Benzothiazoles
Benzothiazole, or more specifically 1,3-benzothiazole, is an aromatic heterocyclic compound with the chemical formula . It is colorless, slightly viscous liquid. Although the parent compound, benzothiazole is not widely used, many of its derivatives are found in commercial products or in nature. Firefly luciferin can be considered a derivative of benzothiazole. It has a sulfurous odor and meaty flavor. The three structural isomer, structural isomers of benzothizaole are 1,3-benzothiazole, 1,2-benzothiazole and 2,1-benzothiazole. Structure and reactivity Benzothiazoles consist of a 5-membered 1,3-thiazole ring Annulation, fused to a benzene ring. The nine atoms of the bicycle and the attached substituents are coplanar. The heterocyclic core of the molecule is readily substituted at the Methine group, methyne (CH) centre in the thiazole ring. Thiazole is electron-withdrawing. Synthesis and biosynthesis Benzothiazoles are typically prepared by treatment of 2-Aminothiophenol, 2-merc ...
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