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Zomebazam produced by
Hoechst Hoechst, Hochst, or Höchst may refer to:
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* Höchst (Frankfurt am Main), a city district of Frankfurt am Main, Germany
** Fra ...
is a pyrazolodiazepinone derivative drug with anxiolytic properties. It is structurally related to razobazam and zometapine.
Synthesis
The catalytic hydrogenation of ''N'',2,5-trimethyl-4-phenyldiazenylpyrazol-3-amine (1) over Raney nickel gives 4-amino-1,3-dimethyl-5-methylaminopyrazole (2). Treatment with methyl malonyl chloride (3) gives 4-α-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole (4). Base-catalyzed lactamization gives (5). TheGoldberg reaction Goldberg or Goldberger may refer to:
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completes the synthesis of zomebazam (6).
See also
*Benzodiazepine
Benzodiazepines (BZD, BDZ, BZs), sometimes called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, ...
References
Notes
{{GABAAR PAMs GABAA receptor positive allosteric modulators Lactams Pyrazolodiazepines