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Aminopyridines
Aminopyridine may refer to any of several chemical compounds: * 2-Aminopyridine * 3-Aminopyridine * 4-Aminopyridine (4-AP), also known as fampridine or dalfampridine {{Short pages monitor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Aminopyridine
4-Aminopyridine (4-AP) is an organic compound with the chemical formula . It is one of the three isomeric aminopyridines. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials , and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah", according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in the European Union, Canada, and Australia. In Canada, the medication has been approved for use by Health Canada since February 10, 2012. Applications In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. It i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2-Aminopyridine
2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction. Reactions Although 2-hydroxypyridine converts significantly to the pyridone tautomer, the related imine tautomer (HNC5H4NH) is less important for 2-aminopyridine. 2-Aminopyridine catalyzes the conversion of maleic anhydride to 2,3-dimethylmaleic anhydride. Toxicity The acute toxicity is indicated by the LD50 In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. The value of LD50 for a substance is the dose requ ... = 200 mg/kg (rat, oral). References External links MSDS {{DEFAULTSORT:Aminopyridine, 2- 2-Py ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Aminopyridine
3-Aminopyridine is an aminopyridine. It is a colorless solid. Preparation 3-Aminopyridine is prepared by heating nicotinamide with sodium hypobromite ( Hofmann rearrangement), which is in turn prepared ''in situ'' by the reaction of sodium hydroxide and bromine at 70 °C. : It can be used in the synthesis of organic ligand 3-pyridylnicotinamide. Troxipide is another synthesis that uses 3-AP. Toxicity The acute toxicity is indicated by the LD50 In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. The value of LD50 for a substance is the dose requ ... = 178 mg/kg (quail, oral). References {{DEFAULTSORT:Aminopyridine, 3- 3-Aminopyridines 3-Pyridyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
