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2MKD, 2MKN

Identifiers Aliases ZNF346, JAZ, Zfp346, zinc finger protein 346 External IDs MGI: 1349417 HomoloGene: 8073 GeneCards: ZNF346
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ZNF346
Genomic location for ZNF346
Band 5q35.2 Start 177,022,696 bp[1]
End 177,081,189 bp[1]
Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012017

RefSeq (protein)

NP_036147

Location (UCSC) Chr 5: 177.02 – 177.08 Mb Chr 13: 55.11 – 55.13 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[5][6]

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113761 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021481 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem. 274 (39): 27399–406. doi:10.1074/jbc.274.39.27399. PMID 10488071. 
  6. ^ a b "Entrez Gene: ZNF346 zinc finger protein 346". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.