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Riboflavin Synthase
Riboflavin synthase is an enzyme that catalyzes the final reaction of riboflavin biosynthesis. It catalyzes the transfer of a four-carbon unit from one molecule of 6,7-dimethyl-8-ribityllumazine onto another, resulting in the synthesis of riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, 5-amino-6-ribitylamino-2,4(1''H'',3''H'')-pyrimidinedione: :(2) 6,7-dimethyl-8-ribityllumazine → riboflavin + 5-amino-6-ribitylamino-2,4(1''H'',3''H'')-pyrimidinedione Structure The riboflavin synthase monomer has a molecular weight of about 23 kDa. Each monomer contains two beta barrels and one α-helix at the C-terminus (residues 186-206). The monomer folds into pseudo two-fold symmetry, predicted by sequence similarity between the N-terminus barrel (residues 4-86) and the C-terminus barrel (residues 101-184). The interface between these barrels of two different subunits is the location of the active site. The enzyme from different species adopts different quaternary structures, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Riboflavin
Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement. It is essential to the formation of two major coenzymes, flavin mononucleotide and flavin adenine dinucleotide. These coenzymes are involved in energy metabolism, cellular respiration, and antibody production, as well as normal growth and development. The coenzymes are also required for the metabolism of Niacin (nutrient), niacin, vitamin B6, vitamin B6, and folate. Riboflavin is prescription drug, prescribed to treat Corneal ectatic disorders, corneal thinning, and taken orally, may reduce the incidence of migraine headaches in adults. Riboflavin deficiency is rare and is usually accompanied by deficiencies of other vitamins and nutrients. It may be prevented or treated by oral supplements or by injections. As a water-soluble vitamin, any riboflavin consumed in excess of nutritional requirements is not stored; it is either not absorbed or is absorbed and quickly clearance (pharma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pteridines
A pteridine is a bicyclic heterocyclic system with two nitrogen atoms at positions 1 and 4 in ring A, and two nitrogen atoms at positions 1 and 3 in ring B. Pteridines constitute a large group of heterocyclic compounds containing a wide variety of substituents on this parent structure. Pterins and flavins are classes of substituted pteridines that have diverse biological roles. See also * Dihydrobiopterin * Pyrazine * Pyrimidine Pyrimidine (; ) is an aromatic, heterocyclic, organic compound similar to pyridine (). One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring. The oth ... * Tetrahydrobiopterin References {{heterocyclic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
