Foundations of physiology
HumansHuman physiology seeks to understand the mechanisms that work to keep the human body alive and functioning, through scientific enquiry into the nature of mechanical, physical, and biochemical functions of humans, their organs, and the cells of which they are composed. The principal level of focus of physiology is at the level of organs and systems within systems. The endocrine and nervous systems play major roles in the reception and transmission of signals that integrate function in animals. Homeostasis is a major aspect with regard to such interactions within plants as well as animals. The biological basis of the study of physiology, integration refers to the overlap of many functions of the systems of the human body, as well as its accompanied form. It is achieved through communication that occurs in a variety of ways, both electrical and chemical. Changes in physiology can impact the mental functions of individuals. Examples of this would be the effects of certain medications or toxic levels of substances. Change in behavior change (individual), behavior as a result of these substances is often used to assess the health of individuals. Much of the foundation of knowledge in human physiology was provided by Animal testing, animal experimentation. Due to the frequent connection between form and function, physiology and anatomy are intrinsically linked and are studied in tandem as part of a medical curriculum.
PlantsPlant physiology is a subdiscipline of botany concerned with the functioning of plants. Closely related fields include plant morphology, plant ecology, phytochemistry, cell biology, genetics, biophysics, and molecular biology. Fundamental processes of plant physiology include photosynthesis, Respiration in plant, respiration, plant nutrition, tropisms, nastic movements, photoperiodism, photomorphogenesis, circadian rhythms, Germination, seed germination, dormancy, and stomata function and transpiration. Absorption of water by roots, production of food in the leaves, and growth of shoots towards light are examples of plant physiology.
CellsAlthough there are differences between animal, plant, and microbial cells, the basic physiological functions of cells can be divided into the processes of cell division, cell signaling, cell growth, and Metabolism, cell metabolism.
Comparative physiologyInvolving evolutionary physiology and environmental physiology, comparative physiology considers the diversity of functional characteristics across organisms.
The classical eraThe study of human physiology as a medical field originates in classical Greece, at the time of Hippocrates (late 5th century BC). Outside of Western tradition, early forms of physiology or anatomy can be reconstructed as having been present at around the same time in China, India and elsewhere. Hippocrates incorporated his belief system called the theory of humours, which consisted of four basic substance: earth, water, air and fire. Each substance is known for having a corresponding humour: black bile, phlegm, blood and yellow bile, respectively. Hippocrates also noted some emotional connections to the four humours, which Claudius Galenus would later expand on. The critical thinking of Aristotle and his emphasis on the relationship between structure and function marked the beginning of physiology in Ancient Greece. Like Hippocrates, Aristotle took to the humoral theory of disease, which also consisted of four primary qualities in life: hot, cold, wet and dry. Claudius Galenus (c. 130–200 AD), known as Galen of Pergamum, was the first to use experiments to probe the functions of the body. Unlike Hippocrates, Galen argued that humoral imbalances can be located in specific organs, including the entire body. His modification of this theory better equipped doctors to make more precise diagnoses. Galen also played off of Hippocrates idea that emotions were also tied to the humours, and added the notion of temperaments: sanguine corresponds with blood; phlegmatic is tied to phlegm; yellow bile is connected to choleric; and black bile corresponds with melancholy. Galen also saw the human body consisting of three connected systems: the brain and nerves, which are responsible for thoughts and sensations; the heart and arteries, which give life; and the liver and veins, which can be attributed to nutrition and growth. Galen was also the founder of experimental physiology. And for the next 1,400 years, Galenic physiology was a powerful and influential tool in medicine.
Early modern periodJean Fernel (1497–1558), a French physician, introduced the term "physiology". Galen, Ibn al-Nafis, Michael Servetus, Realdo Colombo, Amato Lusitano and William Harvey, are credited as making important discoveries in the circulation of the blood. Santorio Santorio in 1610s was the first to use a device to measure the pulse rate (the ''pulsilogium''), and a thermoscope to measure temperature. In 1791 Luigi Galvani described the role of electricity in nerves of dissected frogs. In 1811, César Julien Jean Legallois studied respiration in animal dissection and lesions and found the center of respiration in the medulla oblongata. In the same year, Charles Bell finished work on what would later become known as the Bell-Magendie law, which compared functional differences between dorsal and ventral roots of the spinal cord. In 1824, François Magendie described the sensory roots and produced the first evidence of the cerebellum's role in Equilibrioception, equilibration to complete the Bell-Magendie law. In the 1820s, the French physiologist Henri Milne-Edwards introduced the notion of physiological division of labor, which allowed to "compare and study living things as if they were machines created by the industry of man." Inspired in the work of Adam Smith, Milne-Edwards wrote that the "body of all living beings, whether animal or plant, resembles a factory ... where the organs, comparable to workers, work incessantly to produce the phenomena that constitute the life of the individual." In more differentiated organisms, the functional labor could be apportioned between different instruments or Biological system, systems (called by him as ''appareils'').R. M. Brain. ''The Pulse of Modernism: Physiological Aesthetics in Fin-de-Siècle Europe''. Seattle: University of Washington Press, 2015. 384 pp.
Late modern periodIn the 20th century, biologists became interested in how organisms other than human beings function, eventually spawning the fields of comparative physiology and ecophysiology. Major figures in these fields include Knut Schmidt-Nielsen and George Bartholomew (biologist), George Bartholomew. Most recently, evolutionary physiology has become a distinct subdiscipline. In 1920, August Krogh won the Nobel Prize for discovering how, in capillaries, blood flow is regulated. In 1954, Andrew Huxley and Hugh Huxley, alongside their research team, discovered the sliding filaments in skeletal muscle, known today as the sliding filament theory. Recently, there have been intense debates about the vitality of physiology as a discipline (Is it dead or alive?). If physiology is perhaps less visible nowadays than during the golden age of the 19th century, it is in large part because the field has given birth to some of the most active domains of today's biological sciences, such as neuroscience, endocrinology, and immunology. Furthermore, physiology is still often seen as an integrative discipline, which can put together into a coherent framework data coming from various different domains.
Women in physiologyInitially, women were largely excluded from official involvement in any physiological society. The American Physiological Society, for example, was founded in 1887 and included only men in its ranks. In 1902, the American Physiological Society elected Ida Hyde as the first female member of the society. Hyde, a representative of the American Association of University Women and a global advocate for gender equality in education, attempted to promote gender equality in every aspect of science and medicine. Soon thereafter, in 1913, J.S. Haldane proposed that women be allowed to formally join The Physiological Society, which had been founded in 1876. On 3 July 1915, six women were officially admitted: Florence Buchanan, Winifred Cullis, Ruth C. Skelton, Sarah C. M. Sowton, Constance Leetham Terry, and Enid M. Tribe. The centenary of the election of women was celebrated in 2015 with the publication of the book "Women Physiologists: Centenary Celebrations And Beyond For The Physiological Society." () Prominent women physiologists include: * Bodil Schmidt-Nielsen, the first woman president of the American Physiological Society in 1975. * Gerty Cori, along with husband Carl Cori, received the Nobel Prize in Physiology or Medicine in 1947 for their discovery of the phosphate-containing form of glucose known as glycogen, as well as its function within Eukaryote, eukaryotic Metabolism, metabolic mechanisms for energy production. Moreover, they discovered the Cori cycle, also known as the Lactic acid cycle, which describes how muscle tissue converts glycogen into lactic acid via lactic acid fermentation. * Barbara McClintock was rewarded the 1983 Nobel Prize in Physiology or Medicine for the discovery of transposition (horizontal gene transfer), genetic transposition. McClintock is the only female recipient who has won an unshared Nobel Prize. * Gertrude Elion, along with George Hitchings and James Black (pharmacologist), Sir James Black, received the Nobel Prize for Physiology or Medicine in 1988 for their development of drugs employed in the treatment of several major diseases, such as leukemia, some autoimmune disorders, gout, malaria, and herpes, viral herpes. * Linda B. Buck, along with Richard Axel, received the Nobel Prize in Physiology or Medicine in 2004 for their discovery of Olfactory receptor, odorant receptors and the complex organization of the olfactory system. * Françoise Barré-Sinoussi, along with Luc Montagnier, received the Nobel Prize in Physiology or Medicine in 2008 for their work on the identification of the Human Immunodeficiency Virus (HIV), the cause of Acquired Immunodeficiency Syndrome (AIDS). * Elizabeth Blackburn, along with Carol W. Greider and Jack W. Szostak, was awarded the 2009 Nobel Prize for Physiology or Medicine for the discovery of the genetic composition and function of telomeres and the enzyme called telomerase.
SubdisciplinesThere are many ways to categorize the subdisciplines of physiology:Moyes, C.D., Schulte, P.M. Principles of Animal Physiology, second edition. Pearson/Benjamin Cummings. Boston, MA, 2008. * based on the taxon, taxa studied: human physiology, animal physiology, plant physiology, microbial physiology, viral physiology * based on the Biological organisation, level of organization: cell physiology, molecular physiology, Biological system, systems physiology, organismal physiology, ecological physiology, integrative physiology * based on the process that causes physiological variation: Developmental biology, developmental physiology, environmental physiology, evolutionary physiology * based on the ultimate goals of the research: applied physiology (e.g., medical physiology), Fundamental science, non-applied (e.g., comparative physiology)
Physiological societiesTransnational physiological societies include: *American Physiological Society *International Union of Physiological Sciences *The Physiological Society National physiological societies include: *Brazilian Society of Physiology
See also* Outline of physiology * Biochemistry * Biophysics * Cytoarchitecture * Defense physiology * Ecophysiology * Exercise physiology * Fish physiology * Insect physiology * Human body * Molecular biology * Metabolome * Neurophysiology * Pathophysiology * Pharmacology * Physiome
BibliographyHuman physiology * * Widmaier, E.P., Raff, H., Strang, K.T. ''Vander's Human Physiology''. 11th Edition, McGraw-Hill, 2009. * Marieb, E.N. Essentials of Human Anatomy and Physiology. 10th Edition, Benjamin Cummings, 2012. Animal physiology * Hill, R.W., Wyse, G.A., Anderson, M. ''Animal Physiology'', 3rd ed. Sinauer Associates, Sunderland, 2012. * Moyes, C.D., Patricia Schulte, Schulte, P.M. ''Principles of Animal Physiology'', second edition. Pearson/Benjamin Cummings. Boston, MA, 2008. * Randall, D., Burggren, W., and French, K. ''Eckert Animal Physiology: Mechanism and Adaptation'', 5th Edition. W.H. Freeman and Company, 2002. * Knut Schmidt-Nielsen, Schmidt-Nielsen, K. ''Animal Physiology: Adaptation and Environment''. Cambridge & New York: Cambridge University Press, 1997. * Withers, P.C. ''Comparative animal physiology''. Saunders College Publishing, New York, 1992. Plant physiology * Larcher, W. ''Physiological plant ecology'' (4th ed.). Springer, 2001. * Salisbury, F.B, Ross, C.W. ''Plant physiology''. Brooks/Cole Pub Co., 1992 * Taiz, L., Zieger, E. ''Plant Physiology'' (5th ed.), Sunderland, Massachusetts: Sinauer, 2010. Fungal physiology * Griffin, D.H. ''Fungal Physiology'', Second Edition. Wiley-Liss, New York, 1994. Protistan physiology * Levandowsky, M. Physiological Adaptations of Protists. In: ''Cell physiology sourcebook: essentials of membrane biophysics''. Amsterdam; Boston: Elsevier/AP, 2012. * Levandowski, M., Hutner, S.H. (eds). ''Biochemistry and physiology of protozoa''. Volumes 1, 2, and 3. Academic Press: New York, NY, 1979; 2nd ed. * Laybourn-Parry J. ''A Functional Biology of Free-Living Protozoa''. Berkeley, California: University of California Press; 1984. Algal physiology * Lobban, C.S., Harrison, P.J. ''Seaweed ecology and physiology''. Cambridge University Press, 1997. * Stewart, W. D. P. (ed.). ''Algal Physiology and Biochemistry''. Blackwell Scientific Publications, Oxford, 1974. Bacterial physiology * El-Sharoud, W. (ed.). ''Bacterial Physiology: A Molecular Approach''. Springer-Verlag, Berlin-Heidelberg, 2008. * Kim, B.H., Gadd, M.G. ''Bacterial Physiology and Metabolism''. Cambridge, 2008. * Moat, A.G., Foster, J.W., Spector, M.P. ''Microbial Physiology'', 4th ed. Wiley-Liss, Inc. New York, NY, 2002.