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B Virus
B-virus a virus of the genus '' Simplexvirus'' that infects macaque monkeys. B virus is very similar to Herpes simplex virus 1, and as such, this neurotropic virus is not found in the blood. In the natural host, the virus exhibits pathogenesis similar to that of cold sores in humans. There have been a number of accidental infections and fatalities of researchers working with rhesus monkeys (''Rhesus macaque''). When humans are zoonotically infected with B virus, they can present with a severe encephalitis, resulting in permanent neurological dysfunction or death. Severity of the disease increases for untreated patients, with a case fatality rate of approximately 80%. Early diagnosis and subsequent treatment are crucial to human survival of the infection. Personal protective equipment is necessary when working with macaques, especially with animals that have tested positive for the virus. Bites, scratches, and exposures to mucous membranes, including the eye, have led to infection ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virus
A virus is a submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, more than 16,000 of the millions of List of virus species, virus species have been described in detail. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent viral particles, or ''virions'', consisting of (i) genetic material, i.e., long ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphadenitis
Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency. Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis, producing swollen or enlarged lymph nodes. In clinical practice, the distinction between lymphadenopathy and lymphadenitis is rarely made and the words are usually treated as synonymous. Inflammation of the lymphatic vessels is known as lymphangitis. Infectious lymphadenitis affecting lymph nodes in the neck is often called scrofula. Lymphadenopathy is a common and nonspecific sign. Common causes include infections (from minor causes such as the common cold and post-vaccination swelling to serious ones such as HIV/AIDS), autoimmune diseases, and cancer. Lymphadenopathy is frequently idiopathic and self-limiting. Causes Lymph node enlargement is recognized as a common sign of infectious, autoimmune, or malignant disease. Examples may include: * Reactive: acute infection (e.g., bac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Tegument
A viral tegument or tegument, more commonly known as a viral matrix, is a cluster of proteins that lines the space between the envelope and nucleocapsid of all herpesviruses. The tegument generally contains proteins that aid in viral DNA replication and evasion of the immune response, typically with inhibition of signalling in the immune system and activation of interferons. The tegument is usually released shortly after infection into the cytoplasm. These proteins are usually formed within the late phase of the viral infectious cycle, after viral genes have been replicated. Much information regarding viral teguments has been gathered from studying herpes simplex virus. Properties of teguments Viral teguments can be symmetrically arranged via structural and scaffolding protein or can also be asymmetrically arranged, depending on the virus. Teguments are rarely haphazardly placed and usually involve scaffolding proteins in their formation around the nucleocapsid. Non-essentia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virus Life Cycle
Viruses are only able to replicate themselves by commandeering the reproductive apparatus of cells and making them reproduce the virus's genetic structure and particles instead. How viruses do this depends mainly on the type of nucleic acid DNA or RNA they contain, which is either one or the other but never both. Viruses cannot function or reproduce outside a cell, and are totally dependent on a host cell to survive. Most viruses are species specific, and related viruses typically only infect a narrow range of plants, animals, bacteria, or fungi.N.J. Dimmock et al. ''Introduction to Modern Virology'', 6th edition. Blackwell Publishing, 2007. Life cycle process Viral entry For the virus to reproduce and thereby establish infection, it must enter cells of the host organism and use those cells' materials. To enter the cells, proteins on the surface of the virus interact with proteins of the cell. Attachment, or adsorption, occurs between the viral particle and the host cell membra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hexon Protein
In molecular biology, the hexon protein is a major coat protein found in adenoviruses. Hexon coat proteins are synthesised during late infection and form homo-trimers. The 240 copies of the hexon trimer that are produced are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and penton base (holding in place a fibre), lie at each of the 12 vertices. The hexon coat protein is a duplication consisting of two domains with a similar fold packed together like the nucleoplasmin subunits. Within a hexon trimer, the domains are arranged around a pseudo 6-fold axis. The domains have a beta-sandwich structure A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Icosahedron
In geometry, an icosahedron ( or ) is a polyhedron with 20 faces. The name comes . The plural can be either "icosahedra" () or "icosahedrons". There are infinitely many non- similar shapes of icosahedra, some of them being more symmetrical than others. The best known is the ( convex, non- stellated) regular icosahedron—one of the Platonic solids—whose faces are 20 equilateral triangles. Regular icosahedra There are two objects, one convex and one nonconvex, that can both be called regular icosahedra. Each has 30 edges and 20 equilateral triangle faces with five meeting at each of its twelve vertices. Both have icosahedral symmetry. The term "regular icosahedron" generally refers to the convex variety, while the nonconvex form is called a ''great icosahedron''. Convex regular icosahedron The convex regular icosahedron is usually referred to simply as the ''regular icosahedron'', one of the five regular Platonic solids, and is represented by its Schläfli symbol , contai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herpes Simplex Virus 2
Herpes simplex virus 2 (HHV-2 or HSV-2) is a species of virus in the genus '' Simplexvirus'', subfamily ''Alphaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales''. Evolution Herpes simplex virus 2 can be divided into two clades: one is globally distributed and the other is mostly limited to sub Saharan Africa.Burrel S, Boutolleau D, Ryu D, Agut H, Merkel K, Leendertz FH, Calvignac-Spencer S (2017) Ancient recombination events between human herpes simplex viruses. Mol Biol Evol Pathology Herpes simplex virus 2 infects humans, most often as genital herpes. In the United States more than one in six people have the virus. It is primarily a sexually transmitted infection. Herpes simplex virus 2 tends to reside in the sacral ganglia. Herpes simplex virus 2 is periodically shed in the human genital tract, most often asymptomatically. Most sexual transmissions occur during periods of asymptomatic shedding. Asymptomatic reactivation means that the virus causes at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HSV1
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two members of the human ''Herpesviridae'' family, a set of viruses that produce viral infections in the majority of humans. Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus. As of 2016, about 67% of the world population under the age of 50 had HSV-1. In the United States, about 47.8% and 11.9% are estimated to have HSV-1 and HSV-2, respectively, though actual prevalence may be much higher. Because it can be transmitted through any intimate contact, it is one of the most common sexually transmitted infections. Symptoms Many of those who are infected never develop symptoms. Symptoms, when they occur, may include watery blisters in the skin of any location of the body, or in mucous membranes of the mouth, lips, nose, genitals, or eyes ( herpes simplex keratitis). Lesions heal with a scab characteristic of herpetic disease. Sometimes, the viruses caus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dissection
Dissection (from Latin ' "to cut to pieces"; also called anatomization) is the dismembering of the body of a deceased animal or plant to study its anatomical structure. Autopsy is used in pathology and forensic medicine to determine the cause of death in humans. Less extensive dissection of plants and smaller animals preserved in a formaldehyde solution is typically carried out or demonstrated in biology and natural science classes in middle school and high school, while extensive dissections of cadavers of adults and children, both fresh and preserved are carried out by medical students in medical schools as a part of the teaching in subjects such as anatomy, pathology and forensic medicine. Consequently, dissection is typically conducted in a morgue or in an anatomy lab. Dissection has been used for centuries to explore anatomy. Objections to the use of cadavers have led to the use of alternatives including virtual dissection of computational anatomy, computer models. In the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yerkes National Primate Research Center
The Emory National Primate Research Center (formerly known as Yerkes National Primate Research Center) located in Atlanta, Georgia, owned by Emory University, is a center of biomedical and behavioral research, is dedicated to improving human and animal health, and is the oldest of seven National Primate Research Centers partially funded by the National Institutes of Health. It is known for its nationally and internationally recognized biomedical and behavioral studies with nonhuman primates by Emory University. Its Main Station contains most of the center's biomedical research laboratories. The center also includes the Living Links Center and the Field Station near Lawrenceville, Georgia. History The center was established in 1930 by Robert Yerkes, in Orange Park, Florida, associated then with Yale University. Yerkes was a pioneering primatologist who specialized in comparative psychology. In 1965, it relocated to its location on the campus of Emory University. In April 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herpesvirus Papio
Papiine gammaherpesvirus 1 (PaHV-1), commonly known as baboon lymphocryptovirus, is a species of virus in the genus '' Lymphocryptovirus'', subfamily ''Gammaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales''. This species was the first '' Lymphocryptovirus'' isolated from a non-human primate Primates is an order (biology), order of mammals, which is further divided into the Strepsirrhini, strepsirrhines, which include lemurs, galagos, and Lorisidae, lorisids; and the Haplorhini, haplorhines, which include Tarsiiformes, tarsiers a ... to be described. References External links * Gammaherpesvirinae {{Virus-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Sabin
Albert Bruce Sabin ( ; born Abram Saperstejn; August 26, 1906 – March 3, 1993) was a Polish-American medical researcher, best known for developing the oral polio vaccine, which has played a key role in nearly Poliomyelitis eradication, eradicating the disease. In 1969–72, he served as the president of the Weizmann Institute of Science in Israel. Biography Abram Saperstejn was born in Białystok, Russian Empire (before and since 1918 in Poland), to History of the Jews in Poland, Polish-Jewish parents, Jacob Saperstejn and Tillie Krugman. In 1921, he emigrated with his family on the SS Lapland, SS ''Lapland'' which sailed from Antwerp to the Port of New York and New Jersey, Port of New York. In 1930, he became a naturalized citizen of the United States and changed his name to Albert Bruce Sabin. He graduated from high school in Paterson, New Jersey. Sabin began university in a dentistry program, but was interested in virology and changed majors. He received a bachelor's deg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
