the Bering Land Bridge and migrated southwards or alternatively from Polynesia across the Pacific. The earliest generally accepted archaeological evidence for human habitation in South America dates to 14,000 years ago, and is located at the Monte Verde site in southern Chile. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Novogranatense
''Erythroxylum novogranatense'' is a neotropical species of ''Erythroxylum'' ( Erythroxylaceae). Cocaine is produced from the leaves. Name "Novogranatense" is derived from Latin: ''novo'' (new) and ''granatense'' (Granada). It was named by William Turner Thiselton-Dyer, the third director of Royal Botanic Gardens, Kew, because its country of origin was the Spanish colonial Viceroyalty of New Granada—present day Colombia. Subspecies ''Erythroxylum novogranatense'' contains 2 subspecies: *''Erythroxylum novogranatense'' var. ''novogranatense'' (D.Morris) Hieron *''Erythroxylum novogranatense'' var. ''truxillense'' (Rusby) Plowman These two subspecies are phenotypically similar, but morphologically distinguishable. Taxonomy Among the genus ''Erythroxylum'', cocaine-rich leaves are obtained from 4 taxa: *'' Erythroxylum coca'' var. ''coca'' *''Erythroxylum coca'' var. '' ipadu'' *''Erythroxylum novogranatense'' var. ''novogranatense'' *''Erythroxylum novogranatense'' var. ''t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Coca
''Erythroxylum coca'' is one of two species of cultivated coca. Description The coca plant resembles a blackthorn bush, and grows to a height of . The branches are straight, and the leaves, which have a green tint, are thin, opaque, oval, and taper at the extremities. A marked characteristic of the leaf is an areolated portion bounded by two longitudinal curved lines, one line on each side of the midrib, and more conspicuous on the underside of the leaf. Coca plants are mainly found in Colombia. The flowers are small, and disposed in little clusters on short stalks; the corolla is composed of five yellowish-white petals, the anthers are heart-shaped, and the pistil consists of three carpels united to form a three-chambered ovary. The flowers mature into red berries. Unlike ''Erythroxylum novogranatense'', ''Erythroxylum coca'' requires very acidic soil conditions. Soil acidity and water acidity need to be below pH 5.5, with the optimal value being pH 3.5, similar to that of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coca
Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. Coca leaves contain cocaine which acts as a mild stimulant when chewed or consumed as tea, with slower absorption than purified cocaine and no evidence of addiction or withdrawal symptoms from natural use. The coca plant is a shrub-like bush with curved branches, oval leaves featuring distinct curved lines, small yellowish-white flowers that develop into red berries. Genomic analysis reveals that coca, a culturally and economically important plant, was domesticated two or three separate times from the wild species ''Erythroxylum gracilipes'' by different South American groups during the Holocene. Chewing coca in South America began at least 8,000 years ago, as evidenced by coca leaves and calcite found in house floors in Peru’s Nanchoc Valley, suggesting early communal use alongside the rise of farming. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, Mood disorder, mood, and physical activity, physical performance. Some stimulants occur naturally, while others are exclusively synthetic. Common stimulants include caffeine, nicotine, amphetamines, cocaine, methylphenidate, and modafinil. Stimulants may be subject to varying forms of regulation, or outright prohibition, depending on jurisdiction. Stimulants increase activity in the sympathetic nervous system, either directly or indirectly. Prototypical stimulants increase synaptic concentrations of neurotransmitter, excitatory neurotransmitters, particularly norepinephrine and dopamine (e.g., methylphenidate). Other stimulants work by binding to the Receptor (biochemistry), receptors of excitatory neurotransmitters (e.g., nicotine) or by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
