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Barbital
Barbital (or barbitone), sold under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid; hence, the sodium salt is known also as sodium diethylbarbiturate. Synthesis Barbital, then called "Veronal", was first synthesized in 1902 by German chemists Emil Fischer and Joseph von Mering, who published their discovery in 1903. Barbital was prepared by condensing diethylmalonic ester with urea in the presence of sodium ethoxide, or by adding at least two molar equivalents of ethyl iodide to the silver salt of malonylurea (barbituric acid) or possibly to a basic solution of the acid. The result was an odorless, slightly bitter, white crystalline powder. Its introduction followed the investigations of Fischer and von Mering on the pharmacological properties of ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbiturate
Barbiturates are a class of depressant, depressant drugs that are chemically derived from barbituric acid. They are effective when used medication, medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects. They have been recreational drug use, used recreationally for their anti-anxiety and sedative effects, and are thus prohibition of drugs, controlled in most countries due to the risks associated with such use. Barbiturates have largely been replaced by benzodiazepines and nonbenzodiazepines ("Z-drugs") in routine medical practice, particularly in the treatment of anxiety disorders and insomnia, because of the significantly lower risk of overdose, and the lack of an antidote for barbiturate overdose. Despite this, barbiturates are still in use for various purposes: in general anesthesia, epilepsy, treatment of acute migraines or cluster headaches, acute t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbital Synthese
Barbital (or barbitone), sold under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid; hence, the sodium salt is known also as sodium diethylbarbiturate. Synthesis Barbital, then called "Veronal", was first synthesized in 1902 by German chemists Hermann Emil Fischer, Emil Fischer and Joseph von Mering, who published their discovery in 1903. Barbital was prepared by condensing Diethyl malonate, diethylmalonic ester with urea in the presence of sodium ethoxide, or by adding at least two molar equivalents of ethyl iodide to the silver salt of Barbituric acid, malonylurea (barbituric acid) or possibly to a basic solution of the acid. The result was an odorless, slightly bitter, white crystalline powder. Its introduction followed the investigations of Fischer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayer
Bayer AG (English: , commonly pronounced ; ) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world. Headquartered in Leverkusen, Bayer's areas of business include: pharmaceuticals, consumer healthcare products, agricultural chemicals, seeds and biotechnology products. The company is a component of the EURO STOXX 50 stock market index. Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer (1825–1880) and dyer Friedrich Weskott (1821–1876). The company was established as a dyestuffs producer, but the versatility of aniline chemistry led Bayer to expand its business into other areas. In 1899, Bayer launched the compound acetylsalicylic acid under the trademarked name Aspirin. Aspirin is on the World Health Organization's List of Essential Medicines. In 2021, it was the 34th most commonly prescribed medication in the United State ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypnotic
A hypnotic (from Ancient Greek, Greek ''Hypnos'', sleep), also known as a somnifacient or soporific, and commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to sleep induction, induce sleep and to treat insomnia (sleeplessness). This group of drugs is related to sedatives''. ''Whereas the term sedative describes drugs that serve to calm or Anxiolytic, relieve anxiety, the term hypnotic generally describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness), they are often referred to collectively as sedative–hypnotic drugs. Hypnotic drugs are regularly prescribed for insomnia and other sleep disorders, with over 95% of insomnia patients being prescribed hypnotics in some countries. Many hypnotic drugs are habit-forming and—due to many factors kno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Von Mering
Josef, Baron von Mering (28 February 1849, in Cologne – 5 January 1908, at Halle an der Saale, Germany) was a German physician. Working at the University of Strasbourg, Mering was the first person to discover (in conjunction with Oskar Minkowski) that one of the pancreatic functions is the production of insulin, a hormone which controls blood sugar levels. Mering was curious about the pancreas, a comma shaped organ, situated between the stomach and the small intestine. In an effort to discover its function, he removed the organ from a dog. The dog was then noticed frequently urinating on the floor, although it was house trained. Mering realised that this was a symptom of diabetes and tested the urine, which was found to be high in sugar, confirming his suspicion. Josef von Mering helped to discover barbiturates, a class of sedative drugs used for insomnia, epilepsy, anxiety, and anesthesia. In 1903, he published observations that barbital (then known as diethyl-barbituric ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbituric Acid
Barbituric acid or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active. The compound was first synthesised by Adolf von Baeyer. Naming It remains unclear why Baeyer chose to name the compound that he discovered "barbituric acid". In his textbook ''Organic Chemistry'', the American organic chemist Louis Fieser, Louis Frederick Fieser (1899–1977) initially speculated that the name stemmed from the German word ''Schlüsselbart'' (literally, the beard (''Bart'', Latin: ''barba'') of a key (''Schlüssel''), that is, the bit (key), bit of a key), because Baeyer had regarded barbituric acid as central (or "key") to understanding uric acid and its derivatives. However, Fieser subsequently decided that Baeyer had named the compound after a young lady whom he had met and who was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Propylbarbital
Propylbarbital (Propal, Propanal, Proponal), also known as 5,5-dipropylbarbituric acid, is a barbiturate derivative used as a hypnotic drug A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug i .... References Barbiturates Hypnotics {{sedative-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diethyl-2,2-diethylmalonate
Diethyl diethylmalonate or diethyl 2,2-diethylmalonate is a derivative of diethyl malonate. It can be used in the synthesis of barbital. Uses As being a diethyl malonate derivative, it can be combined with urea under the action of a strong base to form a barbiturate. In this case, diethyl diethylmalonate plus urea forms barbital under the action of sodium ethoxide Sodium ethoxide, also referred to as sodium ethanolate, is the Ionic compound, ionic, organic compound with the formula , , or NaOEt (Et = ethyl group, ethyl). It is a white solid, although impure samples appear yellow or brown. It dissolves in p .... : References Malonate esters Ethyl esters {{ester-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hermann Emil Fischer
Hermann Emil Louis Fischer (; 9 October 1852 – 15 July 1919) was a German chemist and List of Nobel laureates in Chemistry, 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of drawing asymmetric carbon atoms. He also hypothesized lock and key mechanism of enzyme action. He never used his first given name, and was known throughout his life simply as Emil Fischer. Early years and career Fischer was born in Euskirchen, near Cologne, the son of Laurenz Fischer, a businessman, and his wife Julie Poensgen. After graduating he wished to study natural sciences, but his father compelled him to work in the family business until determining that his son was unsuitable. Fischer then attended the University of Bonn in 1871, but switched to the University of Strasbourg in 1872. He earned his doctorate in 1874 under Adolf von Baeyer with his study of phthaleins. Fischer remained with Baeyer i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grain (measure)
A grain is a unit of measurement of mass, and in the troy weight, avoirdupois, and apothecaries' systems, equal to exactly . It is nominally based upon the mass of a single ideal seed of a cereal. From the Bronze Age into the Renaissance, the average masses of wheat and barley grains were part of the legal definitions of units of mass. Expressions such as "thirty-two grains of wheat, taken from the middle of the ear" appear to have been ritualistic formulas. Another source states that it was defined such that 252.458 units would balance of distilled water at an ambient air-water pressure and temperature of and respectively. Another book states that Captain Henry Kater, of the British Standards Commission, arrived at this value experimentally. The grain was the legal foundation of traditional English weight systems, and is the only unit that is equal throughout the troy, avoirdupois, and apothecaries' systems of mass. The unit was based on the weight of a single grain of barl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
