ZK-93423 is an

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

drug from the

β-Carboline β-Carboline (9''H''-Pyridine, pyrido ,4-''b''ndole) represents the basic chemical structure for more than one hundred alkaloids and synthetic compounds. The effects of these substances depend on their respective substituent. Natural β-carbo ...

family, closely related to

abecarnil Abecarnil (ZK-112,119) is an anxiolytic drug from the β-Carboline family. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with qu ...

. It is a nonbenzodiazepine GABA_A agonist which is not subtype selective and stimulates α₁, α₂, α₃, and α₅-subunit containing GABA_A receptors equally. It has anticonvulsant,

muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therap ...

and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABA_A receptor.

References

{{DEFAULTSORT:Zk-93423 Anxiolytics Beta-Carbolines Phenol ethers Ethers Carboxylate esters Ethyl esters GABAA receptor positive allosteric modulators

See also

References